Date 09-02-2012
Home page / News    Products    Promotions    News    Contact us    Search Product	Products       Page : Products         Produits / Products :   BIOCHIMIE   Category & Name Product Size Reference Details AIAH Description : An irreversible arginase inhibitor. 25 mg A-1004 AMT.HCl Description : A very potent, selective and reversible inhibitor of inducible Nitric Oxide Synthase (iNOS). IC5O=3.6nm 10 mg A-1002 10z-Hymenialdisine Description : Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cyclin B and CDK2/cyclin E glycogen synthase kinase-b. 500 μg H-1150 1400W Description : A highly selective inhibitor of inducible Nitric Oxide Synthase (iNOS). 5 mg W-1020 4E detection kit Description : Same as eIF-4E, except that, an eIF-4E aliquot is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit E-2018 A-85380.HCl Description : Potent and selective neuronal nicotinic acetylcholine receptor agonist. 1 mg A-1146 A23187 Description : Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. 1 mg A-1130 A23187, Free Acid Description : A widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. 5 mg A-1020 A23187, Mixed Calcium-Magnesium Salt Description : Used in cell activation experiments when calcium dose-response data are not required. Molar ratio Ca:Mg~1:1. 5 mg A-1128 AAG Description : 17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as ''client proteins.'' These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others. 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins. 500 μg A-1256 ABHxD-I.hydrochloride Description : Conformationally restricted ACPD analog. Potent mGluR ligand with similar selectivity and potency to glutamate but without ionotropic activity. Neuroprotective. 500 μg A-1080 Abscisic Acid Description : A plant hormone involved in plant growth and stress response. 500 mg A-1094 Abscisic Acid Description : Natural isomer of the abscission accelerating plant hormone. 1 g A-1103 Abscisic Acid Product name : Abscisic Acid A-1124 ACRP30 (Human) (HADI 741) Description : Western blot analysis of recombinant globular domain of ACRP30 with AX741 MAb at a 1:5'000 dilution. Clone: AX741. Immunogen: Recombinant human ACRP30 expressed in mammalian cells. Isotype: Mouse IgG1. 50 μg A-1278 ACRP30 (Human) (HADI 773) Description : Immunogen: Recombinant human ACRP30. Clone: AX 773. Isotype: Mouse IgG1. Western blot analysis of human plasma ACRP30 with AX773 MAb at a concentration of 0.2µg/ml. 50 μg A-1276 ACRP30 (Human) (Ne.Na) Description : Immunogen: Recombinant human ACRP30headless. Specificity: Recognizes human ACRP30. Clone: Ne.Na. Does not cross-react with mouse ACRP30. Isotype: Mouse IgG1. Figure: MAb to ACRP30 (Ne.Na) detects human ACRP30headless by Western blot. 100 μg A-1280 ACRP30 (Mouse) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 18-32 and 187-200 of mouse adipocyte complement related protein of 30 kDa (ACRP30). Specificity: Recognizes mouse ACRP30. Application: Immunoprecipitation, Western blot. 200 &#956;g A-1284 ACRP30 (Mouse) (MADI 1147) Description : Immunogen: Recombinant mouse ACRP30 expressed in mammalian cells. Clone: AX1147. Isotype: Mouse IgG1. Western blot analysis of ACRP30 in human, mouse and rat plasma with AX1147 at 1:5'000 dilution. 50 μg A-1282 ACRP30, Soluble (Mouse) (Recombinant) Description : Source: Produced in HEK 293. Mouse ACRP30 (aa 18-247) fused at the N-terminus to a linker peptide (8 aa) and a FLAG tag. Reconstitution: Reconstitute with 50µl sterile water. Application: Inhibits serum glucose production in mice. *M.W.: SDS-PAGE under reducing conditions. 50 μg A-1274 ACRP30headless (Human) Description : Source: Produced in HEK 293 cells. The non-homologous (aa16-45) and collagen domain of human ACRP30 (aa 45-108) are fused at the N-terminus to a FLAG-epitope tag. Reconstitution: Reconstitute with 100µl sterile water. *M.W.: SDS-PAGE under reducing conditions. 10 μg A-1272 ACRP30headless (Human) Control Compound Description : See product # A1272 A-1238 Actinomycin D Description : Inhibitor of nucleic acid synthesis. Also a potent inducer of apoptosis. 5 mg A-1022 Actinomycin D Description : Fluorescent DNA Stain. Binds Single stranded DNA. Useful tool in determining apoptosis. 1 mg A-1132 Actinonin Description : Antibiotic that demonstrates anti-tumor activity. Also unique antibacterial agent. Inhibitor of leucine aminopeptidase. 5mg A-1120 Actinopyrone A Description : Recently purified metabolite, Potential anti-Helicobacter pylori . Please inquire. A-1290 Actinopyrone B Description : Recently purified metabolite, Potential anti-Helicobacter pylori . Please inquire. A-1291 Actinopyrone C Description : Recently purified metabolite, Potential anti-Helicobacter pylori . Please inquire. A-1291C Adenophostin A Description : A potent Inositol-1,4,5-trisphosphate (IP3) receptor agonist. 10 times more potent than IP3. 50 μg A-1126 AEBSF.hydrochloride Description : Specific irreversible inhibitor of serine proteases, such as thrombin, plasmin, kallikrein, chymotrypsin, and trypsin. It is a non- toxic alternative to PMSF. AEBSF is affected by both pH and temperature. AEBSF undergoes hydrolysis at ph >7 and this rate is increased at higher temperatures. It is recommended to make solutions fresh before use. 50 mg A-1018 AF DA Description : Negative control compound for the fluorescent probes DAF-2 and DAF-2 DA. 1 mg A-1140 Aflatoxin EIA Description : Crossreactivity: By the assay, the following compounds tested at the stated levels are found to give results not greater than a level of 0.5 1 Kit A-1234 AG 1007 Product name : AG 1007 1 mg A-1180 AG 1024 Description : An inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. 1 mg A-1178 AG 1112 Product name : AG 1112 1 mg A-1176 AG 126 Product name : AG 126 5 mg A-1208 AG 1288 Product name : AG 1288 5 mg A-1192 AG 1295 Product name : AG 1295 5 mg A-1188 AG 1296 Product name : AG 1296 5 mg A-1174 AG 1385 Product name : AG 1385 1 mg A-1170 AG 1433 Description : Potent and specific inhibitor of PDGF-b receptor kinase (IC50 = 5.0 μm) and Flk-1/KDR (IC50 = 9.3 μm). Also acts as an angiogenesis inhibitor. 5 mg A-1168 AG 1478 Product name : AG 1478 1 mg A-1296 AG 1498 Product name : AG 1498 5 mg A-1172 AG 183 Product name : AG 183 5 mg A-1206 AG 34 Product name : AG 34 1 mg A-1212 AG 370 Description : Inhibitor of platelet derived growth factor (PDGF) autophosphorylation and PDGF-induced mitogenesis. 1 mg A-1186 AG 490 Description : Inhibitor of epidermal growth factor receptor kinase. Inhibits JAK2, and CDK2 activation. 5 mg A-1164 AG 494 Description : Inhibitor of epidermal growth factor receptor kinase. Inhibits CDK2 activation and causes cell cycle arrest at late G1 and S phase. 5 mg A-1166 AG 527 Product name : AG 527 25 mg A-1214 AG 528 Product name : AG 528 5 mg A-1204 AG 537 Description : Competitively inhibits EGF receptor kinase autophosphorylation. 5 mg A-1202 AG 658 Product name : AG 658 1 mg A-1200 AG 698 Product name : AG 698 25 mg A-1218 AG 808 Product name : AG 808 5 mg A-1184 AG 82 Product name : AG 82 25 mg A-1210 AG 825 Description : Selective inhibitor of HER2 compared to HER1. 1 mg A-1182 AG 835 Product name : AG 835 25 mg A-1216 AG 879 Product name : AG 879 1 mg A-1198 AG 957 Product name : AG 957 5 mg A-1196 AG 974 Product name : AG 974 5 mg A-1194 Agrochelin Description : A new alkaloid cytotoxic substance produced by the fermentation of Agrobacterium sp. 10 mg A-1260 AIAP Description : An irreversible arginase inhibitor. 25 mg A-1006 AIDA, UPF-523 Description : A potent and selective ligand for mGluR1 metabotropic receptor subtypes. 5 mg A-1012 AK Description : Affinity-purified antibody to AK. Raised in rabbits to a synthetic peptide corresponding to residues 273-291 of the human kidney protein. 100 μl A-1228 AK assay kit Description : Useful for determining the activity of AK or related protein serine kinase. Can be use to evaluate the effect of a test substance on AK activity or to identify new physiological substrates of the enzyme. Kit includes directional insert, and contains solutions of MgATP, MBP, assay buffer, and purified AK sample. 1 Kit A-1224 AK detection kit Description : Same as Anti-AK, except that, an aliquot of an AK preparation is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit A-1226 AK detection kit Description : Same as Anti-AK, except that, an AK aliquot is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit A-1230 Alamethicin Description : Membrane permeabilizing Antibiotic. Increases [32P] incorporation into phosphatidylinositol-4-phosphate. 5 mg A-1286 Albofungin Description : Recently purified metabolite, please inquire A-1292 Alsterpaullone Description : Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK1/cyclin B (IC50=0.035uM). High in vitro anti-tumor potency. 1 mg A-1136 AMC Description : Reagent used to prepare fluorogenic AMC based substrates for the detection of proteolytic enzymes. Also useful as a reference standard in enzyme assays. 10 mg A-1148 Amino-3-(5-chloro-2-thienyl)-butanoic acid Description : Potent and selective GABAB agonist. 10 mg A-1028 Aminobenzotriazole Description : A suicide inhibitor of cytochrome P-450 and chloroperoxidase. 1 g A-1010 Aminocyclopentane - cis - 1,3 - Dicarboxylic acid Description : Potent NMDA agonist. 10 mg A-1030 Aminocyclopentane - trans - 1,3 - Dicarboxylic acid Description : Agonist at quisqualate metabotropic receptors GluR1 and GluR5, as well as GluR2 and GluR3 receptors, but not at receptors sensitive to AP4. 1 mg A-1032 Aminogenistein Description : Inhibits the Protein-Tyrosine Kinase Activity of p56lck. 1 mg A-1106 Aminopterin Description : Folic acid antagonist. Potent dihydrofolate reductase inhibitor. 10 mg A-1294 AMPA Description : Potent and selective quisqualate analog that interacts with neuronal glutamate receptors. 25 mg A-1034 AMPA Description : Active enantiomer of AMPA. 5 mg A-1036 AMPA Description : Inactive enantiomer of AMPA. 5 mg A-1047 Amphotericin B, Streptomyces nodosus Description : Anti-fungal agent used for prevention or elimination of fungal contaminants in cell cultures. Also used as an inhibitor of yeasts, molds and mycoplasma in cell cultures. 1 g A-1077 Ampullosporin A Description : Induces pigment formation by the fungus Phoma destructiva, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes. 1 mg A-1266 Anatoxin A.Fumerate Description : Nicotinic Receptor Agonist. 1mg A-1065 Angiostatin, Human, Bioactive Description : A proteolytic fragment of plasminogen constituting kringles 1-4, which is a specific inhibitor of endothelial cell proliferation and one of the most potent and specific natural inhibitors of angiogenesis and metastatic tumor growth. 500 μg A-1156 Anisomycin, Streptomyces griseolus Description : Anti-fungal antibiotic which inhibits Protein Synthesis. Also activates p54, MAP Kinases and Stress-Activated Protein Kinases. Used in Martin-Lewis Medium to inhibit C. albicans and aid in identification of N. gonorrhoeae. Antiprotozoal agent. 50 mg A-1049 Annexin V Description : Specificity: Specifically recognizes human annexin V (VAC-α. Clone: VAA-33, Isotype: Mouse IgG2a. Application: ELISA, FC. 100 μg M-1070 Annexin V (APC Labelled), Human, Recombinant Description : Used to detect apoptotic cells. It has a strong affinity for phosphatidylserine which is translocated to the outer layer of the cell membrane during the early phases of apoptosis. 20 Tests A-1086 Annexin V (Biotin Labelled), Human, Recombinant Description : Used to detect apoptotic cells. It has a strong affinity for phosphatidylserine which is translocated to the outer layer of the cell membrane during the early phases of apoptosis. Concentration: 300 tests: 300 μg in 1.5 ml; 20 tests: 20 μg in 100 ul. Formulation: Contains 50 mM TRIS, 100 mM Sodium Chloride, 1% BSA, and 0.02% Sodium Azide, pH 7.4. 20 Tests A-1090 Annexin V (FITC Labelled), Human, Recombinant Description : Used to detect apoptotic cells. It has a strong affinity for phosphatidylserine which is translocated to the outer layer of the cell membrane during the early phases of apoptosis. Concentration: 300 tests: 300 μg/1.5 m. Formulation: containing 50 mM TRIS, 100 mM Sodium Chloride, 1 % BSA and 0.2% Sodium Azide, pH 7.4. 20 Tests A-1092 Annexin V (FITC) Description : Recombinant human Annexin V (FITC), expressed in bacteria, purified. *M.W.: Under reducing conditions. 100 tests A-1244 Annexin V, Human, Recombinant Description : Used to detect apoptotic cells. It has a strong affinity for phosphatidylserine which is translocated to the outer layer of the cell membrane during the early phases of apoptosis. 30 μg A-1088 Antimycin A Description : Induces apoptosis, which is not prevented by the presence of bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1. A-1268 AP3 Product name : AP3 5 mg A-1044 AP3 Description : NMDA receptor antagonist. 250 mg A-1045 AP4 Description : Broad spectrum excitatory amino acid receptor antagonist. 10 mg A-1038 AP4 Description : NMDA receptor antagonist. 100 mg A-1040 AP4 Description : Agonist at mGluR4 and mGluR6 glutamate receptors. 1 mg A-1042 AP5 Description : Potent and selective antagonist for NMDA receptors. Active enantiomer. 10 mg A-1059 AP5 Description : Potent NMDA receptor antagonist. 10 mg A-1061 AP7 Description : Anticonvulsant. More active form of AP7. 5 mg A-1050 AP7 Description : Potent NMDA receptor antagonist. Anticonvulsant. 10 mg A-1051 AP7 Description : Less active form of AP7. 10 mg A-1053 Aphidicolin, Nigrospora oryzae Description : Reversible inhibitor of eukaryotic nuclear DNA replication. 1 mg A-1026 Apicidin Description : Potent inhibitor of histone deacetylase (HDAC) (IC50=700pM). 1 mg A-1264 Apigenin Description : A MAP Kinase inhibitor. 10 mg A-1108 APO-1/Fas (Human) Description : Specificity: Specifically recognizes human Fas. Clone: SM1/23. Blocks induction of apoptosis induced by clone SM1/1 100 μg F-1032 APRIL Description : rhsMegaAPRIL induces Swiss NIH-3T3 cells to proliferate in low serum conditions. Concentration:0.1mg/ml after reconstitution. Application: Can be used to sustain proliferation of serum-starved NIH-3T3 cells. *M.W.: For the chimeric protein (SDS-PAGE, under reducing conditions. 3x10 ug A-1236 Arachidonic Acid Description : Acts as a second terms potentiation in the nervous system. Product inhibits Ras-GAP. A-1302 ARL-67156 Description : An ecto-ATPase inhibitor. 10 mg A-1067 Arvanil Description : Activator of cannabinoid and vanilloid receptors. Demonstrates anti-proliferative activity in breast cancer. 5 mg A-1138 Ascomycin, Streptomyces hygroscopicus var ascomyceticus Description : An ethyl analog of FK506 with strong immunosuppressant properties. Acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. 1 mg A-1258 Astaxanthin Description : Extremely potent antioxidant 1 g A-1144 ATPA Description : Inactive enantiomer of ATPA at the GluR5 kainate receptor agonist. 5 mg A-1070 ATPA Description : Active enantiomer of ATPA. Potent and selective agonist at the GluR5 kainate receptor. 5 mg A-1072 Aurantimycin A Description : Strong antibiotic activity against gm-positive bacteria and cytotoxicity. Shows inhibitory effects on cellular adhesion and anaphylatoxin receptor binding. 1 mg A-1270 Azidothymidine (AZT) EIA Description : The enzyme immunoassay for AZT is based on the competition between the AZT to be assayed and the AZT-horseradish peroxidase conjugate, for binding to antibody directed against AZT, coated onto microtiter wells. The bound enzymatic activity is then measured by the addition of a chromogenic substrate. The intensity of the color developed is inversely proportional to the concentration of AZT in the sample. The sample containing the AZT, and the AZT-horseradish peroxidase conjugate, when added to the microtiter wells, compete for binding to a limiting number of antibody sites. After incubation, each well is rinsed in order to remove non-bound components. 1 Kit A-1232 BACE1 Description : Source: Rabbits were immunized with a synthetic peptide sequence based on amino acids 485-501 of human BACE protein. Cross-Reactivity: Hu, Ms. Application: WB (1/500 – 1/1,000). Two proteases, β- and γ-secretase, are responsible for the endoproteolysis of amyloid precursor protein (APP) to form Aβ peptide. There are two homologs of BACE (β-site APP Cleaving Enzyme), BACE1 (Asp2; Memapsin2) and BACE2 (Asp1). Accumulation of Aβ peptide creates amyloid plaques which progressively develop in the brains of patients with Alzheimer’s Disease (AD). 0.2 ml B-1253 BACE2 Description : Source: Rabbits were immunized with a synthetic peptide sequence based on amino acids 44-59 of human BACE2 protein. Cross-Reactivity: Hu, Ms, Rt. Application: WB (1/500 – 1/1,000). Two proteases, β- and γ-secretase, are responsible for the endoproteolysis of APP to form Aβ peptide. There are two homologs of BACE (β-site APP Cleaving Enzyme), BACE1 (Asp2; Memapsin2) and BACE2 (Asp1). Accumulation of Aβ peptide creates amyloid plaques which progressively develop in the brains of patients with Alzheimer’s Disease (AD). 0.2 ml B-1255 BACE2 Description : Source: Rabbits were immunized with a synthetic peptide sequence based on amino acids 496-511 of human BACE2 protein. Cross-Reactivity: Human. Application: WB (1/500 – 1/1,000). Two proteases, β- and γ-secretase, are responsible for the endoproteolysis of APP to form Aβ peptide. There are two homologs of BACE (β-site APP Cleaving Enzyme), BACE1 (Asp2; Memapsin2) and BACE2 (Asp1). Accumulation of Aβ peptide creates amyloid plaques which progressively develop in the brains of patients with Alzheimer’s Disease (AD). 0.2 ml B-1257 Bacitracin Description : Antibiotic that demonstrates antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. B-1261 Baclofen (USP grade) Description : A GABAB (biculline insensitive) agonist. Muscle relaxant. 1 g B-1013 Baclofen.Hydrochloride Description : Selective agonist for the GABAB receptor. More active enantiomer of (±)-Baclofen. 10 mg B-1011 Bafilomycin A1 from Streptomyces griseus Description : A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. 100 μg B-1183 Bafilomycin B1 from Streptomyces griseus Description : A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. 1 mg B-1185 Bafilomycin B2 from Streptomyces griseus Product name : Bafilomycin B2 from Streptomyces griseus B-1245 Bapta(AM) Product name : Bapta(AM) 25 mg B-1083 Bapta(AM) Product name : Bapta(AM) 25 mg B-1085 Bapta(K+ Salt) Product name : Bapta(K+ Salt) 1 g B-1087 Bapta(K+ Salt) Product name : Bapta(K+ Salt) 100 mg B-1089 Bapta-FF (AM) Product name : Bapta-FF (AM) 10 mg B-1093 Bapta-FF (free acid) Product name : Bapta-FF (free acid) 10 mg B-1091 Batumin Description : Antibiotic with high and selective activity against Staphylococcus strains including methicillin-resistant S. Aureus (MRSA) strains in a concentration of 1-10ng/ml. 10 mg B-1249 Bax (2D2), Human Description : Immunogen: Synthetic peptide corresponding to aa 3-16 of human Bax. Specificity: Recognizes human Bax. Isotype: Mouse IgG1. Application: ELISA, ICC, IP, WB. 100 μg B-1213 Bax (6A7), Universal Description : Immunogen: Synthetic peptide corresponding to aa 12-24 of human Bax. Specificity: Recognizes human, mouse, and rat Bax. Binds to the monomeric form of Bax and not to Bax complexed with either Bcl-2 or Bcl-X. Isotype: Mouse IgG1. Application: ELISA, ICC, IP,WB. 100 μg B-1211 BAY-K-8644 Description : A Ca2+ slow channel agonist. 5 mg B-1019 BCECF (AM) Description : Widely used fluorescent indicator of intracellular pH. It has a pKa of 7.0, which is perfectly matched to the normal range of cytoplasmic pH. It's fluorescence excitation profile is also pH dependent. 1 mg B-1097 BCECF (free acid) Product name : BCECF (free acid) 1 mg B-1095 Bcl 10 (Carmen-1) Description : Immunogen: Recombinant human Bcl 10. Specificity: Recognizes human and mouse Bcl10. Clone: Carmen-1, Isotype: Rat IgM. Application: WB. 100 μg B-1203 Bcl-2 (Human) (8C8) Description : Immunogen: Synthetic peptide corresponding to aa 41-54 of human Bcl-2. Specificity: Recognizes human Bcl-2. Isotype: Mouse IgG1. Application: WB. 100 μg B-1215 Bcl-2 (Human) (Bcl-2/100) Description : Immunogen: synthetic peptide corresponding to aa 41-54 of human Bcl-2. Specificity: Recognizes human Bcl-2. Isotype: Mouse IgG1. Application: FC, IHC (FS, PS) IP, WB FITC 120 tests B-1217 Bcl-2 (Purified) Description : Source: Rabbit. Immunogen: synthetic peptide corresponding to aa 20-34 of human Bcl-2. Specificity: Recognizes human, mouse Bcl-2. This antibody is particularly useful for the detemination of the level of expression of Bcl-2 in species other than human. Application: IHC (FS, PS), WB. 100 μg B-1219 Bcl-w (13F9) Description : Immunogen: Human recombinant Bcl-w. Specificity:Recognizes human, mouse, rat, monkey and dog Bcl-w. Isotype: Rat lgG2a. Application: IP, (WB). 100 μg B-1221 Bcl-w (16H12) Description : Immunogen: Human recombinant Bcl-2. Specificity: Recognizes human, mouse, rat, monkey and dog Bcl-w. Isotype: Rat IgG2a. Application: (IP), WB. 100 μg B-1223 Bcl-X L/S (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 201-216 of human Bcl-X. Specificity: Recognizes human, mouse, rat Bcl-XL (strongly) and Bcl-XS (moderately). Application: IHC (FS, PS), WB. 100 μg B-1225 Benzyl-APDC.HCL Description : mGluR6-selective ligand. 1 mg B-1067 Benzylquisqualic Acid Description : Selective antagonist of group II mGluRs. 1 mg B-1073 Berberine.sulfate.3H20 Description : The alkaloid berberine exhibits relatively weak antibiotic properties (1), apparently because of its efflux by multidrug resistance pumps (s). Recently it was described that the antimicrobial action of berberine is potentiated by 5'-methoxyhydnocarpin … 1g B-1201 Bestatin.HCl Description : Aminopeptidase inhibitor. 5 mg B-1075 Betulinic acid Description : Anti-tumor, anti-HIV agent which induces apoptosis via activation of caspases. 20 mg B-1191 Bid (Human) (Rec.) Description : Produced in E. coli. Affinity purified full length human Bid (aa-1-195).Useful for studies of Bid/Bax interaction and in vitro cytochrome c release. Specificity: Facilitates Bax oligomerization and induces cytochrome c release when cleaved by caspase-8 to generate truncate truncated protein (+-Bid) is isolated mitochondria. 20 μg B-1207 Bid (truncated) (Human) (Rec.) Description : Produced in E.coli. Affinity purified C-terminal part of human Bid (aa 61-195). Specificity: Facilitates Bax oligomerization and induces cytochrome c release in isolated mitochondria. Useful for studies of Bid/Bax interaction and in vitro cytochrome c release. 20 μg B-1209 BIF-1 [Bax interacting factor-1] (Human) (30A882) Description : Immunogen: Full length human recombinant BIF-1. Specificity: Recognizes human BIF-1. Isotype: mouse IgG. Application: WB. 100 μg B-1229 Bim (Purified) Description : Source: Rabbit. Immunogen: synthetic peptide corresponding to aa 22-40 of human Bim. This sequence is identical to that of mouse and differs from that of rat by one amino acid. Specificity: Recognizes human, mouse and rat Bim. Application: WB Blocking Peptid. 100 μg B-1237 BIM S/EL/L (14A8) Description : Immunogen: Recombinant mouse BimS. Specificity: Recognizes human, monkey and mouse BimL, BimEL and BimS. Isotype: Rat IgG2a. Application: FC, ICC, IHC (PS), IP, WB. 100 μg B-1239 BimL (5E5) Description : Immunogen: Recombinant mouse BimL. Specificity: Recognizes human, monkey and mouse BinL. Isotype: Rat IgG2b. Application: FC, ICC, IHC (PS), IP, WB. 100 μg B-1241 Binaltorphimine.Dihydrochloride Description : κ-opioid receptor antagonist. 1 mg B-1027 Bistheonellide A Description : Isolated from the marine sponge Theonella sp. Inhibits actin polymerization by forming a 1:2 complex with G-actin. 100 μg B-1195 Blankophor, Phorwhite BBU Description : A highly selective fluorescent probe of β-amyloid and amyloid plaque core protein (APCP). Does not fade during prolonged exposure to UV-blue exciting light. 25 ml B-1003 Blasticidin S . HCl Description : Inhibitor of DNA and protein synthesis. Blasticidin S is a peptidyl nuncleoside antibiotic isolated from the culture broth of Stretomyces girseochromogenes. Blasticidin S is used to select transfected cells carrying bsr or BSD resistance genes. 1 x 100 mg vial provided as a dry solid. 5 x 2 ml vials provided at a concentration of 10 mg / ml in Hepes buffer (100 mg total). 100 mg B-1247 Blocking Peptide to Antiserum (Purified) to FLIP (NT) Description : Synthetic peptide corresponding to aa 2-18 of human FLIP. 50 μg F-1122 Blocking Peptide to Antiserum (Purified) to TRAIL-R2 Description : Synthetic peptide corresponding to aa 68-94 of the extracellular domain of human TRAIL-R2. 100 μg T-1102 Blocking Peptide to Antiserum (Purified) to TRAIL-R2 (CT) Description : Synthetic peptide corresponding to aa 388-407 of human TRAIL-R2 precursor. 50 μg T-1100 Blocking Peptide to Antiserum (Purified) to TRAIL-R3 (Human) Description : Synthetic peptide corresponding to aa 33-63 of the exptracllular domain of human TRAIL-R3. 100 μg T-1112 BMF (12E10) Description : Immunogen: Mouse recombinant BMF. Specificity: Recognizes human and mouse BMF. Isotype: Rat IgG1. Application: FC, IP, WB. 100 μg B-1231 BMF (9G10) Description : Immunogen: Mouse recombinant Bmf. Specificity: Recognizes human and mouse Bmf. Isotype: Rat IgG2a. Application: FC, IP,WB. 100 μg B-1233 BMF (Purified) Description : Source: Rabbit. Immunogen: Mouse recombinant Bmf. Specificity: Recognizes human, mouse and rat Bmf. Application: FC, ICC (excellent), WB. 100 μl B-1235 Bongkrekic Acid Description : An inhibitor of the mitochondrial permeability transition. It acts as an inhibitory ligand of the mitochondrial adenine nucleotide translocator. Also inhibits apoptosis by preventing PARP cleavage and DEVDase activity. 100 μg B-1053 BOP Reagent Product name : BOP Reagent 500 g B-1187 Borrelidin Description : Nanomolar Angiogenesis Inhibitor. Potent angiogenesis inhibitor that induces apoptosis of the capillary tube-forming cells. Also displays antimalarial activity against drug-resistent Plasmodia. Please inquire. B-1260 BQ-123.Sodium Salt Description : A highly potent and selective ETA-receptor antagonist. 1 mg E-1032 BQ-788.Sodium Salt Description : A highly potent and selective ETB-receptor antagonist. 500 μg E-1034 Breast Cancer Resistance Protein (BCRP; MXR) (Human) (BXP-34) Description : Specificity: Recognizes internal epitope of human BCRP (MXR). Clone: BXP-34. Isotype: Mouse IgG1. Application: ICC (cytospin preparation), IHC (FS only, PS not recommended). 125 μg B-1199 Breast Cancer Resistance Protein (BCRP;MXR) (Human) (BXP-21) Description : Immunogen: purified breast cancer resistance protein (BCRP:MXR) peptide (aa 271-396). Specificity: Recognizes internal epitope of human BCRP (MXR). Clone: BXP-21. Isotype: Mouse IgG2a. Application: ICC (cytosping preparations), IHC (FS, PS), WB. 125 μg B-1197 Brefeldin A, Eupenicillium brefeldianum Description : Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. 10 mg B-1009 Bromo-7-Nitroindazole Description : A potent inhibitor of rat cerebellar Nitric Oxide Synthase (NOS). More potent inhibitor than 7-nitroindazole 25 mg B-1001 Bromo-homo-ibotenic Acid Description : Inhibitor of CaCl2-stimulated [³H]-glutamate binding. Inactive at AMPA and metabotropic glutamate receptors. 10 mg B-1023 Bromo-homo-ibotenic Acid Description : Active isomer at AMPA receptors. Acts as an agonist at native group 1 metabotropic glutamate receptors, but as an antagonist at cloned mGlu1a receptors. 10 mg B-1025 Bromocriptine mesylate Description : Dopamine agonist. 100 mg B-1193 Bromoenol.Lactone Description : An inhibitor of Ca2+-independent PLA2. 5 mg B-1077 Buthionine-(S,R)-Sulfoximine Description : Glutathione synthesis inhibitor 1 gm B-1079 Buthionine-(S,R)-Sulfoximine Description : Glutathione (GSH)-depleting agent. 1gm B-1081 c-Cbl (5C4) Description : Immunogen: Synthetic peptide corresponding to aa 695-705 of human c-Cbl. Specificity: Recognizes human and mouse c-Cbl.Clone: 5C4. Isotype: Mouse IgG1. c-Cbl (an Insulin Receptor Substrate) is a proto-oncogene known to interact with the insulin receptor.This antibody recognizes human and mouse c-Cbl and is used in ELISA & Western Blot applications. 100 μg C-1377 C75 Description : Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. C75 exhibits irreversible slow-binding biphasic inactivation of fatty acid sythase. 1 mg C-1373 CA 1001 Description : Neutral with very high selectivity for Ca2 ions. Determines Ca2 activity in membrane electrodes, also for transport studies in biological membranes. 25 mg E-2026 Calcein-AM Description : Cell permeable derivative of calcein. Calcein-AM has been used in a functional assay to measure Pgp and MRP activities in acute myeloid leukemia patients 1 mg C-1265 Calcitriol Description : Biologically active form of Vitamin D3 in intestinal calcium transport and bone calcium reabsorption. Stimulates Osteoprotegerin. 100 ug C-1026 Calpain Inhibitor I Description : Inhibitor of calpain I, calpain II, cathepsin B and cathepsin L. Inhibits neutral cysteine proteases and the proteasome. 10 mg P-1153 Calpain Inhibitor II Description : Inhibitor of calpain I, calpain II, cathepsin B and cathepsin L. Inhibits activation-induced programmed cell death. Also inhibits the peptidase activity of the 20S proteasome. 10 mg C-1259 Calyculin A, Discodermia calyx Description : Marine toxin which inhibits protein phosphatase 2A and protein phosphatase 1. Also potent tumor promoter. 50 μg C-1031 Camptothecin Description : Inhibitor of nuclear topoisomerase I by binding to and trapping the topoisomerase-DNA covalent complex. 250 mg C-1261 Cantharidin Description : Acts as a potent and selective inhibitor of protein phosphatase 2A. Also inhibits protein phosphatase 1 at higher concentrations. Useful in inhibition of PP1 and PP2A during purification of phosphorylated porteins. 10 mg C-1412 CAPS Description : Biological buffer with a useful pH range of 10.0-11.4. pKa=10.4 at 25°C. 1 kg C-1033 Capsaicin Description : Excitant of peripheral sensory nerves endings. 100 mg C-1095 Capsazepine Description : Analog of capsaicin that acts as a specific capsaicin antagonist. 25 mg C-1035 Carazostatin, Streptomyces chromofuscus Description : Potent inhibitor of lipid peroxidation induced by free radicals in rat brain homogenates and mouse plasma. 100 μg C-1207 Carbenicillin.Disodium Description : Semi-synthetic antibiotic used for gene expression research utilizing carbenicillin-resistant plasmids. 1 g C-1385 Carbonyldiimidazole, CDI Product name : Carbonyldiimidazole, CDI 500 g C-1227 Carboxy-PTIO Description : A water soluble and stable nitric oxide scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO). The inhibitory effects were almost 2-fold stronger than those of NMMA or NOARG. 10 mg C-1185 Carboxyfluorescein diacetate (CFDA) Product name : Carboxyfluorescein diacetate (CFDA) 100 mg C-1391 Carnosic acid Description : Naturally-occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Isolated from Rosmarinus officinalis. 50 mg C-1213 Carnosol Description : Naturally-occurring phenolic compound with antioxidant properties. Inhibits the formation of tumors in mouse models or carcinogenesis caused by irritants such as PMA. 1 mg C-1211 Caspase 2, Human, Recombinant, Active Product name : Caspase 2, Human, Recombinant, Active 25 U C-1231 Caspase-1 (Human) Description : Immunogen: Peptide corresponding to amino acids 390-404 of ICEα. Purified rabbit IgG. Specificity: Human ICEα; recognizes a sequence contained in all isoforms of the human protein. Formulation: Purified IgG rabbit antiserum in 1 ml of 0.05 M Sodium Phosphate buffer containing 0.1 % Sodium Azide and 0.2% gelatin. Does not cross-react with mouse Caspase-1. Application: IHC & WB. 100 μg C-1101 Caspase-1 ELISA Kit Description : Suitable for the measurement of caspase-1 in cell culture supernatants, plasma, and human serum and biological samples. 80 Tests; Sensitivity: 5 pg/ml. Quantity: 96 wells (~80 tests). 1 Kit C-1042 Caspase-1 Inhibitor (Aldehyde) Description : Reversible and cell permeable inhibitor of caspase-1. 1 mg C-1001 Caspase-1 Inhibitor (Aldehyde) Description : A potent, selective and reversible inhibitor of caspase-1. Strongly inhibits anti-Fas induced apoptosis. 1 mg C-1047 Caspase-1 Inhibitor (Aldehyde) Description : Reversible, potent inhibitor of caspase-1, and caspase-5. 1 mg C-1107 Caspase-1 Inhibitor (Biotin) Description : Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4. 1 mg C-1003 Caspase-1 Inhibitor (Chloromethylketone) Description : Inhibitor of Fas-mediated apoptosis. Cell permeable and irreversible caspase-1 inhibitor. 1 mg C-1099 Caspase-1 Inhibitor (Fluoromethylketone) Description : Highly specific, cell permeable inhibitor of caspase-1 like proteases. 1 mg C-1089 Caspase-1 Inhibitor (Fluoromethylketone) Description : Cell permeable inhibitor of caspase-1 and -4. More potent for caspase-1. 1 mg C-1235 Caspase-1 Inhibitor (Fluoromethylketone) Description : Inhibitor of caspase-1 1 mg C-1239 Caspase-1 Inhibitor III Description : Inhibits caspases. Also prevents apoptosis caused by various cytotoxic agents. Irreversible, Cell-Permeable. 10 mg C-1079 Caspase-1 Inhibitor V Description : A highly selective, competitive and irreversible caspase-1 inhibitor. Cell-Permeable. 1 mg C-1081 Caspase-1 Inhibitor VI (Z-VAD-FMK) Description : Inhibits apoptosis promoted by diverse stimuli. Irreversible. Cell-Permeable. 1 mg C-1077 Caspase-1 Substrate (AFC) Description : Cell-Permeable. Fluorogenic caspase-1 substrate. (Fluorogenic; Ex:400, Em:505) 1 mg C-1065 Caspase-1 Substrate (Chromogenic) Description : Caspase-1 substrate. (Chromogenic: λ max:400). 5 mg C-1041 Caspase-1 Substrate (Chromogenic) Description : Substrate for caspase-1 with increased of cell permeability. (Chromogenic: λ max:400) 5 mg C-1049 Caspase-1 Substrate (Chromogenic) Description : Substrate for caspase-1, -4 and -5. Most potent for caspase-1. (Chromogenic: λ max:400). 1 mg C-1241 Caspase-1 Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-1 5 mg C-1009 Caspase-1 Substrate (Fluorogenic) Description : Caspase-1 substrate with optimum tetropeptide sequencing for highly efficient cleavage. (Fluorogenic; Ex: 380, Em: 460). 1 mg C-1043 Caspase-1 Substrate (Mca) Description : Specific fluorescent substrate used for determining caspase-1. (Fluorogenic; Ex: 325, Em 392) 1 mg C-1087 Caspase-1, (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 129-152 of human caspase-1. Specificity: Recognizes human, mouse and rat procaspase-1 and the 20 kDa cleaved product. 100 μg C-1329 Caspase-1, Human, Recombinant, Active Description : Recombinant active human caspase-1 produced in bacteria. Specific Activity: ~8000 units/mg. Source: Produced in bacteria. Reconstitution: Reconstitute with PBS to 1unit/µl. 25 U C-1229 Caspase-10 Description : Source: Rabbit. Specificity: raised against human caspase-10 (C-terminal peptide): no Crossreactivity with the Mch4 form of caspase-10. Detects a 59 kDa band. Application: IHC, WB. 100 μg C-1181 Caspase-10/a (Human) (Active) (Rec.) Description : Expressed in E. coli. One unit of rec. caspase-10/1 is the enzyme activity that cleaves 1 nmole of the caspase substrate IETD-pNA per hour at 37°C in a buffered solution. 25 Units C-1325 Caspase-10/b (Human) (Active) (Rec.) Description : Expressed in E. coli One unit of the rec. caspase -10/b is the enyme activity that cleaves 1nmole of the caspase substrate IETD-pNA per hour at 37°C in a buffered solution. 25 Units C-1327 Caspase-12 (IN) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 100-116 of mouse caspase-12. Specificity: Recognizes human, mouse and rat caspase-12 (51kDa). Application: WB. 100 μg C-1359 Caspase-12 (NT) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 2-17 of mouse caspase-12. Specificity: Recognizes human, mouse and rat caspase-12 (51kDa). Application: WB. 100 μg C-1361 Caspase-14 Description : Specificity: Recongnizes mouse caspase-14. Detect a band of ~30KDa by WB. Clone: 80A1585. Isotype: Mouse IgG1. Application: WB. 100 μg C-1193 Caspase-14 (70A1426) Description : Immunogen: Synthetic peptide corresponding to aa 2-18 of mouse caspase-14. Specificity: Recognizes human and mouse caspase-14. Isotype: Mouse IgG1. Application: WB. 100 μg C-1363 Caspase-2 (10C6) Description : Immunogen: Poly-His epitope-tagged p19 fragment of human recombinant caspase-2. Specificity: Recognizes an epitope in the p19 subunit of human, mouse rat, monkey and dog caspase-2. Isotype: Rat IgG2a. 100 μg C-1331 Caspase-2 (11B4) Description : Immunogen: Poly-His epitope-taged p19 fragment of human recombinant caspase-2. Specificity: Recognizes an epitope in the P19 subunit of human, mouse, rat, monkey and dog caspase-2. Isotype: Rat IgG2a. 100 μg C-1333 Caspase-2 Inhibitor (Aldehyde) Description : Reversible inhibitor of caspase-2. 1 mg C-1061 Caspase-2 Substrate (Chromogenic) Description : Substrate of caspase-2. (Chromogenic: Iambda max: 400). 5 mg C-1093 Caspase-2 Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-2. (Floorogenic; Ex: 380, Em: 460) 1 mg C-1113 Caspase-3 (Active) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide around the cleavage site of human caspase-3. Specificity: Recognizes human, mouse and rat active caspase-3. 100 μg C-1337 Caspase-3 (Human) (31A1067) Description : Immunogen: Full length human recombinant caspase-3. Specificity: Recognizes human procaspase-3 and cleaved 12 and 17KDa catalytic subunits. Isotype: Mouse lgG1. 100 μg C-1335 Caspase-3 (Human) (Active) (Rec.) Description : Expressed in E. coli. One unit of rec. caspase-3 is the enzyme activity that cleaves 1 nmole of the caspase substrate DEVD-pNA per hour at 37°C in a buffered solution. 25 Units C-1303 Caspase-3 (Human) (Rec.) Description : Expressed in E. coli. Application: very useful in studying mechanisms of caspase activation and regulation, as well as in investigating cascades of caspase-3 mediated signal transduction pathways. 5 μg C-1299 Caspase-3 (Human) (Rec.) Description : Expressed in E. coli. The rate of caspase-3 enzymatic hydrolysis can be measured by the re;ease of AMC from the caspase substrate Ac-DEVD-AMC as emission at 440 nm and excitation at 380 nm. 5 μg C-1301 Caspase-3 (Rat) (Active) (Rec.) Description : Specific Activity: ~350U/ug. One unit is defined as the amount of enzyme that cleaves 1nmole of the caspase substrate Z-DEVD-AMC per hour at 20°C. During the initiation of apoptosis the procaspase-3 is processed at aspartate residues to form the active enzyme. Includes both the proenzyme and the processed form. 5 μg C-1305 Caspase-3 Control Peptide Product name : Caspase-3 Control Peptide 1 mg C-1137 Caspase-3 Inhibitor (Aldehyde) Description : Potent, specific and competitive inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3, an event, which occurs at the on set of apoptosis. Also inhibits Caspase-7. Reversible. 1 mg C-1117 Caspase-3 Inhibitor (Aldehyde) Description : Specific inhibitor of caspase-3. Together with Caspase-6 inhibitor this inhibitor has been used to dissect the pathway of caspase activation in Fas-stimulated Jurkat cells. Reversible. 1 mg C-1121 Caspase-3 Inhibitor (Aldehyde) Description : Caspase-3 inhibitor with increased cell permeability. 1 mg C-1123 Caspase-3 Inhibitor (Fluoromethylketone) Description : Cell-permeable, Non-cytotoxic and irreversible inhibitor of caspase-3. 1 mg C-1125 Caspase-3 Processing Enzyme Inhibitor (Fluoromethylketone) Description : Cell permeable and irreversible inhibitor of caspase-3 processing enzymes. 1 mg C-1143 Caspase-3 Processing Enzyme Inhibitor (Fluoromethylketone) Description : Cell permeable and irreversible inhibitor of caspase-3 processing enzymes. 1 mg C-1249 Caspase-3 Processing Enzyme Inhibitor I (Aldehyde) Description : Inhibitor of caspase-3 processing enzymes. This peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). It blocks the formation of the p17 subunit. Induces accumulation of 32 kDa precursor. 1 mg C-1139 Caspase-3 Processing Enzyme Inhibitor II (Aldehyde) Description : Inhibitor of caspase-3 processing enzymes. This peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and induces accumulation of the p20 peptide.. 1 mg C-1141 Caspase-3 Processing Enzyme Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-3 processing enzymes. Peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). 1 mg C-1145 Caspase-3 Processing Enzyme Substrate I (Chromogenic) Description : Substrate for caspase-3 processing enzymes with increased cell permeability. Peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). 1 mg C-1149 Caspase-3 Processing Enzyme Substrate II (Chromogenic) Description : Substrate for caspase-3 processing enzymes. Peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). 1 mg C-1147 Caspase-3 Processing Inhibitor II (Aldehyde) Description : This peptide corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide. 1mg C-1247 Caspase-3 Processing Substrate I (Chromogenic) Description : Substrate for caspase-3 processing and granzyme B with increased cell permeability. 1 mg C-1255 Caspase-3 Processing Substrate II (Chromogenic) Description : Substrate with increased cell permeability; corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 172-175). 1 mg C-1253 Caspase-3 Substrate (AFC) Description : Fluorogenic substrate for caspase-3. 1 mg C-1127 Caspase-3 Substrate (Chromogenic) Description : Substrate for caspase-3. 1 mg C-1129 Caspase-3 Substrate (Chromogenic) Description : Substrate of caspase-3 with increased cell permeability. 1 mg C-1131 Caspase-3 Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-3. The sequence is based on the PARP cleavage site Asp216 for caspase-3. 1 mg C-1133 Caspase-3 Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-3. AMC has an excitation maximum of 380nm and an emission maximum of 460nm. 1 mg C-1243 Caspase-3, Human, Active, Recombinant Description : Active enzyme purified from E.coli. The rate of caspase enzymatic hydroysis can be measured by release of AMC from the Ac-DEVD-AMC caspase substrate as emission at 440 nm upon excitation at 380 nm using a spectrofluorometer. Concentration: 5 µg Protein in 25 µl Buffer. Formulation: 5 µg Buffered in 50 mM TRIS (pH 8.0) with 100 mM Sodium Chloride and 50 mM Imidazole 5 μg C-1115 Caspase-3- Inhibitor (Biotin) Description : Highly specific, affinity reagent for caspase-3. Useful for the purification or extract depletion of caspase-3 in conjunction with streptavidin conjugates. 1 mg C-1119 Caspase-4 (Human) (Active) (Rec) Description : Recombinant active human Caspase-4 produced in bacteria. One unit of rec. caspase-4 is the enzyme activity that cleaves 1 nmole of the caspase substrate WEHD-pNA per hour at 37°C in a buffered solution. 25 Units C-1307 Caspase-4 Inhibitor (Aldehyde) Description : Inhibitor for caspase-4. Reversible. Also inhibits Caspase-5. 1 mg C-1151 Caspase-4 Inhibitor (Aldehyde) Product name : Caspase-4 Inhibitor (Aldehyde) 1 mg C-1257 Caspase-4 Substrate (AFC) Description : Sensitive fluorogenic substrate for caspase-4. Fluorogenic; Ex: 400, Em max. 505. 1 mg C-1157 Caspase-4 Substrate (Chromogenic) Description : Substrate for caspase-4. Chromogenic; λ max: 400. 1 mg C-1153 Caspase-4 Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-4 Fluorogenic; EX: 380, Em max. 460. 1 mg C-1155 Caspase-5 (Human) (Active) (Rec) Description : Active enzyme produced in bacteria. One unit of rec. caspase-5 is the enzyme activity that cleaves 1 nmole of the caspase substrate WEHD-pNA per hour at 37°C in a buffered solution. 25 Units C-1309 Caspase-5 (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 159-176 of human caspase-5. Specificity: Recognizes human, mouse, rat, rabbit, bovine, monkey and hamster procaspase-5 and two cleavage intermediates. 100 μg C-1339 Caspase-6 (Human) (Active) (Rec.) Description : Expressed in E. coli. One unit of rec. caspase-6 is the enzyme activity that cleaves 1 nmole of the caspase substrate VEID-pNA per hour at 37°C in a buffered solution. 25 Units C-1313 Caspase-6 (Human) (B93-4) Description : Immunogen: Synthetic peptide corresponding to aa 271-285 of human caspase-6. Specificity: Recognizes human procaspase-6 and active caspase-6. Isotype: Mouse IgG1. 100 μg C-1341 Caspase-6 (Human) (Rec.) Description : Expressed in E. coli. The rate of caspase-6 enzymatic hydrolysis can be measured by the release of AMC from the caspase substrate Ac-DEVD-AMC as emission at 440 nm and excitation at 380nm. 5 μg C-1311 Caspase-6 Inhibitor (Aldehyde) Description : Inhibitor of caspase-6. Reversible. Also inhibits Caspase 8 and 10. 1 mg C-1161 Caspase-6 Inhibitor (Fluoromethylketone) Description : Cell permeable and irreversible inhibitor of caspase-6. 1 mg C-1163 Caspase-6 Substrate (Chromogenic) Description : Substrate for caspase-6. Chromogenici; λ max. 400. 1 mg C-1165 Caspase-6 Substrate (Fluorogenic) Description : Substrate for capsase-6. Fluorogenic; Ex. 380, Em max, 460. Also substrate for Caspase-9 and 10. 1 mg C-1167 Caspase-6, Human, Recombinant, Purified Description : Active enzyme purified from E. coli. The rate of caspase enzymatic hydrolysis can be measured by release of AMC from the Ac-DEVD-AMC caspase substrate, emission at 440 nm excitation at 380 nm using a spectrofluorometer. Concentration: 5µg Protein in 25µl Buffer. Formulation: 5µg Buffered in 50mM TRIS (pH 8.0) with 100mM Sodium Chloride and 50mM Imidazole. 5 μg C-1159 Caspase-7 (Active) (Purified) Description : Source: Rabbit. Immunogen: synthetic peptide around the cleavage site of human caspase-7. Specificity: Recognizes human, mouse and rat caspase-7 p20 subunit. Does not cross-react with procaspase-7. Application: ICC, WB 100 μg C-1345 Caspase-7 (Human) (Active) (Rec.) Description : Express in E. coli. One unit of rec. caspase-7 is the enzyme activity that cleaves 1 nmole of the caspase substrate DEVD-pNA per hour at 37°C in a buffered solution. 25 Units C-1315 Caspase-7 (Human) (Rec.) Description : Expressed in E. coli. The rate of caspase-7 enzymatic hydrolysis can be measured by the release of AMC from the caspase substrate Ac-DEVD-AMC as emission at 440 nm and excitation at 380nm. 5 μg C-1317 Caspase-7 (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 264-279 of human caspase-7. Specificity: Recognizes human, mouse rat, rabbit, monkey, dog, pig, sheep and hamster procaspase-7 and the p10 subunit of active caspase-7. 100 μg C-1343 Caspase-7, Human Recombinant, Purified Description : Active enzyme purified from E.coli. The rate of caspase enzymatic hydrolysis can be measured by release of AMC from the Ac-DEVD-AMC caspase substrate, emission at 440 nm excitation at 380 nm using a spectrofluorometer. Concentration: 5µg Protein in 25µl Buffer. Formulation: 5µg Buffered in 50mM TRIS (pH 8.0) with 100mM Sodium Chloride and 50mM Imidazole. 5 μg C-1169 Caspase-8 (Human) (12F5) Description : Immunogen: Recombinant human caspase-8 fusion protein. Specificity: Recognizes human procaspase-8 (p55/54), the intermediate cleavage products of 43kDa and 41Da and the p18 active subunit of caspase-8. Isotype: Mouse lgG2b. Application: IP, WB. 100 μg C-1349 Caspase-8 (Human) (Active) (Rec.) Description : Expressed in E. coli. One unit of rec. caspase-8 is the enzyme activity that cleaves 1 nmole of the caspase substrate IETD-pNA per hour at 37°C in a buffered solution. 25 Units C-1321 Caspase-8 (Human) (Rec.) Description : Expressed in E. coli. The rate of caspase-8 enzymatic hydrolysis can be measured by the release of AMC from the caspase substrate Ac-DEVD-AMC as emission at 440 nm and excitation at 380 nm. 5 μg C-1319 Caspase-8 (Human) C15 Description : Immunogen: Recombinant human caspase-8 corresponding to aa 181-478. Specificity: Recognizes the p18 subunit of human caspase-8. Isotype: Mouse IgG2b. Application: ICC, IP, WB. 50 μg C-1351 Caspase-8 Fluorometric Assay kit Description : Based on detection of AFC after cleavage from the labelled substrate IETD-AFC. IETD-AFC emits blue light, upon cleavage free AFT will emit yellow-green fluorescence, this can be measured using fluorometer or fluorecence microtiter plate ready. 25 Tests C-1415 Caspase-8, Human Recombinant, Purified Description : Active enzyme purified from E.coli. The rate of caspase enzymatic hydrolysis can be measured by release of AMC from the Ac-DEVD-AMC caspase substrate as emission at 440 nm upon excitation at 380 nm using a spectrofluorometer. 5 μg C-1171 Caspase-9 (Active) (Purified) Description : Source: Rabbit. Immunogen: synthetic peptide around the clevage site of human caspase-9. Specificity: Recognizes human and rat cleavage fragment (37kDa). Does not cross-react with procaspase-9. Application: ICC, IP, WB. 100 μg C-1355 Caspase-9 (Human) Description : Source: Rabbit. Immunogen: Recombinant histidine-tagged human caspase-9. Specificity: Recognizess human procaspase-9 and the p37/p35 cleavage products of activated caspase-9. Application: IP, WB. 100 μl C-1357 Caspase-9 (Human) (Active) (Rec.) Description : Expressed in E. coli. One unit of rec. caspase-9 is the enzyme activity that cleaves 1 nmole of the caspase substrate LEHD-pNA per hour at 37°C in a buffered solution. 25 Units C-1323 Caspase-9 (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 287-306 of human caspase-9. Specificity: Recognizes human, mouse, rat, rabbit, monkey, dog, pig, bovine and hamster procaspase-9 (52kDa) and a cleaved fragment (32kDa). Application: WB 100 μg C-1353 Caspase-9 Fluorometric Assay kit Description : Based on the detection of AFC after cleavage from labelled substrate LEHD-AFC. 25 Tests C-1417 Caspase-9 Inhibitor (Aldehyde) Description : Inhibitor of caspase-9, Reversible. 1 mg C-1173 Caspase-9 Inhibitor (Fluoromethylketone) Description : Cell permeable and irreversible inhibitor of caspase-9. 1 mg C-1175 Caspase-9 Substrate (Chromogenic) Description : Substrate for caspase-9, Chromogenic; λ max: 400. 1 mg C-1177 Caspase-9 Substrate (Fluorogenic) Description : Fluorogenic substrate for caspase-9, caspase-4 and caspase-5. Most potent for caspase-9. 1 mg C-1179 Caspase-9, Human, Recombinant, Active Description : Active enzyme purified from E. coli. The expressed caspase-9 spontaneously undergoes autoprocessing to yield the subunits characteristic of the native enzyme. This product is useful in screening caspase inhibitors for pharmaceutical Applications. Specific Activity: ~400 units/mg. 25 U C-1191 Catenin (aa27-37) Description : Specificity: To nuclear β-Catenin in human, mouse, rat and dog. Clone: 8E4, Isotype: Mouse IgG1. Application: ELISA, ICC, IP, WP. Includes positive control. 100 μg C-1202 Cathepsin W / Procathepsin W (Human) (CW 39-1B10) Description : Immunogen: Purified recombinant human procathepsin W. Clone: CW 39-1B10. Isotype: Mouse IgG2b. 200 μg C-1378 Cathepsin W / Procathepsin W (Human) (CW 39-2B6) Description : Immunogen: Purified recombinant human procathepsin W. Clone: CW 39-2B6. Isotype: Mouse IgG2b.G313 200 μg C-1379 Caveolin-2 Description : Antibody to Caveolin-2. Caveolin-2 has been shown to positively regulate caveolin-1-dependent caveolae biogenesis and that this phenomenon is contingent on the phosphorylation of caveolin-2 on serine 23 and 36. Source: Rabbits were immunized with a synthetic peptide based on amino acid residues 18-31 of caveolin-2 phosphorylated on Ser-23. Cross-Reactivity: Human. Application: Western Blot (0.2 μg/ml – 1.0 μg/ml). 50 μg C-1393 Caveolin-2 Description : Source: Rabbits were immunized with a synthetic peptide based on amino acid residues 18-31 of caveolin-2 phosphorylated on Ser-23. Cross-Reactivity: Human. Application: Western Blot (0.2 μg/ml – 1.0 μg/ml). Caveolin-2 has been shown to positively regulate caveolin-1-dependent caveolae biogenesis and that this phenomenon is contingent on the phosphorylation of caveolin-2 on serine 23 and 36. 50 μg C-1393 Caveolin-2 Phospho-Ser23 Description : Source: Rabbits were immunized with a synthetic peptide based on amino acid residues 18-31 of caveolin-2 phosphorylated on Ser-23. Cross-Reactivity: Human. Application: Western Blot (0.1 – 0.5 μg/ml). Caveolin-2 has been shown to positively regulate caveolin-1-dependent caveolae biogenesis and that this phenomenon is contingent on the phosphorylation of caveolin-2 on serine 23 and 36. 50 μg C-1395 Caveolin-2 Phospho-Ser36 Description : Source: Rabbits were immunized with a synthetic peptide based on amino acid residues 32-45 of caveolin-2 phosphorylated on Ser-36. Cross-Reactivity: Human. Application: WB (0.1 – 1.0 μg/ml). Caveolin-2 has been shown to positively regulate caveolin-1-dependent caveolae biogenesis and that this phenomenon is contingent on the phosphorylation of caveolin-2 on serine 23 and 36. 50 μg C-1397 Cerulenin Description : Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, thus inhibiting protein acylation. 5 mg C-1375 CHAPS, High Purity Description : Zwitterionic detergent that combines the features of bile salts and N-alkyl sulfobetaines. Can be easily removed from gels or protein solutions by dialysis across a membrane. 10 gm C-1019 Chartreusin Description : Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents. 5 mg C-1371 Chelerythrine Chloride Description : Potent and selective inhibitor of Protein Kinase C. 5 mg C-1021 Chemokine Receptor D6 (Human) (Purified) Description : Source: Goat. Immunogen: Synthetic peptide (CLATEDAD-SENSSFYYYDYLDEVAFML) corresponding to N-terminal (aa 10-35) human bets-chemokine receptor D6. Specificity: Recognizes human β-chemokine receptor D6. Application: Immunocytochemistry (dilution 1:400), Western Blot (dilution 1:1000). 100 μl C-1267 Chloramphenicol EIA Description : Chloramphenical (CPC) is an effective antibiotic against a wide range of bacteria and is especially useful in the treatment of g negative infections in cattle. The sensitivity of the Chloramphenicol EIA kit is excellent, and is well suited for the determination of Chloramphenicol in shrimp sample extracts. A Zero tolerancel level has been established by the Food and Drug Administration for chloramphenical residues in both domestic and imported animal products. 1 Kit C-1273 Chlorothricin Description : Unusual macrolide antibiotic. Shows inhibitory activity against cholesterol biosynthesis from mevalonate. Please inquire C-1400 Chromomycin A3 Streptomyces Griseus Description : Antibiotic produced by Streptomyces grieus that inhibits RNA synthesis. Also used as a fluorescent dye to determine DNA concentrations. 10 mg C-1023 Chrysomycin A Description : Topoisomerase II Inhibitor. Inhibits the catalytic activity of human topoisomerase II. Exhibits antitumor activity against human cell lines K562, HT29, MCF7, PC6, MKN28. Please inquire. C-1410 Chrysomycin B Description : Topoisomerase II Inhibitors. Inhibitors of the catalytic activity of human topoisomerase II. Exhibits antitumor activity against human cell lines K562, HT29, MCF7, PC6, MKN28. Please inquire. A-1412 Ciglitazone Description : Selective PPARy agonist (EC50=3uM). 1 mg C-1201 Citrinin, Penicillium citrinum Description : Mycotoxin which induces mitochondrial permeability transition. Also inhibits microtubule polymerization. 5 mg C-1109 CK-2 assay kit Description : Useful for determining the activity of CK-2 or related protein serine kinase. Can be used to evaluate the effect of a test substance on CK-2 activity or to identify new physiological substrates of the enzyme. Kit includes directional insert, and contains solutions of MgATP, casein, assay buffer, and purified CK-2 sample. I Kit C-1271 Clobenpropit.Dihydrobromide, VUF 9153 Description : Extremely potent and selective Histamine H3 antagonist. Effective as an anticonvulsant. 10 mg C-1015 Clofibrate Description : Activates PPARa and induces cytochrome P450 4A1 and 4A3. 1 g C-1203 Clozapine Description : Antipsychotic with greater affinity for D4 dopamine receptor versus D2 or D3 dopamine receptors. 100 mg C-1045 Clusterin (Human) (CLI-9) Description : Immunogen: Purified human clusterin. Specificity: Recognizes human clusterin (TRDM-2). Clone: CLI-9. Isotype: Mouse IgG1. Application: ICC, IHC (FS), IP, WB. 100 μg C-1293 CNQX Description : Potent kainate / quisqualate receptor antagonist. 10 mg C-1053 Cochlioquinone A Description : Newly isolated microbial agent. Demonstrates anti-angiogenic activity. Isolated from Bipolaris zeicola. Please inquire. C-1401 Cochlioquinone B Description : Newly isolated microbial agent. Please inquire. C-1403 Coelenterazin ip Product name : Coelenterazin ip 50 μg C-1285 Coelenterazin n Description : An intracellular luminophore that is useful for measuring changes in superoxide and Ca2+ levels (in millimolar amounts for relatively longer periods of time) in cells transfected with apoaequorin cDNA. 50 μg C-1287 Coelenterazin, 2-methyl Product name : Coelenterazin, 2-methyl 50 μg C-1289 Coelenterazine Description : Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. When oxidized by oxygen it illuminates blue light at 446nm when Ca2+ binds to the complex. 50 μg C-1212 Coelenterazine cp Product name : Coelenterazine cp 50 μg C-1275 Coelenterazine f Description : A highly sensitive and specific intracellular luminophore that is useful for measuring changes in superoxide and Ca2+ levels in cells transfected with apoaequorin cDNA.Exhibits nearly 20-fold greater luminescence intensity 50 μg C-1277 Coelenterazine fcp Product name : Coelenterazine fcp 50 μg C-1279 Coelenterazine hcp Description : A highly sensitive and a specific intracellular luminophore that is useful for measuring changes in superoxide and Ca2+ levels in cells transfected with apoaequorin cDNA. Exhibits about 500-fold greater luminescence intensity. 50 μg C-1281 Coelenterazine I Product name : Coelenterazine I 50 μg C-1283 Coelenterazine Sampler Kit Product name : Coelenterazine Sampler Kit 1 Kit C-1291 Colchicine Description : Depolymerizes microtubules. Inhibits tubulin polymerization. Induces apoptosis. 1 g C-1164 Concanamycin A, Streptomyces sp. Description : Antibiotic which is a specific inhibitor of vacuolar H+ ATPase. 100 μg C-1057 cPK Assay Kit Description : Useful for determining the activity of cPK or related protein serine/threonine kinase. Can be used to evaluate the effect of a test substance on cPK activity or to identify potential new physiological substrates of the enzyme. Kit includes directional insert, and contains solutions of MgATP, protamine sulfate, assay buffer, and purified cPK sample. 1 Kit C-1269 Cyanopaullone Description : Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. 9-cyanopaullone is a potent inhibitor of CDK1/cyclin B (IC50=0.024uM). 1 mg C-1205 Cycloheximide, Streptomyces griseus Description : An antibiotic produced by Streptomyces griseus, which acts as an inhibitor of protein synthesis in eukaryotes but not prokaryotes. In molecular biology applications it is used in the selection of wild type CAN1, CYH2 and LYS2 genes. Cycloheximide's selectivity makes it active against yeast and fungi but tolerated by most bacteria. This feature has allowed brewer’s to suppress the growth of culture yeast and detect unwanted bacteria. Cycloheximide also used to induce apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types. Additionally, plant researchers have shown it to stimulate ethylene production in fruit and leaves. 1 g C-1189 Cyclopamine Description : Cyclopamine is a steroidal alkaloid that blocks sonic hedgehog signaling. It demonstrates teratogenic properties, as well as, promising anti-tumor properties. 1 mg C-1405 Cyclopiazonic acid, Penicillium cyclopium Description : Reversible inhibitor of endoplasmic reticulum Ca2+ ATPase. Does not increase IP3 levels. 10 mg C-1025 Cycloserine, Streptomyces orchidaceus Description : Antibiotic which inhibits cell wall synthesis. Used as anti-tuberculosis agent. Also shown to be a cognitive enhancer. 5 kg C-1067 Cyclosporin A, Fusarium solani Description : Potent immunosuppressor. Inhibitor of the mitochondrial permeability transition pore (MPTP) preventing necrosis in several models. Isolated from Fusarium solani. 100 mg C-1199 Cyclothiazide Description : Modifies the gating for non-NMDA channels. 10 mg C-1073 Cystatin A (Human) (WR 23/2/3/3) Description : Immunogen: Purified human cystatin A (Stefin A; ACPI). Clone: WR 23/2/3/3. Isotype: Mouse IgG1. Specificity: Recognizes human cystatin A. Does not cross-react with cystatin B. 200 μg C-1383 Cytochalasin A Description : A fungal metabolite that acts as an inhibitor of glucose transport and actin polymerization. 5 mg C-1111 Cytochalasin B, Helminthosporium dematioideum Description : A fungal metabolite that acts as a microtubule inhibitor. Also induces cellular DNA Fragmentation. 5 mg C-1027 Cytochalasin C Description : A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. 1 mg C-1200 Cytochalasin D, Zygusporium mansonii Description : A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. Also shown to protect Hippocampal neurons from Amyloid β-Peptide Toxicity. 1 mg C-1070 Cytochalasin E, Aspergillus clavatus Description : A fungal metabolite that inhibits angiogenesis & tumor growth. Enhances PKC-dependent process of secretion. Does not inhibit glucose transport. 1 mg C-1197 Cytochrome c ELISA Kit Description : For measurement of human cytochrome c in cell culture lysates, human whold blood or serum. Sensitivity: 0.08ng/ml. 1 Kit C-1365 Cytochrome c Releasing Apoptosis Assay Kit (BioVision) Description : For detecting cytochrome c translocation from mitochondria into cytosol during apoptosis. The kit provides an easy-to-use procedure and reagents for separating a mitochondria-enriched fraction from cytosol. Cytochrome c released from mitochondria into cytosol is determined by WB using the cytochrome c antibody provided in the kit. The procedure is simple, straightforward and requires no ultracentrifugan. 100 tests C-1367 Cytosol Fractionation Kit Description : For an effective isolation of a highly enriched mitochondrial fraction from the cytosol fraction of various mammalian cells including both apoptotic and nonapoptotic cells. The enriched mitochondrial and Cytosolic fractions can be used to study apoptosis and signal transduction pathways by detecting translocations of factors of interest between the two fractions by ELISA, WB or other assays. The core kit contains unique formulations of buffers and reagent that allow isolation of mitochondria and cytosol in two easy steps. No ultracentrifugations are required. 1 kit C-1369 DAF-2 Description : Highly sensitive fluorescent probe for the real-time detection of nitric oxide (NO) in vivo. In the cell, the product reacts rapidly with NO in the presence of O2 to form the highly fluorescent compound triazolofluorescein (DAF-2T, Ex 495nm; Em 515nm). 1 mg D-1147 DAF-2 DA, Cell Permeable Description : Cell permeable analog of DAF-2 that is hydrolyzed to DAF-2 by intracellular esterases. Can be used in fluorescence microscopy to measure real-time changes in NO levels in vivo. 1 mg D-1149 Daidzein Description : Inactive analog of the tyrosine kinase inhibitor genistein. 25 mg D-1019 Dansyl-NECA Description : Fluorescent ligand for adenosine receptors with a marked selectivity for the A1 receptor subtype. Has been successfully applied in fluorescence microscopy assays. 500 μg D-1151 Daxx (Human) (CT) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 722-740 (T722 SVATQCDPE-EIIVLSDSD470) of c-terminal human Daxx. Specificity: Recognizes human Daxx. Detects a 120kDa band by WB. A novel Fas binding protein was cloned from human and mouse and designaed Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. 100 μg A-1242 Daxx (Human) (Daxx-01) Product name : Daxx (Human) (Daxx-01) Purified 100 μg D-1175 DCG-IV Description : Presynaptic depressant. Product is highly potent group II mGluR agonist 1mg D-1296 DD1 Description : Nitric Oxide (NO) donor which is cell permeable with vasodilator effects. Guanylylcy clase activator. 10 mg D-1083 DD2 Description : Nitric Oxide (NO) donor which is cell permeable with vasodilator effects. Guanylycy clase activator 10 mg D-1085 DEA-NONOate, DEA/NO Description : A Nitric Oxide donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. 50 mg D-1013 Dehydroxy)coelenterazine Description : Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. Shows 20 times higher luminescence than coelenterazine. 50 μg C-1209 Deoxy-3-bromo-Ins(1,4,5)P3. 6Na Description : Exhibits very strong ligand binding affinity to the Ins(1,4,5)P3 receptor of bovine adrenal cortex membranes and acts as a strong agonist in releasing calcium from saponin permeabilized SH-Sy5Y human neuroblastoma cells. D-1107 Deoxy-Ins(1,4,5)P3. 6Na Description : Equal to Ins(1,4,5)P3 in releasing intracellular calcium. The 3-position is blocked by fluorine so it can not be converted to Ins(1,3,4,5)P4 by the action of 3-kinases. Useful for studying the pathways in which InsP3 and InsP4 are closely interactive 100 ug D-1109 Deoxy-phophatidylinositol Description : Antimetabolite of phosphatidylinositol-3-phosphate. An inhibitor of cancer cell colony formation. 100 μg D-1113 Deoxymannojirimycin.HCl Description : Potent inhibitor of a-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. 1 mg D-1155 Deoxynojirimycin Description : Antibiotic which acts as an inhibitor of mammalian glucosidases I and II. 1 mg D-1157 Desmethylclozapine Description : A potent and selective 5-HT2C serotonin receptor antagonist. A major metabolite of Clozapine. D-1087 DETA-NONOate, NOC-18 Description : A Nitric Oxide donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. 25 mg D-1015 Dia1 Description : Source: Rabbit. Specificity: Raised against a 81 kDa polypeptide corresponding to human Dia1 aa 727-765 (end of FH1 domain) and 1121-1145 (C-terminal coil), respectfully. Recognizes human and porcine Dia1. Application: WB, IP 100 μl D-1135 Digitonin Description : Non-ionic detergent used to solubilize membrane-bound proteins. 1 gm D-1029 Diltiazem.HCl Description : Blocks slow, or L-type Ca2+ channels; regulates Ca2+ release from intracellular stores in neutrophils. 5 g D-1159 Dimethylphenyl) -1- propyl - piperidine . Hydrochloride Description : Highly selective ligand for the D4 dopamine receptor. 5 mg D-1153 Dioleoyl - sn - glycero - 3 - phospho - L - serine.Na Salt Description : High purity phospholipid utilized for liposome production. 10 mg D-1133 Dioleoyl - sn - glycero - 3 - phosphocholine Description : High purity phospholipid utilized for liposome production. 50 mg D-1131 Dioleoyl - sn - glycero - 3 - phosphoethanolamine Description : High purity phospholipid utilized for liposome production. Useful for the efficient transfection of mammalian cells. 50 mg D-1130 Diphenyleneiodonium chloride Description : Nitric Oxide inhibitor. Binds strongly to flavoproteins. 25 mg D-1011 DLC1 & DLC2 (11F7) Description : Immunogen: Mouse recombinant DLC1. Specificity: Recognizes human and mouse DLC1 and DLC2. Isotype: Rat IgG2a. Application: FC,IP, WB. 100 μg D-1293 DLC1 [LC8; PIN] (10D6) Description : Immunogen: Mouse recombinant DLC1. Specificity: Recognizes human and mouse DLC1. Dese not cross-react with DLC2. Isotype: Rat IgM. Application: FC,WB. 100 μg D-1291 DMAG Description : A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor. 1mg A-1298 DMNQ Description : Redox-cycling agent that induces intracellular superoxide anion formation and depending on the concentration, induces cell proliferation, apoptosis or necrosis. 5 mg D-1143 DMTAP.mesylate Description : Cationic liposomal transfection reagent. 5 mg D-1125 Dnp - Pro - Leu - Gly - Met - Trp - Ser - Arg - OH Description : Substrate for MMP-2 and MMP-9. 5 mg D-1161 DNQX Description : Potent kainate/quisqualate receptor antagonist. 25 mg D-1017 DOTAP.mesylate Description : Synthetic cationic lipid used for DNA and RNA transfections. 5 mg D-1123 DPTA/NONO DPTA NONOate Description : Nitric oxide donor. Half life time in aqueous solution (pH 7.4) at 22°C is 5 hours. 5 mg D-1115 Drugs of Abuse EIA Description : The enzyme immunoassay for Drugs of Abuse is based on the competition between the drug to be assayed and the drug-enzyme conjugate, for binding to antibody directed against the drug, coated onto microtiter wells. The intensity of the color developed is inversely proportional to the concentration of drug in the sample. Therefore, those samples that contain the drug will inhibit binding of the enzyme conjugated to the capture antibody resulting in less color than the negative control. 1 Kit D-1163 DTT Description : Protective agent for SH groups. Used as a reducing agent for proteins and enzymes. Enhances DNA polymerase activity. 5 g C-1029 dup of T1134 Description : Inhibitor of microtubule assembly. T-1150 Dynamin I, (Dyn1) Purified Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 633-647 of rat dynamin I. Sequence is completely conserved in rat, mouse and human dyanamin. Specificity: Recognizes dynamin I in rat brain homogenate (~100 kDa). Application: WB. 100 μl D-1137 Dynamin II, (Dyn2) Purified Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 762-781 of human dynamin II. Specificity: Recognizes dynamin II in human, rat and mouse tissue (~100 kDa). Application: WB. 100 μl D-1139 Dynamin III, (Dyn2) Purified Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 623-639 of rat dynamin III (Dyn3). Specificity: Recognizes dynamin III in human, rat and mouse tissue (~100 kDa). Application: WB. 100 μl D-1141 E-64 Description : Irreversible inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the active cysteine. Effective concentration 1-10uM. 5 mg E-2030 EB-47 Description : Potent PARS Inhibitor 1 mg E-2022 Ebselen Description : An anti-inflammatory, antioxidant compound. Shown to be a neuroprotective agent and an inhibitor of free radical induced apoptosis. 25 mg E-1011 Ecdysone Description : Insect steroid hormone involved in regulating metamorphosis. 1 mg E-1063 EGF, Murine Submaxillary Gland Description : A polypeptide growth factor which stimulates the proliferation of a wide range of epidermal and epithelial cells. 1 mg E-1036 EHNA.HCl Description : Potent inhibitor of adenosine deaminase. 50 mg E-1093 eIF-4E Description : Antiserum to human eIF-4E. Raised in rabbits. Useful for western blotting, for example, with 50 mg bovine liver extracts and the antibody at up to 1:1000 dilution. Effective also for immunoprecipitation. 100 μl E-2016 Elaidylphosphocholine (C18:1, trans) Description : Alkylphosphocholine which acts as an anti-tumor agent. 250 mg E-1110 endoGlyx-1(Human) Description : Anti- EndoGlyx-1 may aid in the characterization and quantification of the angiogenic phase of solid tumors. Clone: H572. Isotyp: Mouse IgG1. 100 μg E-2012 Enniatin B Description : Isolated from Fuzarium orthoceras var. enniatum. 1 mg E-2024 Epigallocatechin gallate Description : Polyphenolic constituent of green tea that possesses potent anti-tumor, anti-inflammatory and antioxidant properties. Isolated from green tea. 50 mg E-2002 Epithelial Cell Adhesion Molecule Description : Specificity: Reacts with human EpCAM (ESA, EGP40, 17-1A antigen, KSA, GA 7333-2), a 40kDa epithelial cell expressed on baso-lateral cell surface in many epithelial tissues. Clone: VU-1D9. Isotype: Mouse IgG1. Application: FC, IHC (FS, PS), IP, WB, FUNC (diffferentiates between mesothelioma and carcinoma) 100 μg E-2006 Epithelial Monocyteactivating Polypeptide II (EMAP II)(Human) Description : Specificity: Reacts with huan EMAP II, EMAP II is specifically induced by apoptosis. Application: ELISA. Endothelial Monocyte Activating Polypeptide (EMAP) II is an anti-angiogenic protein. 100 μg E-2008 Epoxomicin, Synthetic Description : Cell permeable, potent, and selective proteasome inhibitor. More potent than Lactocystin. Inhibits the chymotrypsin-like, trypsin-like, and peptidylglutamyl peptide-hydrolyzing activities of the proteasome. 50 μg E-1098 Epoxyquinone G109 (Racemic) Description : Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase). ((+)-enantiomer) 2 mg E-2020 Equisetin Description : Newly isolated microbial agent. Please inquire. E-2028 Erbstatin Analog Description : Inhibitor of EGF receptor-associated tyrosine kinase. 5 mg E-1096 ET-18-OCH3 Description : Strong anti-tumor agent and anti-cancer agent. Selectively inhibits phosphatidylinositol phospholipase C and induces expression of c-fos, c-jun, and transcription factor AP-1. 50 mg E-1027 Etazolate.Hydrochloride Description : Phosphodiesterase IV inhibitor. 5 mg E-1094 Etoposide Description : Topoisomerase II inhibitor. Widely used apoptosis inducer. 100 mg E-2004 ETYA Description : Inhibits arachidonic acid uptake. Inhibitor of lipoxygenases, cyclooxygenase (COX), phospholipase A2 and cytochrome P450. Modulates Ca2+ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells. 5 mg E-2000 Ewing's Tumor Associated Antigen 16 (ETAA16) (Human) Description : Immungen: Fresh Ewing's tumor tissue (mixture of Ewing's sarcoma tumor and Ewing's tumor cell line VH64). Specificity: Recognizes human Ewing's tumor associated antigen 16 (ETAA16), epitope aa 332-485. Clone: SN 58 1857.15.30. Cross reacts with hepatic tissue in immunohistochemistry. Isotype: Mouse IgG2b. Application: FC, IHC (FS, PS), IP, WB, FUNC (diffferentiates between mesothelioma and carcinoma). 100 μg E-2010 FADD (DD) (12E7) Description : Immunogen: Recombinant mouse FADD. Specificity: Recognizes an epitope in the C terminal death domain (DD) of human and mouse FADD. Isotype: Rat lgG1. 100 μg F-1112 FADD (Mouse) (DD) (7B5) Description : Immunogen: Recombinant mouse FADD. Specificity: Recognizes mouse C-termianl FADD death domain (DD). Isotype: Rat lgG1. 100 μg F-1108 FADD (Mouse) (DED) (7A2) Description : Immunogen: Recombinant mouse FADD. Specificity: Recognizes mouse N-termianl FADD death effector domain (DED). Isotype: Rat lgG1. 100 μg F-1110 Fas (Human) Description : Monoclonal Antibody produced against a recombinant protein. Does not induce apoptosis. 100 μg F-1012 Fas (Human) Description : Monoclonal Antibody produced against a recombinant protein. Prevents apoptosis induced by Actinomycin D and Cycloheximide. 100 μg F-1014 Fas Antigen, Extracellular Fragment (Recombinant) Description : Contains amino acids 1-157 of Fas Antigen sequence. 100 μg F-1018 Fas Ligand (Human) (2C101) Description : Immunogen: Recombinant human FasL. Specificity: Recognizes human FasL. Isotype: Mouse IgG1. Purified 100 μg F-1102 Fas Ligand (Human) (5G51) Description : Specificity: Recognizes human FasL. Isotype: Mouse lgG1. Purified 100 μg F-1100 Fas Ligand (Human) (Alf-2.la) Description : Isotype: Mouse lgG1. Specificity: Recognizes huamn Fas Purified 100 μg F-1106 Fas Ligand (Human) (Mike-1) Product name : Fas Ligand (Human) (Mike-1) Purified 100 μg F-1096 Fas Ligand (Human) (Mike-2) Product name : Fas Ligand (Human) (Mike-2) Purified 100 μg F-1098 Fas Ligand (Mouse) (3C82) Product name : Fas Ligand (Mouse) (3C82) Purified 100 μg F-1104 Fas Ligand (Mouse) (A11) Product name : Fas Ligand (Mouse) (A11) Purified 100 μg F-1092 Fas Ligand (Mouse) (H11) Product name : Fas Ligand (Mouse) (H11) Purified 100 μg F-1094 Fas Ligand, Soluble (Human) (Rec.) Description : Kill Fas-sensitive cells at >50ng/ml. 10 μg F-1072 Fas Ligand, Soluble (Human) (Rec.) Set Description : The set contains 10 μg of rhsFas ligand and 4x50ug of an enhancer which increases the biological activity by approx. 50-fold to a concentration range of 1-5ng/ml. 1 set F-1074 Fas Ligand, Soluble (Human) ELISA Kit Description : The kit is suitable for use in cell culture supernatants, human serum, EDTA and heparintreated plasma, urine, amniotic fluid and other biological fluids. 1 kit F-1076 Fas [CD95] (Death Domain) (Human) (3D5) Product name : Fas [CD95] (Death Domain) (Human) (3D5) Purified 200 μl F-1090 Fas [CD95] (Human) (2R2) Description : Specificity: Recognizes human Fas. Application: induces apoptosis-no cross-linking reqired. Isotype: Mouse lgG3. Purified 100 μg F-1087 Fas [CD95] (Human) (ANC 95.1/5E2) Description : Human CD95 (APO-1/FAS) is a type I cell surface glycoprotein that is strongly upregulated on activated T cells, B cells, NK cells and thymocytes. Liquid. Purified antibody contains 0.5mg/ml gentamycin sulfate; conjugated antibodies contain 0.04% sodium azide. Isotype: Mouse lgG1. Specificity: Recognizes human Fas. Purified 100 μg F-1088 Fas [CD95] (Human) (APO-1-1) Description : induces apoptosis upon cross-linking. Isotype: Mouse lgG1. Specificity: Recognizes human Fas. Purified 100 μg F-1080 Fas [CD95] (Human) (APO-1-3) Description : Induces apoptosis-no cross-linking required Purified 100 μg F-1082 Fas [CD95] (Human) (SM1/23) Description : Immunogen: Human Fas (CD95; APO-1). Specificity: Recognizes human Fas. Application: blocks induction of apoptosis. Purified 100 μg F-1086 Fas [CD95] (SM1/1) Description : Immunogen: Human Fas (CD95; APO-1). Specificity: Recognizes human Fas. Isotype: Mouse IgG2a. Purified 100 μg F-1084 Fas [CD95]: Fc (Human) (Rec.) Description : Specificity: rhFas: binds to and blocks human, mouse and rat Fas ligand. Exerts its inhibitory activity in a concentration range of 20-100ug/ml. 50 μg F-1064 Fas [CD95]: Fc (Human) (Rec.) set Description : The set contains 50ug of rhFas: Fc and 20ug of an enhancer which increases the inhibitory activity by approx. 1 set F-1068 Fas:Fc (Human) (Recombinant) Description : Inhibits human and mouse soluble Fas (sFasL). Kit contains: Fas:Fc (50ug) and Enhancer (20ug) 50 μg F-1034 Fascaplysin (synthetic) Description : Originally isolated from a marine sponge. Selective CDK4 inhibitor (in a ATP competitive manner). 1 mg F-1136 FasLigand Description : ACRP30headless (human) 10 μg F-1064 FasLigand Description : Specificity: rhsSuperFas Ligand recognizes human, mouse and rat Fas. rhsSuperFas Ligand kills sensitive cells at concentrations> 1ng/ml. 5 μg F-1070 FasLigand Description : FasLigand, Soluble (human) (rec.) 10 μg F-1078 Ferutinin Description : Potent Ionophore demonstrating potent estrogen activity. Semisynthetic 5 mg F1140 FFP-18(AM) Description : Cell-permeable, acetoxymethyl ester (AM) derivative of FFP-18 useful as a near-membrane calcium indicator. Excitation max.: 364 nm (low Ca2+) and 335 nm )high Ca2+), Emission max.: 502 nm (low Ca2+) and 490 nm (high Ca2+). 500 μg F-1052 FIAF (Rat) Description : Source: Rabbit. Specificity: Recognizes rat FIAF. Detects a band of ~50kDa by Western blot. Figure: Western blot on FIAF in rat adipose tissue extract using anti-FIAF Pab. Application: Western blot (2µg/ml). 100 μg R-1148 Fibroblast Activation Protein (FAP) (Human)(F11-24) Description : Clone: F11-24 Isotype: Mouse IgG1 Application: FC, IHC, IP, (paraffin sections not recommeded) 100 μg F-1056 FIP-18(AM) Product name : FIP-18(AM) 500 ug F-1054 FK-506 Description : Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein and inhibit the Ca2+-dependent phosphatase and calcineurin. *Melting Point for Monohydrate. 1 mg F-1030 FK409, NOR-3 Description : A Nitric Oxide donor, useful for reliable generation of Nitric Oxide (NO). The half-life of NO release at 24°C is approx. 30 minutes in aqueous solution at pH 7.4. 10 mg F-1010 FLIP (Dave-2) Description : Immunogen: Full-length recombinant human FLIP. Specificity: Recognizes an epitope present in both short and long splic variants of human and mouse FLIP. Clone: Dave-2. Isotype: Rat lgG2a. 100 μg F-1114 FLIP (Human) (NF6) Description : Immunogen: Recombinant human FLIP corresponding to aa 1-194 fused to GST. Specificity: Recognizes short and long splice variants of human FLIP. Isotype: Mouse lgG1. 50 μg F-1118 FLIP (Human) cDNA Probe Description : Derived from the coding region of the human FLIP gene with a length of ~700bp located within the region between 1-700. Application: Detection of FLIP in several human tissues by Northern blot analysis. Human FLIP mRNA migrates as a 4.7kb, 3.9kb and 2.2kb. 1 μg F-1124 FLIP (NT) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 2-18 of human FLIP. Specificity: Recognizes short and long splice variants of human, mouse and rat FLIP. 100 μg F-1120 Fluo-3FF(AM) Description : Cell-permeable, acetoxymethyl ester (AM) derivative of Fluo-3FF. Has a very large fluorescent response upon Ca2+ binding. 500 μg F-1048 Fluo-3FF(K+ Salt) Description : A non-ratiometric dye which has a very large fluorescent response upon Ca2+ binding. 500 μg F-1050 Folate Receptor α Description : The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of ovarian carcinomas. 100 μl F-1128 Forskolin, Coleus forskohlii Description : A vasodilator and hypotensive agent. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. 10 mg F-1026 Fostriecin, Streptomyces Pulveraceous subsp. Fostreus Description : Anti-tumor antibiotic. Catalytic inhibitor of topoisomerase II. Strong inhibitor of protein phosphatase 2A, weak inhibitor of PP-1. 10 μg F-1038 Fraction I (FrI, Hela) Description : Protein fraction of cell extract that does not bind to anion exchange resin. Contains ubiquitin, FI E2s, and FI E3s. Ideal for demonstrating if FI enzymes are critical for degradation of in vitro substrates as well as in vitro conjugation activity. Source: Hela S3 cells. 1 mg U-1052 Fraction II (FII), Hela Description : Protein fraction of cell extract that binds to anion exchange resin. Essentially ubiquitin-free and ATP-free. Elute contains E1, most E2s, UCHs and the proteasome (20S and 26S). Source: Hela S3 cells. 1 mg U-1048 Fraction II, FII, Rabbit Reticulocyte Description : Protein fraction of cell extract that binds to an anion exchange resin. Essentially ubiquitin-free and ATP-free. Elate contains E1, most E2s, UCHs and the proteasome (20S and 26S). Source: Hela S3 cells. Ideal for demonstrating ubiquitin and/or ATP- dependent degradation of in vitro substrates as well as in vitro conjugation activity in the presence of proteasome inhibitor and isopeptidase inhibitor. 2.5 mg U-1044 Fumagillin, Aspergillus fumigatus Description : Inhibitor of endothelial cell proliferation and angiogenesis. 1 mg F-1028 Fumonisin B1, Fusarium moniliforme Description : Fungal metabolite, which inhibits spingomyelin biosynthesis in neuronal cells. 1 mg F-1022 Fumonisin B2, Fusarium moniliforme Description : Fungal metabolite with structure similar to Fumonisin B1, induces cancer. 5 mg F-1024 Fumonisin B3 Description : Recently purified metabolite. Please inquire for current availability and price. F-1049 Fura-2(AM) Description : Cell permeable Fluorescent Ca2+ indicator. Hydrolysis by non-specific esterases traps the indicator in the cytosol. 1 mg F-1040 Fura-2(K+ Salt) Product name : Fura-2(K+ Salt) 1 mg F-1042 Fura-2FF(AM) Description : Cell-permeable acetoxymethyl ester derivative of FURA-2FF with spectral properties similar to Fura-2FF. 500 μg F-1044 Fura-2FF(K+ Salt) Product name : Fura-2FF(K+ Salt) 500 μg F-1046 G-418.Sulfate Solid Description : Aminoglycoside used as a selective agent of transfected mammalian, yeast, plant and bacteria cells. Resistance is conferred by the bacterial gene for aminoglycoside-3'-phophotransferase that can be expressed in eukaryotic cells. Related to Gentamycin. 1 g G-1033 G-418.Sulfate, Sterile-Filtered Solution Description : Aminoglycoside used as a selective agent of transfected mammalian, yeast, plant and bacteria cells. Resistance is conferred by the bacterial gene for aminoglycoside-3'-phophotransferase that can be expressed in eukaryotic cells. Related to Gentamycin. Purity data is for a concentration of 50 mg/ml. 10 ml G-1035 Galanthamine.HBr Description : Inhibits acetylcholinesterase. 20 mg G-1187 GAP-43 Description : Axonal membrane phosphoprotein considered to be a plasticity or growth protein because it is highly expressed in neuronal growth cones during development and axonal elongation during regeneration. Application: ICC/IF (2.0 - 4.0 μg/ml), WB (0.5 – 2.0 μg/ml). Source: Rabbits were immunized with a synthetic peptide corresponding to amino acid residues 216-226 of rat and mouse GAP-43. 200 μl G-1214 GED.Bicarbonate Description : Potent inhibitor of mouse iNOS (NOS II) (EC50 = 30µM). Peroxynitrite scavenger. 10 mg G-1089 Geldanamycin, Streptomyces hygroscopicus Description : Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. 500 μg G-1047 Genistein Description : Inhibits Protein Tyrosine Kinases. Also inhibits other Protein Kinases by acting as a competitive inhibitor of ATP. 100 mg G-1015 Gentamycin Sulfate, Sterile-Filtered Solution, 10 mg / ml in DI Water Description : Sterile-Filtered, Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. It is useful for long-term virus and tissue culture studies. 10 ml G-1068-100 Gentamycin Sulfate, Sterile-Filtered Solution, 50 mg / ml in DI Water Description : Sterile-filtered, Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. It is useful for long-term virus and tissue culture studies. 10 ml G-1068-50 Gentamycin Sulfate, USP Grade Description : Broad spectrum, cell culture antibiotic that is non toxic to viruses and mammalian cells at antibacterial levels. It is useful for long-term virus and tissue culture studies. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. 1 g G-1067 Gephyrin Product name : Gephyrin G-1093 Geranylgeraniol Description : A potent inducer of apoptosis in numerous tumor cell lines. Also utilized for protein isoprenylation. 1 g G-1013 GF-109203X Description : Cell-permeable kinase inhibitor with a selectivity for Protein Kinase C (PKC). 1 mg G-1063 Glucose Dehydrogenase Product name : Glucose Dehydrogenase 100 KU G-1213 Glyburide Product name : Glyburide 5 g G-1185 Go 6976 Description : A very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes (α, β, y). Potent antagonist of HIV-1 induction. 500 μg G-1017 Gramicidin A (High Purity), Bacillus brevis Description : Naturally ocurring ion channel-forming pentadecapeptide antibiotic. Makes membranes permeable to protons and alkali metal ions, causes red blood cell lysis (at concentration 0.5-1.0ug/ml). Also causes non-voltage dependant K*/H* exchange in mitrochondri 25 mg G1215 Granzyme B (Human) (Purified) Description : One unit hydrolyzes 1nmole/min BAADT substrate. Using standard cell lines, 10µg is sufficient to kill 1x108 cells. 10 μg G-1025 Granzyme B Inhibitor (Fluoromethylketone) Description : Cell permeable and irreversible inhibitor of granzyme B. 1 mg G-1077 Granzyme B Inhibitor, Aldehyde Description : Reversible inhibitor of caspase-8 / caspase-3 processing enzyme and granzyme B. Inhibits also caspase-10. 1 mg G-1071 Granzyme B Inhibitor, Aldehyde Description : Inhibitor of granzyme B. Inhibits also caspase-6 and -10. This peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa25-28). It blocks the formation of p17 and induces the accumulation of p20. 1 mg G-1073 Granzyme B Substrate, Ac-IETD-AMC Description : Fluorogenic substrate for caspase-8 / caspase-3 processing enzyme and granzyme B. Also substrate for caspase-10. Peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). 1 mg G-1081 Granzyme B Substrate, Ac-IETD-pNA Description : Substrate for granzyme B. Peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). 1 mg G-1085 Granzyme B Substrate, BAADT Description : Chromogenic substrate for granzyme B. λ max is 405nm. 1 mg G-1079 Granzyme B Substrate, Z-IETD-pNA Description : Substrate for granzyme B with increased cell permeability. Peptide sequence corresponds to one of the cleavage sites of the inactive 32 kDa caspase-3 precursor (aa 172-175). 1 mg G-1083 Granzyme B, Human, B18.1 Description : Immunogen: Human recombinant granzyme B (aa 7-227). Specificity: To human granzyme B. Isopype: Mouse IgG1. Application: FC, ICC, IHC, (FS, PS), IP, WB. Purified 100 μg G-1059 Granzyme B, Human, GrB7 Description : Specificity: Recognizes human granzyme B. Does not cross-react with granzyme A. Concentration is 50 μg / ml. 1ml is sufficient for >200 tests. Isotype: Mouse IgG2a. Application: IHC (1:20, parrafin sections not recommended for frozen sections), WB. 50 μg G-1029 Granzyme B, Human, GrB7 Description : Clone: GrB7. Isotype: Mouse IgG2a. Specificity: 33 kDa human granzyme B. no cross-reactivity with granzyme A. Application: IHC (PS), WB. 50 μg G-1069 Granzyme B, Human, Purified Description : Activity: >10 units/ug. One unit hydrolyzes 1 nmole/min BAADT as substrate. Using standard cell lines, 10 μg is sufficient to kill 100 x 10 6 cells [2]. 10 μg G-1183 GSK3β Description : Antibody specific to the β form of GSK3β. GSK3β is involved in glycogen synthesis, microtubule assembly and possible Alzheimer's disease. Monoclonal to Glycogen Synththase Kinase 3β. Clone: 1H8. Isotype: IgG2a. 100 μg G-1011 Guanidine.HCl, Mole-Ready Description : 18 pouches per box, 57.3 g (0.6 mole) / pouch. A powerful protein denaturant that is widely used in purification of proteins, nucleic acids and mRNA. Mole-Ready form. Pre-weighed based on molar weight instead of grams in ready-to-use pouches. Stock solutions can be prepared without weighing. Ready-to-use. Prepare stock solution without weighing the dry product. Moisture proof pouches ensure high quality and ease of use. 1 box G-1219 Guanidine.HCl, Mole-Ready, Ultrapure Grade Description : 18 pouches per box, 57.3 g (0.6 mole) / pouch. A powerful protein denaturant that is widely used in purification of proteins, nucleic acids and mRNA. Also being used in DNA sequencing, molecular weight determinations, and solubilizing agent for electrophoresis. Ready-to-use. Prepare stock solution without weighing the dry product. 18 moisture proof pouches/box ensure high quality and ease of use 1 box G-1217 Guanidine.Thiocyanate, Mole-Ready Form, Molecular Biology Grade Description : 20 pouches per box, 47.3 g (0.4 mole) / pouch. Guanidine thiocyanate is a protein denaturant widely used in isolation of intact RNA. Mole-Ready form. Pre-weighed based on molar weight instead of grams in ready-to-use pouches. Stock solutions can be prepared without weighing. Ready-to-use. Prepare stock solution without weighing the dry product. Moisture proof pouches ensure high quality and ease of use. 1 box G-1215 HBTU Description : HBTU is an activation reagent used in solid phase and solution phase peptide synthesis. 500 g H-1118 HDAC Substrate (Fluorometric) Description : A fluorogenic substrate for histone deacetylase (HDAC). Ex(max): 330nm; Em(max): 395nm. 5 mg H-1178 HDAC1 Description : Source: Rabbit. Specificity: Recognizes human, mouse, rat, hamster and dog HDAC1. Detects a band of ~62kDa by Western Blot. Polyclonal Antibody to Histone Deacetylase 1 100 μg H-1162 HDAC11 (Human) (37D2492) Description : Isotype: Mouse IgM. Specificity: Recognizes human HDAC11. Monoclonal Antibody to HDAC11 (human) (37D2492) 200 μl H-1176 HDAC2 Description : Source: Rabbit. Specificity: Recognizes human, mouse, rat, hamster and dog HDAC2. Polyclonal Antibody to Histone Deacetylase 2 100 μg H-1164 HDAC3 Description : Source: Rabbit. Specificity: Recognizes human, rat, hamster and dog HDAC3. Detects a band of ~48kDa by Western Blot. Polyclonal Antibody to Histone Deactetylase 3 100 μg H-1166 HDAC4 (Human) (CT) Description : Source:Rabbit. Specificity: Recognizes human HDAC4. Polyclonal Antibody to Histone Deacetylase 4 (human) (CT) 100 μg H-1168 HDAC4 (NT) Description : Source: Rabbit. Specificity: Recognizes human and mouse HDAC4. Polyclonal Antibody to Histone Deacetylase 4 (NT) 100 μg H-1170 HDAC5 Description : Source: Rabbit. Specificity: Recognizes human and mouse HDAC5. Polyclonal Antibody to Histone Deacetylase 5 100 μg H-1172 HDAC6 Description : Source: Source: Rabbit. Specificity: Recognizes human and mouse HDAC6. Detects a band of ~134kDa by Western blot. Polyclonal Antibody to Histone Deacetylase 6 100 μg H-1174 Hellebrin, Helleborus sp. Description : Cardiotonic glycoside. Potent inhibitor of Na+, K+ -ATPase (sodium pump) blocking the active efflux of Na+ and reuptake of K+ of this membrane enzyme. 1 mg H-1160 Hemocyanin Subunits, Keyhole Limpet, Megathura crenulata, Liquid Description : Liquid, 20 mg/mL, in water, 0.22 μm Filtered. 50 mg H-1142 Hemocyanin Subunits, Keyhole Limpet, Megathura crenulata, Powder Description : Lyophilized powder, 10 mg, Sucrose excipient. 10 mg H-1144 Hemocyanin, Abalone, Haliotis tuberculata, Phosphate buffer Description : Liquid, 20 mg/mL, in Phosphate buffer. 20 mg H-1136 Hemocyanin, Abalone, Haliotis tuberculata, Phosphate Buffer, High Purity Description : Highly immunogenic. Bacterial Endotoxins: <12 EU/mg, 20 mg H-1128 Hemocyanin, Abalone, Haliotis tuberculata, subunits, lyophilized Description : Dry powder, 20 mg protein: Excipient: Sucrose. 20 mg H-1134 Hemocyanin, Horseshoe Crab, Limulus polyphemus, Ammonium sulphate Description : Liquid, 20 mg/mL slurry in 65% NH4SO4. 20 mg/mL H-1138 Hemocyanin, Horseshoe Crab, Limulus polyphemus, Phosphate Buffer, High Purity Description : Highly immunogenic. Bacterial Endotoxins: <12 EU/mg, 20 mg H-1130 Hemocyanin, Horseshoe Crab, Limulus polyphemus, subunits, lyophilized Description : Dry powder, 20 mg protein; Excipient Sucrose. H-1140 Hemocyanin, Keyhole Limpet, Megathura Crenulata, Ammonium Sulfate, High Purity Description : Protein Content 18-22 mg / ml, Copper/Protein Ratio 1.8 x 10-3 - 2.5 x 10-3, Bacterial Endotoxins: <11.7 USP-EU / mg. 25 mg H-1124 Hemocyanin, Keyhole Limpet, Megathura Crenulata, Phosphate Buffer, Bulk Liquid Description : Protein Content 20-30 mg / ml, Osmolarity 400-500 m Osmol / kg, Relative Density: 1.00-1.10, Bacterial Endotoxins: <11.7 USP-EU/mg. SDS PAGE: Band Near 370,000 Da 1 ml H-1126 HEPPS Description : Biological buffer with a useful pH range of 7.3-8.7. pKa=8.0 at 25°C. 1 kg H-1030 Herbimycin A, Streptomyces Hygroscopicus Description : A benzoquinoid ansamycin antibiotic that acts as a cell permeable inhibitor of tyrosine kinase and inducer of Heat Shock Proteins. Hsp90 inhibitor. Demonstrates anti-angiogenesis activity. 100 μg H-1050 HETE Product name : HETE 25 μg H-1098 Hexadecylphosphocholine (C16:0) Description : Alkylphosphocholine which acts as an anti-tumor agent. Also inhibits PKC. 250 mg H-1096 Histamine EIA (Qualitative Test) Description : The IDR qualitative histamine test kit is a simple screening system for histamine in fish, canned tuna, fishmeal and bonemeal. Histamine, 4-(2-amionoethyl)imidazole(MW=111), is a primary amine arising from the decarboxylation of the amino acid L-histidine. Therefore, histamine formed in foods is the result of the growth of bacteria that possess the enzyme histidine decarboxylase. Scombrotoxin poisonings have primarily been associated with the consumption of tuna, mahi mahi, and bluefish. The scombrotoxin formation that causes consumer illness in most closely linked to the development of histamine in these fish. 1 Kit H-1148 Histamine EIA (Quantitative Test) Product name : Histamine EIA (Quantitative Test) 1 Kit H-1146 HOBt Description : Inhibits racemization in peptide synthesis. 500 g H-1120 HONB Description : Decreases racemization in peptide synthesis. Also inhibits formation of N-acylureas. H-1122 HtrA2/Omi Description : Figure: Detection of endogenous HtrA2/Omi in human (HeLa) and mouse (Neuro2A) cells by Western blot (1:1'000). Transfected mouse and human HtrA2/Omi migrates at slightly higher molecular weight due to the HA-tag. 50 μl H-1180 Hydroxy-L-arginine.Monoacetate Description : Intermediate in the biosynthesis of nitric oxide from L-arginine. Alsoinhibits arginases. 5 mg H-1028 Hydroxycamptothecin Description : A DNA topoisomerase I inhibitor. It induces apoptosis in human breast cancer cells. 20 mg H-1132 Hydroxyecdysone Description : Most widely occurring ecdysteroid in both plant and animal species. 10 mg H-1094 Hydroxynonenal Description : Source: Rabbit. Immunogen: Free HNE coupled to KLH. Specificity: To visualize HNE-adducts. Application: WB, ELISA. ELISA (dilution 1:1000 to 1:10000), Immunohistochemistry (1:250-1000), Western Blot (dilution 1:250 to 1:1000). 100 μl H-1110 Hydroxynonenal Description : Among the aldehydes formed, HNE is the major product of lipid peroxidation, and it has been suggested to play a major role in liver toxicity associated with lipid peroxidation. 5 mg H-1112 Hydroxysaclofen Description : Selective antagonist of GABAB receptors, which demonstrates a higher selectivity than phaclofen. 10 mg H-1114 Hygromycin B, Concentrated Solution Description : An aminoglycosidic antibiotic. Used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. 1 mil. units H-1012-CON Hygromycin B, High Purity, in DI Water, Cell Culture Tested Description : Most popular form of Hygromycin B, the aminoglycosidic antibiotic used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. *(5 x 2 ml aliquots) 1 g H-1012-DI Hygromycin B, High Purity, in HEPES Buffer, Cell Culture Tested Description : Used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. * (10 x 2 ml aliquots) 1 g H-1012-HEPES Hygromycin B, High Purity, in PBS Buffer, Cell Culture Tested Description : Used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. * (10 x 2 ml aliquots) 1 g H-1012-PBS Hygromycin B, High Purity, Solid, Cell Culture Tested Description : An aminoglycosidic antibiotic. Used for the selection and maintenance of pro- and eukaryotic cells transfected with the E. coli hygromycin resistance gene. 500 mg H-1012-POWDER Hymenialdisine (see H1150) Description : Source: Isolated from sponge Axinella damicornis (Stylissa damicornis) [1]. H-1160 Hypericin, Hypericum perforatum Description : Antiviral which also inhibits Protein Kinase C and to a lesser extent Casein Kinase II and MAP Kinase. 1 mg H-1042 I1α Description : Affinity-purified antibody to I1αPP2A. Raised in rabbits to a synthetic peptide corresponding to residues 149-163 of the human kidney protein. Useful for Western blotting 100 μl I-1100 I1α detection kit Description : Same as Anti-I1α, except that, an I1αPP2A aliquot is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. Also effective for in situ immunofluorescence labeling. 1 Kit I-1102 I2α detection kit Description : Same as I1α PP2A, except that an aliquot of I2aPP2A is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit I-1096 I2α detection kit Description : Same as Anti-I2α, except that, an I2αPP2A aliquot is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. Also effective for in situ immunofluorescence labeling. 1 kit I-1106 IBMX Description : Inhibitor of phosphodiesterases. 500 mg I-1036 Ikarugamycin Description : Antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Inhibitor of clathrin-coated pits (CCP) dependent endocytosis 500 μg I-1192 Imino - 4 - Methylpiperidine.Acetate Salt Description : A potent and selective inhibitor of inducible Nitric Oxide Synthase, iNOS / NOS II (IC50= 0.1 mM). 25 mg I-1009 Indirubin-3’-monoxime Description : Selective and strong inhibitor of cyclin-dependent kinases. Inhibits the proliferation of a large range of cells, mainly through arresting the cells in the G2/M phase of the cell cycle. 1 mg I-1076 Indo-1FF(AM) Description : Cell-permeable acetoxymethyl ester derivative of Indo/1FF. 500 μg I-1084 Indo-1FF(K+ Salt) Description : A ratiometric dye which as a Ca2+ chelator and indicator of intracellular and extracellular Ca2+. Useful in flow cytometry. 500 μg I-1086 Ingenol Description : Protein Kinase C activator. Starting material for synthesis of ingenol derivatives. 1 mg I-1074 INHBP Description : Inhibitor of poly (ADP-ribose) Polymerase-1 (PARP-1). 1 mg I-1194 Inositol Product name : Inositol 25 g I-1058 Inositol Description : Natural occurring isomer of myo-inositol, product # I-1058. 5 mg I-1060 Ins (1,2,4,5)P4/PM Description : Slowly metabolizing and more potent calcium-elevating membrane-permeant myo-Inositol-1,4,5-trisphosphate analog than the AM-Ester. 1 μmol I-1210 Ins (1,2,5)P3/PM Description : Cell Permeable 1 μmol I-1238 Ins (1,2,5)P3/POM Description : Cell Permeable 1 vial I-1262 Ins (1,3,4)P3/AM Description : Membrane-permeant myo-Inositol-1,3,4-Trisphosphat derivative. Produced upon hormonal stimulation of cells. Immediate precursor is postulated to be myo-Inositol-1,3,4,5-Tetrakisphosphate. 2 μmol I-1220 Ins (1,3,4)P3/PM Description : More potent membrane-permeant myo-Inositol-1,3,4-Trisphosphat derivative than the AM-Ester. Produced upon hormonal stimulation of cells. Immediate precursor is postulated to be myo-Inositol-1,3,4,5-Tetrakisphosphate. 1 μmol I-1240 Ins (1,3,4)P3/POM Description : More potent membrane-permeant myo-Inositol-1,3,4-Trisphosphat derivative than the AM and PM-Ester. Produced upon hormonal stimulation of cells. Immediate precursor is postulated to be myo-Inositol-1,3,4,5-Tetrakisphosphate. 1 vial I-1264 Ins (1,3,4,5)P4/PM Product name : Ins (1,3,4,5)P4/PM 10 umol I-1204 Ins (1,3,4,5,)P4/AM Description : 10x1umol min order qty 10 umol I-1206 Ins (1,3,6)P3/AM Description : Membrane-permeant enantiomer of myo-Inositol-1,3,4-Trisphosphate derivative. Serves as control. 1 vial I-1222 Ins (1,3,6)P3/PM Description : More potent membrane-permeant myo-Inositol-1,3,6-Trisphosphate derivative than the AM-Ester. Serves as control. 1 μmol I-1242 Ins (1,3,6)P3/POM Description : More potent membrane-permeant myo-Inositol-1,3,6-Trisphosphat derivative than the AM- and PM-Ester. Serves as control. 1 vial I-1266 Ins (1,4,5)P3/AM Description : Cell Permeable 2 μmol I-1224 Ins (1,4,5)P3/PM Description : Cell Permeable 1 μmol I-1226 Ins (1,4,5)P3/PM Description : Cell Permeable 1 μmol I-1244 Ins (1,4,5)P3/POM Description : Cell Permeable 1 vial I-1268 Ins (1,4,6)P3/PM Description : Cell Permeable 1 μmol I-1208 Ins (1,4,6)P3/PM Description : Cell Permeable 1 μmol I-1246 Ins (1,4,6)P3/POM Description : Cell Permeable 1 vial I-1270 Ins (1,5,6)P3/AM Description : Cell Permeable 2 μmol I-1228 Ins (1,5,6)P3/PM Description : Cell Permeable 1 μmol I-1248 Ins (1,5,6)P3/POM Description : Cell Permeable 1 vial I-1272 Ins (2,3,5)P3/AM Description : Cell Permeable 2 μmol I-1230 Ins (2,3,5)P3/PM Description : Cell Permeable 1 μmol I-1250 Ins (2,3,5)P3/POM Description : Cell Permeable 1 vial I-1274 Ins (2,4,5)P3/AM Description : Cell Permeable 2 μmol I-1232 Ins (2,4,5)P3/PM Description : Cell Permeable 1 μmol I-1252 Ins (2,4,5)P3/POM Description : Cell Permeable 1 vial I-1276 Ins (2,5, 6)P3/POM Description : Cell Permeable 1 vial I-1278 Ins (2,5,6)P3/AM Description : Cell Permeable 2 μmol I-1234 Ins (2,5,6)P3/PM Description : Cell Permeable 1 μmol I-1254 Ins (3,4,5)P3/AM Description : Cell Permeable 2 μmol I-1236 Ins (3,4,5)P3/PM Description : Cell Permeable 1 μmol I-1256 Ins (3,4,5)P3/POM Description : Cell Permeable 1 vial I-1280 Ins (3,4,5,6)P4/PM Product name : Ins (3,4,5,6)P4/PM 1 μmol I-1202 Ins (3,4,6)P3/AM Product name : Ins (3,4,6)P3/AM 1 μmol I-1212 Ins (3,4,6)P3/PM Product name : Ins (3,4,6)P3/PM 1 μmol I-1214 Ins (3,4,6)P3/PM Description : Cell Permeable 1 μmol I-1258 Ins (3,4,6)P3/POM Description : Cell Permeable 1 vial I-1282 Ins (3,5,6)P3/AM Product name : Ins (3,5,6)P3/AM 2 μmol I-1218 Ins (3,5,6)P3/PM Product name : Ins (3,5,6)P3/PM 1 μmol I-1216 Ins (3,5,6)P3/PM Description : Duplicate of I-1216 I-1260 Ins (3,5,6)P3/POM Description : Cell Permeable 1 vial I-1284 Ins(1)P. 2K Product name : Ins(1)P. 2K 1 mg I-1042 Ins(1,2,3,4)P4 / AM Product name : Ins(1,2,3,4)P4 / AM 2 μmol I-1288 Ins(1,2,3,4)P4 / PM Product name : Ins(1,2,3,4)P4 / PM 1 μmol I-1158 Ins(1,2,3,4)P4 / POM Product name : Ins(1,2,3,4)P4 / POM 1 vial I-1132 Ins(1,2,3,4)P4.4K Product name : Ins(1,2,3,4)P4.4K 100 μg I-1068 Ins(1,2,3,4,5)P5 Product name : Ins(1,2,3,4,5)P5 100 μg P-1353 Ins(1,2,3,4,5,6)P6 Description : Inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Major phosphorus compound in plants. *Purity: Homogeneous by TLC. 25 mg I-1286 Ins(1,2,3,4,6)P5 Product name : Ins(1,2,3,4,6)P5 100 μg P-1355 Ins(1,2,3,5)P4 / AM Product name : Ins(1,2,3,5)P4 / AM 2 μmol I-1290 Ins(1,2,3,5)P4 / PM Product name : Ins(1,2,3,5)P4 / PM 1 μmol I-1162 Ins(1,2,3,5)P4 / POM Product name : Ins(1,2,3,5)P4 / POM 1 vial I-1134 Ins(1,2,3,5)P4. 4K Product name : Ins(1,2,3,5)P4. 4K 100 μg I-1052 Ins(1,2,3,5,6)P5 Product name : Ins(1,2,3,5,6)P5 100 μg P-1357 Ins(1,2,3,6)P4 Product name : Ins(1,2,3,6)P4 100 μg I-1070 Ins(1,2,3,6)P4 / AM Product name : Ins(1,2,3,6)P4 / AM 2 μmol I-1292 Ins(1,2,3,6)P4 / PM Product name : Ins(1,2,3,6)P4 / PM 1 μmol I-1112 Ins(1,2,3,6)P4 / POM Product name : Ins(1,2,3,6)P4 / POM 1 vial I-1136 Ins(1,2,4,5)P4 Product name : Ins(1,2,4,5)P4 100 μg P-1343 Ins(1,2,4,5)P4 / PM Product name : Ins(1,2,4,5)P4 / PM 1 μmol I-1114 Ins(1,2,4,5)P4 / POM Product name : Ins(1,2,4,5)P4 / POM 1 vial I-1138 Ins(1,2,4,5,6)P5 Product name : Ins(1,2,4,5,6)P5 100 μg P-1359 Ins(1,2,5)P3 Product name : Ins(1,2,5)P3 100 μg P-1363 Ins(1,2,5,6)P4 Product name : Ins(1,2,5,6)P4 100 μg P-1109 Ins(1,2,5,6)P4 Product name : Ins(1,2,5,6)P4 100 μg P-1345 Ins(1,2,5,6)P4 / AM Product name : Ins(1,2,5,6)P4 / AM 2 μmol I-1152 Ins(1,2,5,6)P4 / PM Product name : Ins(1,2,5,6)P4 / PM 1 μmol I-1116 Ins(1,2,5,6)P4 / POM Product name : Ins(1,2,5,6)P4 / POM 1 vial I-1140 Ins(1,3)P2 Product name : Ins(1,3)P2 500 μg I-1082 Ins(1,3,4)P3 Description : Produced upon hormonal stimulation of cells. 100 μg D-1023 Ins(1,3,4,5)P4 / PM Product name : Ins(1,3,4,5)P4 / PM 1 μmol I-1118 Ins(1,3,4,5)P4 / POM Product name : Ins(1,3,4,5)P4 / POM 1 vial I-1160 Ins(1,3,4,5)P4, K+ Description : Suggested to play a second-messenger role different from that of Ins(1,4,5)P3. 500 μg D-1025 Ins(1,3,4,5)P4, NH4+ Product name : Ins(1,3,4,5)P4, NH4+ 500 μg P-1371 Ins(1,3,4,5,6)P5 Product name : Ins(1,3,4,5,6)P5 100 μg I-1054 Ins(1,3,4,6)P4 Product name : Ins(1,3,4,6)P4 100 μg P-1113 Ins(1,3,4,6)P4 / AM Product name : Ins(1,3,4,6)P4 / AM 2 μmol I-1097 Ins(1,3,4,6)P4 / PM Product name : Ins(1,3,4,6)P4 / PM 1 μmol I-1120 Ins(1,3,4,6)P4 / POM Product name : Ins(1,3,4,6)P4 / POM 1 vial I-1142 Ins(1,3,5,6)P4 / AM Product name : Ins(1,3,5,6)P4 / AM 2 μmol I-1154 Ins(1,3,5,6)P4 / PM ] Product name : Ins(1,3,5,6)P4 / PM ] 1 μmol I-1122 Ins(1,3,5,6)P4 / POM Product name : Ins(1,3,5,6)P4 / POM 1 vial I-1144 Ins(1,3,5,6)P4.4K Product name : Ins(1,3,5,6)P4.4K 100 μg I-1050 Ins(1,3,6)P3 Product name : Ins(1,3,6)P3 100 μg P-1373 Ins(1,3,6)P3.3Na Description : Enantiomer of myo-Inositol-1,3,4-trisphosphate. Serves as control. 100 μg P-1365 Ins(1,4)P2 Product name : Ins(1,4)P2 500 ug I-1196 Ins(1,4,5) P3, P4(5)-1-(2-nitrophenyl) ethyl Ester, Sodium salt Description : Photolabile derivate of Ins(1,4,5)P3 that is not biologically active and is not metabolized by endogenous phosphatase. A short pulse of light (254 or 360 nm) releases biologically active Ins(1,4,5)P3 within a second. 1 mg I-1200 Ins(1,4,5)P3 Description : Causes release of calcium from intracellular stores. 1 mg D-1021 Ins(1,4,5)P3.3 Li Description : Causes release of calcium from intracellular stores. Trilithium Salt Form. 1 mg D-1097 Ins(1,4,5)P3.3NH3 Description : Causes release of calcium from intracellular stores. Ammonium Salt Form. 1 mg D-1101 Ins(1,4,5)P3.6 Na Description : Causes release of calcium from intracellular stores. Sodium Salt Form. 1 mg D-1099 Ins(1,4,5)P3.6K Description : Inactive negative control for D-myo-Inositol 1,4,5-trisphosphate 1 mg I-1038 Ins(1,4,5,6)P4 / AM Product name : Ins(1,4,5,6)P4 / AM 2 μmol I-1168 Ins(1,4,5,6)P4 / PM Product name : Ins(1,4,5,6)P4 / PM 1 μmol I-1124 Ins(1,4,5,6)P4 / POM Product name : Ins(1,4,5,6)P4 / POM 1 vial I-1146 Ins(1,4,5,6)P4, K+ Product name : Ins(1,4,5,6)P4, K+ 100 μg P-1107 Ins(1,4,5,6)P4, NH4+ Product name : Ins(1,4,5,6)P4, NH4+ 100 μg P-1347 Ins(1,4,6)P3 Product name : Ins(1,4,6)P3 100 μg I-1048 Ins(1,5)P2, K+ Product name : Ins(1,5)P2, K+ 100 μg I-1044 Ins(1,5)P2, Na+ Product name : Ins(1,5)P2, Na+ 100 μg I-1046 Ins(1,5,6)P3 Product name : Ins(1,5,6)P3 100 μg P-1105 Ins(2,3,4,5)P4 Product name : Ins(2,3,4,5)P4 100 μg P-1349 Ins(2,3,4,5)P4 / AM Product name : Ins(2,3,4,5)P4 / AM 2 μmol I-1156 Ins(2,3,4,5)P4 / PM Product name : Ins(2,3,4,5)P4 / PM 1 μmol I-1126 Ins(2,3,4,5)P4 / POM Product name : Ins(2,3,4,5)P4 / POM 1 vial I-1148 Ins(2,3,4,5,6)P5 Product name : Ins(2,3,4,5,6)P5 100 μg P-1361 Ins(2,3,5)P3.3K Product name : Ins(2,3,5)P3.3K 100 μg I-1049 Ins(2,3,5,6)P4 / AM Product name : Ins(2,3,5,6)P4 / AM 2 μmol I-1166 Ins(2,3,5,6)P4 / PM Product name : Ins(2,3,5,6)P4 / PM 1 μmol I-1128 Ins(2,3,5,6)P4 / POM Product name : Ins(2,3,5,6)P4 / POM 1 vial I-1150 Ins(2,4,5)P3 Product name : Ins(2,4,5)P3 100 μg P-1367 Ins(2,5,6)P3 Product name : Ins(2,5,6)P3 100 μg P-1369 Ins(3,4,5)P3 Product name : Ins(3,4,5)P3 100 μg I-1066 Ins(3,4,5,6)P4 Product name : Ins(3,4,5,6)P4 100 μg P-1111 Ins(3,4,5,6)P4 / AM Product name : Ins(3,4,5,6)P4 / AM 2 μmol I-1164 Ins(3,4,5,6)P4 / PM Product name : Ins(3,4,5,6)P4 / PM 1 μmol I-1130 Ins(3,4,6)P3 Product name : Ins(3,4,6)P3 100 μg P-1339 Ins(3,5,6)P3 Product name : Ins(3,5,6)P3 100 μg P-1341 Ins(4,5)P2 Product name : Ins(4,5)P2 500 mg I-1198 Interleukin-17E (Human)(68C1039) Description : Immunogen: Synthetic peptide derived from human IL-17E. Specificity: Recognizes human and mouse IL-17E. Detects a 16kDa by Western Blot (2ug/ml). Positive Control: Mouse testies tissue can be used for positive control. Clone: 68C1039. Isotype: Mouse IgG1. 100 μg I-1190 Iodotubercidin, Itu Description : A potent and specific inhibitor of ERK2. Also adenosine kinase inhibitor. 5 mg I-1005 Ionomycin, Free Acid, Streptomyces conglobatus Description : Highly specific ionophore useful in studying Ca2+ transportation. 1 mg I-1014 IRS-1 (Y608) Peptide Description : The tyrosine phosphorylated version of this peptide binds to phosphatidylinositol 3-kinase SH2 domain and activates the enzyme. 1 mg I-1062 Isovelleral Description : Antagonist with various binding profiles towards vanilloid receptors. 1 mg I-1034 JC-1.chloride Description : JC-1 is a very sensitive fluorescent probe to test Pgp activity. In acute myeloid leukemia (AML) samples JC-1 is capable of distinguishing between resistant, intermediate and sensitve groups. 5 mg J-1092 JC-1.Iodide Description : JC-1 stains mitochondria in living cells in a membrane potential-dependent function. JC-1 has been used in a functional assay of multidrug resistance cells and in apoptosis related mitochondrial modifications. 5 mg J-1090 Jervine Description : Steroidal alkaloid that specifically disrupts the Sonic hedgehog (Shh) signaling pathway. Certain cancers induce abnormal expression of the hedgehog pathway as a means of providing tumors with certain factors that support tumor growth. 1 mg J-1098 JM34 Description : A pyridinylamide inhibitor of TNF-α. Does not inhibit PKC activity in vitro. An excellent alternative to classical COX inhibitors in TNF-α involved pathogenesis. 10 mg J-1006 JM42 Description : A pyridinylamide inhibitor of TNF-α. Most likely through a PKC dependent pathway. 5 mg J-1004 JS-2190 Description : Inhibitor of P-glycoprotein (Pgp) and MRP1. 5 mg J-1094 K-252a, Nocardiopsis sp. Description : A general protein kinase inhibitor. CaM (Ki=1.8 nM), PKA (Ki=25 nM), PKC (Ki=25 nM), PKG (Ki=20 nM), myosin light chain kinase (Ki=17 nM). 100 μg K-1006 K-252b, Nocardiopsis sp. Description : A general protein kinase inhibitor. 100 μg K-1008 K-252c Description : PKC inhibitor. K-1070 Kainic Acid Description : Excitatory amino acid receptor agonist selective for kainate receptor subtype; conformationally restricted analog of L-glutamic acid. 10 mg K-1012 Kanamycin Sulfate, Streptomyces kanamyceticus Description : Aminoglycosidic antibiotic which inhibits growth of gm-positive, gm-negative bacteria and mycoplasmas in cell culture. 10 g K-1022 Kasugamycin . Hydrochloride Description : Unique aminogylcoside antibiotic with less potential to create cross-resistant human pathogens compared to other aminoglycoside antibiotics [1]. 1 g K-1066 Kendomycin, Streptomyces violaceoruber Description : Potent endothelin receptor antagonist. Antiosteoporotic compound. Shows remarkable antibacterial and cytotoxic activity. 100 μg K-1048 Kenpaullone Description : Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50=0.4uM) also inhibits CDK2/cyclin A (IC50=0.68 μm). Weaker effect on other kinases. 1 mg K-1050 Ketanserin Tartrate Description : Selective 5-HT2 & 5-HT1C serotonin receptor antagonist. 50 mg K-1044 Ketorolac.Tromethamine Salt Description : A Non-steroidal anti-inflammatory drug (NSAID). Inhibits Prostaglandin H Synthase. Also shown to affect NMDA receptor activity. 1 g K-1046 Keyhole Limpet, Megathura crenulata Description : Source of Keyhole-Limpet Hemocyanin (KLH). 1 each K-1002 Kinesin Protein 2, (KIF2), Purified Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to the N-terminal aa residues 1-11 (M1VTSLNEDNES11) of human and mouse KIF2 with a C-terminal cysteine added for conjugation to KLH. Specificity: Detects a ~95kDa protein in extracts from wild-type mice but not KIF2 knockout mice. Application: WB. 200 μl K-1054 KN-62 Description : Selective inhibitor of CaM kinase II (Ki=900 nM). 1 mg K-1004 KN-93 Description : Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Induces G1 cell cycle arrest and apoptosis. 1 mg K-1060 KT-5720 Description : A potent and selective inhibitor of Protein Kinase A (Ki=56 nM). 100 μg K-1010 KT-5823 Description : A highly specific inhibitor of protein kinase g (PKG). 100 ug K-1040 Kuanoniamine C Description : Isolated from the sponge Oceanapia spec. Inhibits proliferation of HCT, HeLa (IC50=5.1 μg/ml), and MOMO-MAC 6 (IC50=1.2 mg/ml) cell lines. Binds to adenosine receptor subtypes A1 and A2A. 1 mg K-1052 Lactacystin Description : Cell permeable, irreversible proteasome inhibitor. Specifically inhibits the 20S and 26S proteasome. Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. 100 μg L-1147 Lactacystin β-lactone, Synthetic Description : Synthetic. Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. It is believed lactacystin acts as a precursor for clasto-lactacystin b-lactone.. 200 μg L-1055 Lactamase Description : Beta-Lactamase, E.C.3.5.2.6, penicillin amido-beta-lactam hydrolase, isolated from the organism, Bacillus cereus 569/H9 Bacterial enzyme that destroys beta-lactam antibiotics. Broad sprectrum of activity against both penicillins (penicillinase or Beta I activity) and cephalosporins (cephalosporinase or Beta II activity). BETA-LACTAMASE will inactivate the following antibiotics: Beta-Lactam: Benzylpenicillin, ampicillin, amoxycillin, carbenicillin, methicillin, cloxacillin, flucloxacillin. Cephalosporins: cephaloridine, cephalothin, cephalexin, cephazolin, cephradine*,cefuroxime*, cefoxitin*, ceftizoxime*, cefpiramide* (*require longer incubations for total inactivation).Carbapenems: Bacillus cereus Beta-Lactamse II has been reported to hydrolyse some carbapenems.Sterilty: The vialed products are bacteriologically sterile. They are sterilized by gamma irradiation. No detectable growth in Nutrient Broth at 37 °C for fourteen days 1 Vial L-1163 Laminin-2, α2-chain Description : Specificity: Recognizes the mouse laminin-2 (α2-chain); cross reacts with the human protein. No cross-reaction with laminin-1. Clone: 4H8-2. Isotype: Rat IgG1. Application: ELISA, IP, ICC; not WB. Reacts with the intact laminin α2-polypeptide and recognizes an N-Terminal portion of the chain. The only tool available for identification of CMD that results from N-terminal deletions of the laminin α2-chain. 100 μg L-1051 Latrunculin B, Lutrunculia magnifica Description : Actin filament modulator. 10 to 100-fold more potent than cytochalasins. Whereas cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, latrunculin B causes a shortening and thickening of stress fibers. 1 mg L-1057 Leinamycin Description : Antitumor antibiotic. L-1149 Leptin Description : Source: Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 25-44 (Q25KVQDDTKTLIKTIVTRIND44) of mouse leptin. Specificity: Recognizes human, mouse, rat and sheep leptin. 50 μl L-1151 Leptin (Human) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 91-106 (S91RNVIQISNDLENLRD106) of human leptin. Specificity: Recognizes human leptin. Application: Western blot (dilution 1:1000). 100 μl L-1155 Leptin (Human) (Recombinant) Description : Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. *Merck Index: (Antimycin A1) & 721 (Antimycin A3) 100 μg L-1153 Leptin (Human) ELISA Kit Description : Sensitivity: 0.5ng/ml. Quantity: 96 wells. Kit/Set Contains: Includes instructions and reagents (anti-leptin, horseradish peroxidase conjugate, human leptin standards, buffers, substrate solution, quality control). 1 Kit L-1159 Leptin Receptor Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 577-594 (K577EIQWKTHEVFDAKSKSA594) of the extracellular domain of rat leptin receptor (OB-R). 100 μl L-1157 Leptin Receptor (Human) ELISA Kit Description : Sensitivity: 0.4U/ml. Quantity: 96 wells. Specificity: Human leptin receptor. Application: Quantitative measurement of human leptin receptor in serum, plasma and tissue culture medium. 1 Kit L-1161 Leptomycin B, Streptomyces sp. ATS1287 Description : Antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathway. It also demonstrates anti-fungal & anti-tumor activity. 1 μg L-1069 Leukotriene B4 Description : Activator of PPARa. Stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 25 μg L-1047 Lidocaine EIA Description : The enzyme immunoassay for lidocaine is based on the competition between the lidocaine to be assayed and the Lidocine-enzyme conjugate, for binding to antibody directed against the lidocaine, coated onto microtiter wells. The intesity of the color developed is inversely proportional to the concentration of lodocaine in the sample. Therefore, those samples that contain the lidocaine will inhibit binding of the enzyme conjugate to the capture antibody resulting in less color than the negative control. The concentration is estimated by comparison with standard lidocaine solution. 1 Kit L-1061 Linamarin Description : A cyanogenic glycoside. 250 mg L-1045 Lipoma Preferred Partner Description : Source: Rabbit. Immunogen: Recombinant human lipoma preferred partner (LPP) (aa 1-109). Specificity: Raised against a recombinant fusion protein comprising residues 1-109 of human LPP. Recognizes human, porcine and rat LPP. Application: WB, IP, ICC. Includes positive control 100 μg of human skin fibroblast protein. 50 μl L-1053 Lovastatin Description : Inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Also inhibits MAP kinase and p21ras activation. 25 mg L-1043 LY-171833 Description : Competitive leukotriene D4 antagonist. Has also been shown to bind to the γ-isoform of the peroxisome proliferator activator receptor (PPARγ), inducing adipogenesis in cultured NIH 3T3 fibroblasts. 10 mg L-1049 LY-294002 Description : A potent and specific, cell permeable inhibitor of phosphatidylinositol 3-kinase (PI3-Kinase). 5 mg L-1023 LY-333531 Description : Potent, selective inhibitor of Protein Kinase C isozymes, PKC β I(IC50=4.7 nM) and PKC β II (IC50=5.9 nM). 1 mg L-1011 LY-83583 Description : An inhibitor of soluble guanylate cyclase. Inhibits nitric oxide induced smooth muscle relaxation. 5 mg L-1013 Lyngbyatoxin A Description : Marine Toxin isolated from blue-green alga Lyngbya majuscula. Potential PKC activator. L-1141 M344 Description : Potent inhibitor of histone deacetylase (HDAC) (IC50£1µM). 1 mg M-1203 MAHMA-NONOate Description : A Nitric Oxide Donor, useful for the reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half life (t1/2) for NO release at 37°C is 1-2 minutes. 25 mg M-1030 Makisterone A Description : A member of the ecdysteroid family, which are involved in basic invertebrates functions, such as molting, metamorphosis, reproduction, metabolism and excretion. 1 mg M-1080 Manoalide, Luffariella variabilis Description : Irreversible inhibitor of phospholipase A2. Also inhibits phospholipase C and Ca2+ channels. 100 μg M-1103 Manumycin A, Streptomyces parvulus Description : A potent and selective inhibitor of Ras farnesyltransferase. 1 mg M-1052 MAPI, Synthetic Description : HIV Protease inhibitor. Binds strongly to the active site of HIV protease. 1 mg M-1110 MAZ51 Description : Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt4) (IC50=1uM) 2 mg M-1191 MC 1293 Description : Inhibitor of histone deacetylase 1 (HDAC1) (IC50=4.5uM) [2] and maize histone deacetylase HD2 (IC50=1.9uM) [1]. 5 mg M-1189 Mca - Arg - Pro - Lys - Pro - Try - Ala - Nva - Trp - Met - Lys(Dnp) -NH2 Description : Fluorogenic substrate for MMP-1, MMP-2, MMP-3 and MMP-9. M-1165 Mca - Arg - Pro - Lys - Pro - Val - Glu - Nva - Trp - Arg - Lys(Dnp) - NH2 Description : Fluorogenic substrate for MMP-3 and MMP-9. 1 mg M-1159 Mca - Pro - Cha - Gly - Nva - His - Ala - Dap(Dnp) - OH Description : Fluorogenic substrate for MMP-13. 1 mg M-1161 Mca - Pro - Leu - Ala - Nva - Dap(Dnp) - Ala - Arg - NH2 Description : Fluorogenic substrate for MMP-2. 1 mg M-1163 Mca - Pro - Leu - Gly - Leu - Dap (Dnp) - Ala - Arg - NH2 Description : Fluorogenic substrate for MMP-2 and MMP-7. 1 mg M-1167 MCAD Description : Source: Rabbit. 100 ul of lyophilized antiserum. Immunogen: Purified human recombinant MCAD. Recombinant human medium-chain fatty acyl-CoA dehydrogenase (MCAD).Specificity: Detects human, porcine, ovine and mouse MCAD. Application: WB. 1 vial M-1112 MDL-105212.HCl Description : Non-peptide tachykinin antagonist with strong affinity for NK1 and NK2 receptors. 1mg M-1092 MEDICA 16 Description : Inhibitor of lipid synthesis. 5 mg M-1114 MEG Description : A specific, inducible Nitric Oxide Synthase (iNOS) inhibitor and a scavenger of peroxynitrite. 10 mg M-1042 Melatonin Description : Neurohormone which controls photo-periodic biological rhythms. 1 g M-1040 Meloxicam Description : Anti-inflammatory. COX-2 inhibitor. 1 kg M-1169 Memantine.Hydrochloride Description : Antagonist of NMDA receptors. Stimulates dopamine release. Antiparkinsonian, antispasmodic. Also shown to slow cognitive decline in patients with advanced Alzheimer's disease. 100 mg M-1024 Methyl - L - thiocitrulline.Dihydrochloride Description : A potent, selective inhibitor of neuronal Nitric Oxide Synthase. 10 mg M-1012 Methylcytidine Product name : Methylcytidine 1 g M-1106 Methylglutamic Acid Description : Selective ligand for the kainate receptor. 5 mg M-1100 Methylguanine-DNA methyltransferase Description : Source: Rabbit. Immunogen: Raised against complete O6-methylguanine-DNA methyltransferase of human origin. Specificity: Recognizes human MGMT Application: WB (1:100-1:1000). 100 μl O-1080 Mevastatin Description : Antibiotic which acts as a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis 50 mg M-1102 MG-115 Description : Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. 1 mg M-1155 MG-132 Description : Potent, reversible and cell permeable proteasome inhibitor. Inhibits NF-κB activation. 1 mg M-1157 MGMT (Human) (Recombinant) Description : Host: Human recombinant MGMT produced in E. coli. Purified with Glutathiose-Sepharose 4B and thrombin cleavage. Specific Activity: 100 units/µl. 1 unit removes 100fmol O6-methylguanine from DNA. 50 μl M-1201 Mitomycin C, Streptomyces caespitosus Description : Inhibitor of DNA synthesis, nuclear division. Induces apoptosis in cancer cells. Does not melt below 360°C. 5 mg M-1108 MK-571.Na Description : Leukotriene LTD4 receptor antagonist, that potently inhibits MRP1, has been shown to overcome acquired arsenic tolerance. 5 mg M-1177 MMP-2/MMP-9 Inhibitor Description : Potent and selective inhibitor of matrix metalloproteinases 2 and 9. 5 mg M-1193 MnTBAP Description : Cell permeable SOD mimetic. Also a peroxynitrite scavenger but not a Nitric Oxide NO scavenger. 50 mg M-1018 MnTMPyP Description : Cell permeable SOD mimetic. Catalyzes the dismutation of O2- even in the presence of excess EDTA. 50 mg M-1020 Monastrol Description : Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50 = 14µM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity. 1 mg M-1116 Monensin EIA Description : The antibiotic monensin (MW=670.9) is a carboxylic acid ionophore (polyether ionophore) which has important applications in the veterinary field. The Monensin EIA kit is a rapid and simple detection system for monensin in feed extract. FDA of the United States has set the guidelines for the allowable level of monensin in animal feed, and the specific tolerance for monensin in edible product of animals. Crossreactivity: By the assay, the following compounds tested at the stated levels are found to give results not greater than a level of 2.5 μg/ml of monensin. 1 Kit M-1183 Monensin Methyl Ester Description : Use in preparatioin of ion-selective membranes for ion-selective electrodes. 100 mg M-1213 Monensin, Sodium Salt (High Purity) Description : Functions as Na+ ionophore by forming stable complexes with monovalent cations able to cross the plasma membrane. Blocks glycoprotein secretion; inhibits HDL to decrease cellular cholesterol esterification. 250 mg M-1211 MOPS Description : A zwitterionic buffer active in the pH range of 6.5 to 8.0. 100 kg @ $100 / kg, 250 kg @ $95 / kg. 100 kg M-1032 MRP1 (Human) (QCRL-4) Description : Specificity: Recognizes human MRP1. Does not cross-react with human Pgp and MDR3 Pgp. Application: ICC, IP, FUNC - inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles. Not recommended for WB. Clone: QCRL-4. Isotype: Mouse IgG1. Immunogen: Non-denatured membranes from the human small cell lung cancer cell line H69AR, which highly overexpresses MRP1. 1 ml M-1175 MRP1 (Human)(QCRL-2) Description : Immunogen: Non-denatured membranes from the human samll cell lung cancer cell ling H69AR, which highly overexpresses MRP1. Specificity: Recognizes human MRP1. Clone: QCRL-2: Does not cross-react with human Pgp and MDR3 Pgp. Inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles. Isotype: Mouse IgG2b. Application: ICC, IP, RUNC. Not recommended for WB. 1ml M-1173 Mucosal Addressin Cell Adhesion Molecule (EpCAM)(Human) Description : Specificity: Reacts with human MAdCAM-1. Clone: CA 102.2C1. Isotype: Mouse IgG1. Application: ELISA, WB, FUNC, (blocks the binding of human α-4β7 expressing cells to immobilized human MAdCAM-1 in cellular assays. 100 μg M-1179 Muristerone A Description : Muristerone A regulates the metamorphosis of Drosophila melanogaster and is used to induce expression of the gene of interest from any of the ecdysone-inducible system expression vectors. 500 μg M-1060 Muscimol Description : GABAA receptor agonist. (Inquire for HBr formulation). See M-1057 for HBr formulation. 5 mg M-1056 Muscimol.HBr Description : GABAA receptor agonist. Reported to abolish 3H-GABA binding to GABAa receptor (k1=105nM). See M-1056 for non-HBr formulation 5 mg M-1057 Mycalolide B Description : Isolated from the marine sponge Mycale sp. Inhibits actin polymerization. Depolymerizes F-actin by nibbling and forms a 1:1 complex with G-actin 100 μg M-1171 Mycophenolic Acid Description : Immunosuppressive agent. Mycophenolic acid (MPA) has been tested extensively in renal transplant patients and has been shown to be effective in reducing the incidence of acute graft rejection. MPA is now being evaluated in combinations with tacrolimus (FK-506, Prod# F-1030) or sirolimus (Rapamycin, Prod# R-1018). It selectively inhibits lymphocyte proliferation by blocking the enzyme, inosine monophosphate dehydrogenase, part of in the guanosine monophosphate pathway. This enzyme is involved in the de novo synthesis of purine nucleotides1. 250 mg M-1036 Myelin Basic Protein Kinase Assay Kit Description : Useful for determining the activity of cPK or related protein serine/threonine kinase. Can be used to evaluate the effect of a test substance on cPK activity or to identify potential new physiological substrates of the enzyme. Assay is based on the reaction of kinase sample with MBP and [γ-32P]ATP. Kit includes directional insert, and contains solutions of MgATP, MBP, assay and dilution buffer, and purified MBPK-1 sample 1 Kit M-1181 N-Smase Spiroepoxide Inhibitor Description : Irreversible and selective inhibitor of neutral sphingomyelinase [1,2] 1 mg N-1121 NBQX Description : Potent and selective AMPA/Kainate receptor antagonist. Neuroprotective agent. 5 mg N-1019 NBQX.diSodium Salt Description : Potent and selective AMPA/Kainate receptor antagonist. Neuroprotective agent. Water soluble. 5mg N-1019-2Na NDSB-195, (Non-Detergent Sulphoβines) Description : Efficiently solubilizes proteins at non-denaturing concentrations. Useful in the isolation and purification of proteins, protein crystallization and renaturation of proteins. 5 g D-1089 NDSB-201 Product name : NDSB-201 25 g D-1119 NDSB-211, (Non-Detergent Sulphoβines) Description : Efficiently solubilizes proteins at non-denaturing concentrations. Useful in the isolation and purification of proteins, protein crystallization and renaturation of proteins. 5 g D-1091 NDSB-256 Product name : NDSB-256 5 gm D-1121 NEDD8 Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 20.32 of human NEDD8. Specificity: Recognizes human, mouse and rat NEDD8. Does not cross react with ubiquitin or SUMO-1/sentrin-1. Formulation: Contains 1mm sodium azide. Application: WB, ICC. 200 μl S-1090 Neomycin Sulfate Description : An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Also has high binding affinity to phosphatidylinositol 4,5-bisphosphate (PIP2). 25 g N-1053 Netropsin . Dihydrochloride Description : Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA. 5 mg N-1159 Neurofibromin Description : Source: Rabbits were immunized with a synthetic peptide based on amino acid residues 27-41 of human neurofibromin. Cross-Reactivity: Mam. Application: ICC/IF (1/100 – 1/500), WB (1/250 – 1/1,000). Neurofibromin is a tumor suppressor with GTPase activity that modulates the ras pathway. 0.2 ml N-1167 Neurturin Description : Neurturin is a member of the GDNF (glial cell-derived neurotrophic factor) family ligands (GFLs) which includes GDNF, artemin, neurturin, and persephin. They act as survival factors for autonomic, sensory, central motor and dopaminergic neurons. Source: Rabbits were immunized with a synthetic peptide sequence based on amino acids 178-193 of human neurturin protein. Cross-Reactivity: Human. Application: WB (1/500 – 1/1,000). 0.2 ml N-1169 Nidulal Description : Induces differentiation of human promyelocytic leukemia cells. In COS-7 cells nidulal selectively activates AP-1 dependent signal transduction in a mannner similar to TPA. 0.5 mg N-1161 Nigericin Description : Polyether ionophore. Stimulates ATPase activity in mitochondria. 5 mg N-1103 NIL Description : Selective inhibitor of inducible nitric oxide synthase (iNOS, NOS II). D-1117 NIL.HCl Description : A selective inhibitor of inducible Nitric Oxide Synthase (iNOS). 10 mg I-1001 Nimesulide Description : Specific inhibitor of COX-2 50 g N-1081 Nimodipine Description : L-type Ca2+ channel agonist. Vasodilator. 250 mg N-1073 NIO.2HCl Description : A potent inhibitor of endothelial Nitric Oxide Synthase (eNOS). 25 mg I-1003 Nitro-Tyrosine Kit Description : Nitro-tyrosine (NT) has been used extensively as an index of peroxynitrite formation. This kit allows researchers to assay NT in various bio-fluids, using a powerful novel HPLC assay. Produced by OXONON. This kit is good for 50 samples. When stored at 4°C, the kit can be stored for up to one year. We do recommend, for optimum performance, that the nitrotyrosine standard (Vial 4) is kept frozen. 1 Kit N-1099 Nitroindazole Description : An inhibitor of Nitric Oxide Synthase (NOS). It has a selectivity for brain NOS. 100 mg N-1011 Nitroindazole.Monosodium Salt Description : A readily soluble inhibitor of Nitric Oxide Synthase (NOS). It has a selectivity for brain NOS. 25 mg N-1013 Nitroso-Thiol Kit, Colorometric Description : The assay of nitrosothiols (RSNOs) provides an index of nitric oxide synthase (NOS) activity. The concentration of RSNOs has been shown to increase with localized induction of NOS. This kit provides a complete solution for the assay of RSNOs. Produced by OXONON. This kit is good for 96 samples. Sensitivity: For all fluids (except plasma): using a plate reader, sensitivity is approximately 500nM. However, if a microcuvette is used in a spectrophotometer, then up to a five-fold increase in sensitivity can be obtained. 1 Kit N-1101 Nitrosocysteine Antibody Description : Source: Rabbit. Immunogen: S-nitrosylated cysteine conjugated to BSA. Cysteine (Cys) was linked to bovine serum albumin (BSA) via glutaraldehyde (G) and Cys-G-BSA was nitrosylated using acified NaNO2 (sodium nitrite). Specificity:The avidity and specificity of the antibody was evaluated using an adapted ELISA method. Samples treated with HgCl2 were used as negative controls. Application: IHC, Dot Blot, ELISA. Used to localize and characterize S-nitrosylated proteins in cells in and tissues. 150 μg N-1079 Nitrotyrosine (CC22.8C7) Description : Immunogen: Peroxynitrite-treated keyhole limpet hemocynanin (KLH). Specificity: Recognizes nitrotyrosine-containing proteins. Clone:CC22.8C7. Isotype: Mouse IgG2b. Application: WB. 50 μg N-1083 Nitrotyrosine (NOY-7A5) Description : Immunogen: Peroxynitrite-treated KLH. Specificity: Recognizes nitrotyrosine in proteins. Clone: NOY-7A5. Isotype: Mouse IgG1. Application: WB, ELISA. 100 μg N-1085 NMMA Description : Negative control for L-NMMA. Does not have any significant effect on Nitric Oxide Synthase. 25 mg D-1027 NMMA Description : A widely utilized inhibitor of Nitric Oxide Synthase (NOS). 25 mg M-1014 NO2-Tyrosine (Rat) Description : Polyclonal antisera were raised in rabbits after immunization with the conjugates: NO2-Tyrosine-Glutaraldehyde-Carriers. Recommended dilution: The anti-conjugatedNO2-Tyrosine antibodies can be diluted between 1/2,000-1/5000. Specificity: Using a conjugate NO2-Tyrosine-Glutaraldehyde-Protein,antibody specificity was performed with an ELISA test by competition experiments with the following compounds: NO2-Tyrosine-G-BSA:1, Tyr-G-BSA: 1/>100,000, NO-Tyr-G-BSA: 1/15,000 , NO2-5HT-G-BSA: 1/>100,000 , NO-5HT-G-BSA: 1/>100,000 , NO-W-G-BSA: 1/>100,000, NO-His-G-BSA: 1/>100,000. 100 μl N-1127 NOC-12 Description : A Nitric Oxide Donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half Life (t1/2) for NO release at 22°-25°C is 327 minutes1. 5mg N-1021 Nogalamycin aglycone Description : Anthracycline antibiotic which binds DNA. Demonstrates antitumor activity. 50 mg N-1157 Nonactin, Streptomyces griseus Description : Macrotetrolide antibiotic which acts as a monovalent cation ionophore and demonstrates high selectivity for ammonium and potassium. 50 mg N-1155 Noxa (Human) (114C307) Description : Immunogen: Recombinant human Noxa. Specificity: Recognizes human Noxa. Detects a band of approx. 11KDa WB. Isotype: Mouse IgG1. Application: WB. 100 μg N-1123 NPC-15437.2HCl Description : Selective Inhibitor of Protein Kinase C. 1 mg N-1077 NPY (Human) Description : H - Tyr - Pro - Ser - Lys - Pro - Asp - Asn - Pro - Gly - Glu - Asp - Ala - Pro - Ala - Glu - Asp - Met - Ala - Arg - Tyr - Tyr - Ser - Ala - Leu - Arg - His - Tyr - Ile - Asn - Leu - Ile - Thr - Arg - Gln - Arg - Tyr - NH2. Merck Index: (Antimycin A1) & 721 (Antimycin A3) 0.5 mg N-1163 NS-2028 Description : A specific inhibitor of soluble guanylyl cyclase (sGC). 1 mg N-1067 Nystatin Product name : Nystatin N-1171 Ochratoxin A, Aspergillus ochraceus Description : A fungal metabolite that causes an increase in endoplasmic reticulum ATP-dependent calcium pump activity. 5 mg O-1034 Octadecylphosphocholine, Synthetic Description : Alkylphosphocholine which acts as an anti-tumor agent. 250 mg O-1070 Octyl-β-D-Glucopyranoside Description : A biological detergent widely utilized for solubilizing membrane bound proteins in their native state. 5 gm O-1036 ODA Description : Inhibitor of LTB4-ω-oxidase and fatty acid ω-hydroxylase. 1 mg O-1068 ODA, Oleamide Description : A sleep inducing brain lipid. Also a novel modulator of 5-Hydroxytrypamine receptors. 10 mg O-1020 ODQ Description : A potent, selective inhibitor of Nitric Oxide sensitive Guanylyl Cyclase (IC50=20 nm). 10 mg O-1022 Okadaic acid, Prorocentrum concavum, High Purity Description : Potent inhibitor of protein phosphatases, especially protein phosphatases 1 and 2 classes. Also used as a tumor promoter. 50 μg O-1024 Okadaic acid.Ammonium Salt, Prorocentrum concavum Description : Potent inhibitor of protein phosphatases, especially protein phosphatase 1 and 2 classes. Also used as a tumor promoter. This salt form provides increased stability in solution. 25 μg O-1026 Okadaic acid.Potassium Salt, Prorocentrum concavum Description : Potent inhibitor of protein phosphatases, especially protein phosphatase 1 and 2 classes. Also used as a tumor promoter. This salt form provides increased stability in solution. 50 μg O-1028 Okadaic acid.Sodium Salt, Prorocentrum concavum Description : Potent inhibitor of protein phosphatases, especially protein phosphatase 1 and 2 classes. Also used as a tumor promoter. This salt form provides increased stability in solution. 25 μg O-1030 Oligomycin A, Streptomyces diastatochromogenes. Product name : Oligomycin A, Streptomyces diastatochromogenes. O-1063 Oligomycin B, Streptomyces diastatochromogenes. Product name : Oligomycin B, Streptomyces diastatochromogenes. O-1064 Oligomycin C, Streptomyces diastatochromogenes. Product name : Oligomycin C, Streptomyces diastatochromogenes. O-1066 Oligomycin, Streptomyces diastatochromogenes Description : Antibiotic that inhibits membrane bound mitochondrial ATPase. Oligomycin Complex; A mixture of A, B, and C isomers. 10 mg O-1060 Olomoucine, High Purity Description : Potent and very selective inhibitor of cdc2, cdk and other cyclin-related kinases. 5 mg O-1032 OMe-GlcNAc Description : Inhibitor of N-acetylglucosamine kinase (Ki=17µM) and N-acetylmannosamine kinase (Ki=80µM). 5 mg M-1205 Ophiobolin A Description : Recently purified metabolite. Please inquire. O-1090 Ophiobolin B Description : Recently purified metabolite. Please inquire. O-1092 Osteoprotegerin, Human, N-terminal Description : Immunogen: Synthetic peptide corresponding to aa 21-39 of astes protegerin. Specificity: To N-terminus (aa 20-39) of human osteoprotegerin (OPG). Clone: OPG1-3. Isotype: Mouse IgG1. Application: ELISA (titer 1:400,000), WB. 100 μg O-1076 Osteoprotegerin: Fc, Human, Recombinant. Description : The cysteine-rich region of human Osteoprotegerin (aa 22-202) is fused to the Fc portion of human IgG1. rhOPG: Fc inhibits soluble TRAIL (sTRAIL)-mediated lysis of TRAIL sensitive cells. Specificity: binds human RANKL (TRANCE) and TRAIL. 50 μg O-1072 Oxoguanine-DNA glycosylase Description : Source: Rabbit. Immunogen: Raised against 8-Oxoguanine-DNA glycosylase of human origin. Specificity: Recognizes hOGG1. Application: WB (in highly expressing cells,1:500-1:1000.) 8-Hydroxyguanine (8-OH-G) is the site of a frequent mutagenic lesion of DNA, produced by oxidative damage. Human 8-Oxoguanine-DNA-glycosylase (hOGG1) is a major enzyme for repair of 8-OH-G-lesion in human cells. 100 μl O-1078 Ozagrel Description : 1-alkyl imidazole derivative that acts as a selective inhibitor of TXAS with an IC50 of 11nM. O-1100 P65PAK Description : Affinity-purified antibody to p65PAK . Raised in rabbits to a synthetic peptide corresponding to residues 484-502 of the human Lymphocyte protein. 100 μl P-1279 P65PAK detection kit Description : Same as Anti-p65PAK except that, an aliquot of p65PAK is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit P-1273 PA28 Activator, Rabbit Description : Protein activator of the 20S proteasome. Enhances the 20S proteasome hydrolysis of peptide substrates (peptidase activity) but not hydrolysis of ubiquinated proteins. Composed of both α and β subunits. Alternative to SDS activation. 10 μg P-1227 Paclitaxel, Taxus brevifolia Description : Anti-tumor agent isolated from the bark of the yew tree. 5 mg P-1027 Palmitoyl - 2 - oleoyl - sn - glycero - 3 - phosphocholine Description : High Purity phospholipid utilized for liposome production. 50 mg P-1189 Panepoxydone from Lentinus critinus Description : Antibiotic isolated from Lentinus critinus. Inhibitor of NF-kB activation by preventing the phosphorylation of IkB protein and thereby interrupts the signalling pathway. 0.5 mg P-1381 PAPA NONOate Description : A Nitric Oxide Donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half Life (t1/2) for NO release at 37°C is 15 minutes1. Half Life (t1/2) for NO release at 22°-25°C is 77 minutes1 25 mg P-1007 Paraherquamide A Description : Recently purified metabolite. Please inquire. P-1470 Paraherquamide E Description : Recently purified metabolite. Please inquire. P-1471 PARP-1 (human) Description : Source: Rabbit. Immunogen: Recombinant human PARP-1 (poly(ADP-ribose)polymerase-1) (aa 215-525) expressed in SF21 cells Application: ICC, IHC, IP, WB 100 ul P-1522 Parthenolide Description : Inhibits activation of MAP kinase. Also anti-inflammatory and anti-secretory. 50 mg P-1233 Patulin Description : Mycotoxin which inhibits the uptake of potassium. 5 mg P-1097 Paxilline, Penicillium paxilli Description : Potent inhibitor of Ca activated K(maxi K) channel. 10 mg P-1029 PBDA Description : Acts as a potent inhibitor of glutamate carboxypeptidase II (NAAG peptidase) and an mGluR3-selective agonist. 1 mg P-1181 PCCG-13 Description : Potent and selective antagonist of mGluR mediated PLD response. 1 mg P-1085 PCCG-4 Description : Selective mGluR antagonist. 1 mg P-1067 PD 169,316 Description : Potent, cell Permeable and selective inhibitor of p38 (SAPK2a). 1 mg P-1185 PD-153,035 Description : A tyrosine kinase inhibitor. Also inhibits Epidermal Growth Factor. 5 mg P-1237 PD-98059 Description : Cell-permeable, potent and specific inhibitor of MAP Kinase (MEK or MAPK/ERK). By selectively blocking the activity of MEK, it also inhibits the phosphorylation and activation of MAP kinase. 5 mg P-1019 Penicillic Acid Description : Antibiotic, Mycotoxin that induces DNA single-strand breaks. Anti-HIV Activity. 10 mg P-1179 Penitrem A, Penicillium paxilli Description : Potent inhibitor of Ca activated K(maxi K) channel. inhibits binding of charybdotoxin. 5 mg P-1031 Pentoxyifylline Description : Phosphodiesterase inhibitor. Blocks the synthesis of TNF-α. 1 g P-1099 Peptide YY (3-36) [PYY3-36] (Human) Description : Peptide YY (3-36) [PYY3-36] is a Y2R agonist, inhibiting food intake and reducing weight gain in rats and humans after peripheral injection 500 μg N-1165 Perforin (CB5.4) Description : Specificity: Raised against mouse perforin (aa 98-534). Recognizes human and mouse perforin. Isotype: Rat IgG2a. Application: ICC, IHC (FS, PS),WB. 100 μg P-1303 Perforin (CE2.10) Description : Specificity: Raised against mouse perforin (aa 98-534). Recognizes human and mouse perforin. Isotype: Mouse IgG2a. Application: IP, WB (only mouse). 100 μg P-1299 Perforin (Human) (δ G9) Description : Specificity: Recognizes human perforin (70kDa). Blocks in vitro pore formation when using purified perforin. Isotype: mouse lgG2b. Application: FC (detergent permeabolized formaldehyde fixed cells), IP, IHC (FS, PS). FITC 120 tests P-1301 Perilipin A (Mouse) Description : Immunogen: Synthetic peptide corresponding to aa 502-517 (E502PILGRTQYSQLRKKS517) of rat perilipin A. This sequence is 93% conserved in human perilipin A. Specificity: Recognizes mouse perilipin A. Detects a band of ~62kDa by Western blot. Figure: Western blot of perilipin A in 3T3-L1 cell extract using anti-perilipin A Pab. 100 μl P-1397 Perilipin A/B (Mouse) Description : Immunogen: Synthetic peptide corresponding to aa 1-17 (M1SMNKGPTLLDGDLPEQ17) of rat perilipin A and B. This sequence is 82% conserved in human perilipin. Specificity: Recognizes mouse perilipin A and B. Detects bands of ~62 kDa (perilipin A) and ~46kDa (perilipin B) by Western blot. Figure: Western blot on perilipin A and B in 3T3-L1 cell extract using anti-Perilipin A/B Pab. 100 μl P-1399 Peripherin Description : Source: Rabbits were immunized recombinant peripherin. Cross-Reactivity: Mammal. Application: ICC/IF (1/100 - 1/1,000), WB (1/1,000 - 1/5,000). Peripherin is a member of the intermediate filament protein family. It is found in neurons of the central nervous system and in sensory neurons of the peripheral nervous system and thus is a useful neuronal-specific marker. 50 μg P-1484 Peripherin (7C5) Description : Peripherin is a member the intermediate filament protein family. It is found in neurons of the central nervous system and in sensory neurons of the peripheral nervous system and thus is a useful neuronal-specific marker. Source: Mice were immunized with a recombinant rat peripherin. Cross-Reactivity: Mam, Ck. Application: ICC/IF (1/500 – 1/5,000), WB (1/500 - 1/2,500). Immunoglobulin isotype is IgG1. 0.2 ml P-1486 Peripherin (8G2) Description : Source: Mice were immunized with a recombinant rat peripherin. Cross-Reactivity: Mam, Ck. Application: ICC/IF (1/200 – 1/1,000) WB (1/500 – 1/2,500). Immunoglobulin isotype is IgG1. Peripherin is a member the intermediate filament protein family. It is found in neurons of the central nervous system and in sensory neurons of the peripheral nervous system and thus is a useful neuronal-specific marker. 0.2 ml P-1488 Peripherin (Per-56) Description : Source: Rabbits were immunized with a synthetic peptide based on amino acid residues n-CLLRPQEL-c which are unique to the Per-56 isoform. Cross-Reactivity: Hu, Ms, Rt. Application: ICC/IF (1/100 - 1/1,000), WB (1/500 - 1/2,500). Peripherin is a member of the intermediate filament protein family. It is found in neurons of the central nervous system and in sensory neurons of the peripheral nervous system and thus is a useful neuronal-specific marker. 50 μg P-1490 Peripherin (Per-61) Description : Source: Rabbits were immunized with a synthetic peptide based on amino acid residues n-EWR CAS QPG LSA TAQ-c which are unique to the Per-61 isoform. Cross-Reactivity: Hu, Ms, Rt. Application: ICC/IF (1/100 - 1/1,000), WB (1/500 - 1/2,500). Peripherin is a member of the intermediate filament protein family. It is found in neurons of the central nervous system and in sensory neurons of the peripheral nervous system and thus is a useful neuronal-specific marker. 50 μg P-1492 Peroxynitrite.tetramethylammonium Salt Description : Peroxynitrite. tetramethylammonium salt is a pure form of peroxynitrite. Unlike other forms it contains no nitrite, nitrate, metal ions or hydrogen peroxide contaminants. 1 ml P-1005 Pesta Description : Recently purified metabolite. Please inquire. P-1472 PGP-4008 Description : Selectively inhibits P-glycoprotein. Effectively reverses Pgp-mediated drug resistance in NCI.ADR cells, but has not effect on the drug sensitivities of MCF7/VP cells that overexpress MRP1. 2 mg P-1267 PHAS-1 Substrate, (Recombinant) Description : A highly specific substrate for MAPK both in vivo and in vitro. Also can be a useful in vitro substrate for p38 and PKC. 250 μg P-1021 Phenamil.Methanesulfonate Description : A derivative of amiloride, which acts as a sodium channel blocker. 5 mg P-1017 Phenanthroline. Monohydrate Description : Acts as a general metalloprotease inhibitor. Chelates iron, zinc and other divalent metals. Forms a red chelate with Fe2+ that absorbs maximally at 510 nm and can be used as a photometric reagent for iron. When complexed with copper it possesses nuclease activity that has been used to study DNA-protein interactions. 500 mg P-1520 Phenoxybenzamine.HCl Description : Inhibitor of calmodulin. Selective blocker of α-adrenergic. 200 mg P-1235 Phorbol-12-myristate-13-acetate Description : Potent mouse skin tumor promoter. Also activates Protein Kinase C. 1 mg P-1039 Phosphatidylinositol - 4 , 5 , - biphosphate, Purified Description : Immunogen: Synthetic PtdIns(4,5)P2 (1) in liposomes. Specificity: Shown to recognize PtdIns(4,5)P2 in murine and human cells. Clone: 2C11. Application: 1:500 for dot blot. 1:250 for TLC overlay and ELISA. 1:50 IHC, IF. 100 &#956;l P-1219 Phosphatidylinositol 3-Kinase p85a Product name : Phosphatidylinositol 3-Kinase p85a P-1269 Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide Description : Selectively binds to PI3K SH3 (Km=7.6 μm). 1 mg P-1143 Phosphatidylinositol-3, 4, 5-trisphosphate Description : Shown to recognize PtdIns(3,4,5)P3 in murine and human cells. Crossreactivity is 1% or less with other phosphatidylinositol phosphates or lipids. Suggested Usage: 1:50 for fluorescence immunohistochemistry or cytochemistry. A detailed procedure for visualization of PtdIns(3,4,5)P3 in PDGF or insulin-stimulated, permeabilized cells using biotinylated anti-mouse IgM and a fluorescent streptavidin. 100 &#956;g P-1173 Phosphatidylserine Receptor (217) Description : Immunogen: Human macrophages stimulated with TGF(β) and (β)-glucan for 48 hours. Specificity: Recognizes human, mouse and chicken phosphatidylserine receptor. Isoytpe: Mouse IgM. Application: FC,WB,FUNC. 200 μg P-1305 Phosphoinositide 3-kinase p110 α/p85 (bovine) (Recombinant) Description : Phosphoinositide 3-kinases (PI(3)K´s) phosphorylate the 3´-OH position of inositol phospholipids. The heterodi-meric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85α). Specific Activity: ~1nmole/min/mg using phosphatidylinositol as the substrate. Source: Produced in insect cells. Bovine recombinant PI(3)K p110α/p85 dimer untagged. *M.W.: : 83.5kDa, p110α: 124.3 kDa. 5 μg P-1423 Phosphoinositide 3-kinase p110 γ (H1) Description : Specificity: Recognizes human and mouse phosphoinostitde 3-kinase (P(3)K) p110 γ. The epitope is in the region aa 97-335. Does not cross-react with P110α, P110β, P110δ. Clone: H1, Isotype: Mouse IgG2a. Immunogen: Human phosphoinositide 3-kinase (PI(3)K) p110 γ peptide. Application: Western Blot. Purity is determined by as determinded by SDS-gel electrophoresis. 1 mg P-1289 Phosphoinositide 3-kinase p110 γ (Human) (Recombinant) Description : Phosphoinositide 3-kinases (PI(3)K´s) phosphorylate the 3´-OH position of inositol phospholipids. The heterodi-meric complex consists of a catalytic subunit (p110α) and a regulatory adaptor subunit (p85α). Specific Activity: ~4.5nmoles/min/mg using phosphatidylinositol as the substrate. Source: Full length human PI(3)K p110γ, fused with a His6-tag at the C-terminus; expressed in insect cells. Quantity: 10ug. 10 μg P-1291 Phosphoinositide 3-kinase p110δ (Human) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 1026-1044 (S1026WKTKVNWLAHNVSKDNRQ1044) of the C-terminal domain of human phosphoinositide 3-kinase (PI(3)K) p110δ. Specificity: Recognized human PI(3) p110δ. Application: Immunocytochemistry (1:300), Western Blot (1:1,000). Detects a band of~110kDa by Western blot. 100 μl P-1293 Phospholipase C, Phosphatidylinositol-specific Description : May be used to release phosphatidylinositol (PI)-linked proteins from membranes. One unit will liberate one unit of acetylcholinesterase per minute from a membrane bound crude preparation at pH 7.4, 30°C (10 min. incubation). 5 U P-1425 Phosphoramidon Description : Endothelin converting enzyme inhibitor. 1 mg P-1101 Phthalimidino-glutaric acid Description : Stable analog of Thalidomide with increased anti-tumor potency. 5 mg P-1187 PI(3)P, di C16 Description : Natural occurring form. Substrate for PIP4K alplha and β. 100 μg P-1133 PI(3)P, di C8 Description : Water soluble form. Substrate for PIP4K α and β. 100 μg P-1131 PI(3)P-Na+, di C16 Product name : PI(3)P-Na+, di C16 100 μg P-1409 PI(3,4)P2, di C16 Description : Natural occurring form. Substrate for PIP5K. Inhibited by PI(4,5)P2. 100 μg P-1121 PI(3,4)P2, di C8 Description : Water soluble form. Substrate for PIP5K. Inhibited by PI(4,5)P2. 100 μg P-1119 PI(3,4)P2-Biotin, Na+ Product name : PI(3,4)P2-Biotin, Na+ 200 μg P-1419 PI(3,4)P2-Na+, di C16 Description : Substrate for PIP5K. Inhibited by PI(4,5)P2. 100 μg P-1401 PI(3,4,5)P2-Biotin, Na+ Product name : PI(3,4,5)P2-Biotin, Na+ 200 μg P-1421 PI(3,4,5)P3, di C16 Description : Natural occurring form. 100 μg P-1129 PI(3,4,5)P3, di C8 Description : Water soluble form. 100 μg P-1127 PI(3,4,5)P3-Na+, di C16 Product name : PI(3,4,5)P3-Na+, di C16 100 μg P-1403 PI(3,4,5)P3-Na+, di C8 Product name : PI(3,4,5)P3-Na+, di C8 100 μg P-1405 PI(3,5)P2, di C16 Description : Natural occurring form. 100 μg P-1125 PI(3,5)P2, di C8 Description : Water soluble form. 100 μg P-1123 PI(3,5)P2-Na+, di C16 Product name : PI(3,5)P2-Na+, di C16 100 μg P-1407 PI(4)P, di C16 Description : Natural occurring form. Substrate for PIP5K and PI3K (Class IA, IB, II). 100 μg P-1137 PI(4)P, di C8 Description : Water soluble form. Substrate for PIP5K and PI3K (Class IA, IB, II). 100 μg P-1135 PI(4)P-Na+ di C16 Product name : PI(4)P-Na+ di C16 100 μg P-1411 PI(4,5)P2, di C16 Description : Natural occurring form. Substrate for PI3K (Class IA, IB, II). 100 μg P-1117 PI(4,5)P2,di C8 Description : Water soluble form. Substrate for PI3K (Class IA, IB, II). 100 μg P-1115 PI(4,5)P2-Biotin, Na+ Product name : PI(4,5)P2-Biotin, Na+ 200 μg P-1417 PI(4,5)P2-Na+ di C16 Product name : PI(4,5)P2-Na+ di C16 100 μg P-1413 PI(5), di C16 Description : Natural occurring form. Substrate for PIP4K α and β. Inhibited by PI(4,5)P2. 100 μg P-1141 PI(5), di C8 Description : Water soluble form. Substrate for PIP4K α and β. Inhibited by PI(4,5)P2. 100 μg P-1139 PI(5)-Na+ di C16 Product name : PI(5)-Na+ di C16 100 μg P-1415 PI-3 Kinase, Human, Recombinant (Mouse) Description : Reacts with p85α which is the regulatory subunit of PI 3-kinase. Does not react with p85β. Clone: AB6, Isotype: Mouse, IgG1κ. Application: Western Blot, Immunocytochemistry, Immunoprecipitation, Crossreactivity with other species has not been determined, Immunogen: Recombinant Human p85α expressed in E. coli. 100 μg P-1145 Piceatannol Description : Inhibits the protein tyrosine kinase Syk. 10 mg P-1015 Piericidin A Description : Recently purified metabolite, please inquire. P-1474 Piericidin B Description : Recently purified metabolite. Please inquire. P-1476 Piericidin C Description : Recently purified metabolite. Please inquire. P-1478 Pifithrin-α.hydrobromide Description : Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53 dependent transcriptional activation and apoptosis. 10 mg P-1177 Pimprinine Description : Recently purified metabolite. Please inquire. P-1480 Piperacillin, Sodium Salt Description : Antimicrobial agent 5 g P-1506 Piperafizine A Description : Recently purified metabolite. Please inquire. P-1482 Pironetin A Product name : Pironetin A P-1453 PJ-34 Description : Potent, water-soluble poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor. 1 mg P-1455 PK-11195 Description : Benzodiazepine antagonist. 50 mg P-1013 Polymyxin B Sulfate, Bacillus polymyxa Description : Antibacterial antibiotic that acts as inhibitor of protein kinase C (PKC). 1 g P-1494 Ponasterone A Description : Insect steroid hormone involved in regulating metamorphosis. Suitable inducer of ecdysone-inducible mammalian expression system, so can be used in place of muristerone A. 1 mg P-1083 POPE Product name : POPE 50 mg P-1526 PP1 Description : Cell permeable, selective inhibitor of Src family tyrosine kinases. 1 mg P-1087 PP2 Description : Potent and selective inhibitor of the src family of tyrosine kinases. 1 mg P-1103 PP2A Description : Antiserum raised in rabbits to the catalytic subunit of bovine kidney PP2A. Useful for Western blotting, for example, with 30 mg bovine liver extracts and the antibody at 1:200 dilution. 200 μl P-1275 PP2A detection kit Description : Same as Anti-PP2A, except that an aliquot of PP2A is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit P-1271 PP2A detection kit Description : Same as Anti-PP2A, except that, a PP2A aliquot is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. 1 Kit P-1277 PP36 (Human) Description : pp36 is an adaptor protein that bridges proximal T-cell antigen receptor (TCR) signals to the activation of phosphoinositide turnover, Ras and perhaps other signaling pathways in T-cells. Application: Immunocytochemistry (1:300), Western Blot (1:1,000). Specificity: Recognizes human pp36. Detects a band of ~40kDa by Wesern Blot. Source: Source: Rabbit. Immunogen:Synthetic peptide corresponding to aa 29-49 (C29HRLPGSYDSTSSDSLYPRGI49) of the N-terminal extracellular domain of human pp36. 100 μl P-1295 PPAHV Description : Ligand with various binding profiles dependent on vanilloid receptors. 1 mg P-1095 PPARα Description : Immunogen: Purified rec. PPARa. Specificity: Recognizes human, mouse and rat PPARa (~52kDa). Clone: 3B6/PPAR. Isotype: Mouse IgG2b. Application: IP, WB (2-5 μg/ml). 100 μg P-1193 PPARα, Purified (Mouse) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 1-18 (M1VDTESPICPLSPLEADD18) of mouse PPARα. Specificity: Recognizes mouse, human, and rat PPARα. Detects a ~52 kDa band in WB. Does not cross-react with PPARδ or PPARγ. Inhibits PPARα DNA binding in GS. Application: HIS, GS, WB, FUNC. A single aa substitution (I8-L8) exist between mouse and human PPARα. 100 μl P-1197 PPARγ, Mouse Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 284-298 (M284MGEDKIKFKHITPL298) of mouse PPARγ2. Specificity: Recognizes the adipose specific PPARγ2 isoform in mouse 3T3-L1 cells. Sequence is completely conserved in PPARγ1 but exhibits no significant homology with PPARα or NUC1. 100 μl P-1201 PPARγ2, Mouse, Purified Description : Synthetic peptide corresponding to aa 1-16 (M1GETLGDSPIDPESDS16) of human PPARg2. Specificity: Recognizes mouse PPARg2. Detects a band of ~56 kDa by Western Blot. Does not cross-react with PPARa or PPARd. Immunohistochemistry (1:500), Western Blot (1:500), Gel Supershift Assay, Functional Application (inhibits PPARg2 DNA binding). 100 μl P-1203 PPARδ, Mouse, Purified Description : Source: Rabbit. Immunogen: Unique Synthetic peptide corresponding to aa 1-14 (M1EQPQEETPEAREE14) of mouse PPARδ. Sequence is 86% conserved in human PPARδ. Specificity: Recognizes mouse PPARγ. Detects a ~49 kDa band in WB. Does not cross react with PPARα or PPARγ. Application: IHC, GS, WB. 100 μl P-1199 PPAR, Mouse Description : Source: Rabbit. Immunogen: Synthetic peptite corresponding to the C-terminal region (I484KKTETDMSLHPLLQ498) of PPARγ2. Specificity: Recognizes mouse PPARγ2 (~55 kDa) in WB. Also reacts with rec. rat PPARα in WB and rec. mouse PPARγ1 by IP. Sequence is highly conserved in mouse, human, rat PPARγ1, PPARα and NUC1. 100 μl P-1205 Procathepsin W (Human) (CW 40-1B1) Description : Specificity: Recognizes the epitope E76EFGQLY82 of human procathepsin W. Clone: CW-40 1B1. Isotype: Mouse IgG1.Does not cross-react with mature cathepsins B, D, H, K, L, S, W or procathepsins B, F, L, S. 200 μg C-1381 Profilin, Purified Description : Source: Rabbit. Immunogen: Porcine platelet profilin. Specificity: Recognizes human, porcine, bovine, mouse, rat, chicken and marsupial profilin I & II. Application: WB. Includes positive control (500 μg of human platelet protein). Profilin is a ubiquitous small (12-15kDa) phosphoinositide and poly-L-proline binding protein that plays a role both in signal transduction pathways and actin filament dynamics. 100 μl P-1215 PROLI NONOate, PROLI/NO Description : A Nitric Oxide Donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half Life (t1/2) for NO release at 37°C is N.D1.Half Life (t1/2) for NO release at 22°-25°C is 1.8 seconds1 25 mg P-1009 Propyl-L-arginine Description : Potent inhibitor of neuronal Nitric Oxide Synthase (nNOS). 5 mg P-1175 Prostaglandin F2α Description : Potent vasoconstrictor in rat lung and kidney where its effects seem to be mediated through thromboxane receptors. However, evidence exists for a separate and distinct isoprostane receptor. May play a role in pulmonary oxygen toxicity. 1 mg P-1207 Proteasome Description : Enzyme which is the catalytic core of the 26S proteasome that degrades polyubiquitinated proteins. Known to hydrolyze various peptide substrates and proteins with broad specificity in a non-ATP-dependent process. 25 μg P-1225 Proteasome Fraction, Mammalian Description : Partially purified fraction containing 26S proteasome and none of the conjugation enzymes (E1, E2s, E3s). Preferred for the degradation of pre-formed ubiquitin-protein conjugates by the 26S proteasome since highly purified 26S is costly and more labile. Source: Hela S3 cells. 200 μl U-1046 Proteasome Inhibitor I (aldehyde) Description : Cell-permeable inhibitor of the multicatalytic proteinase complex (MPC, 20S proteasome) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. 1 mg P-1149 Proteasome Inhibitor II (aldehyde) Description : Potent and cell-permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC, 20S proteasome). Does not inhibit the peptidylglutamyl peptide hydrolyzing activity of the MPC. 1 mg P-1151 Proteasome Substrate I (Fluorogenic) Description : Fluorogenic proteasome substrate. Good for measuring the peptidase activity of the 20S proteasome 1 mg P-1159 Proteasome Substrate II (Fluorogenic) Description : Fluorogenic proteasome substrate. Good for measuring the peptidylglutamyl peptide-hydrolyzing activity of the 20S proteasome. 1 mg P-1161 Proteasome Substrate III (Fluorogenic) Description : Fluorogenic proteasome substrate. Also acts as a substrate for many other proteinases. Good for measuring the chymotrypsin-like peptidase activity of the 20S proteasome 1 mg P-1163 Proteasome Substrate IV (Fluorogenic) Description : Fluorogenic substrate for Alzheimer's disease amyloid A4-generating enzymes and for measuring the peptidase activity of the 20S proteasome. 1 mg P-1165 Protein phosphatase 2A, Subunit A Glu416; Inactive Mutant Description : AGlu416 contains a mutation in a basic motif that is an important determinant for the interaction of the A and catalytic subunits of PP2A. The AGlu416 preparations can be useful as control in reconstitution studies and for further delineating the functional significance of the basic motif. 1 μg A-1240 Protein Solubilizer 20, Ready to use Ampules, Sterile Description : Non-ionic Detergent useful for immunoprecipitation and solubilizing proteins. (CMC 0.059 mM, HLB 16.7). 10% aqueous solution aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (< 80-100 uM) enable the highest retention of protein activity. Extremely low conductivity levels (20 umhos) provide low ionic concentrations which are essential for applications such as electrophoresis. 10 x 5 ml P-1502 Protein Solubilizer 35, Ready to use Ampules, Sterile Description : Non-ionic Detergent useful for solubilizing proteins. It has very low UV absorbance. (CMC 0.09 mM, HLB 16.9, Agg. No. 40, ). 10% aqueous solution aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (< 80-100 uM) enable the highest retention of protein activity. Extremely low conductivity levels (20 umhos) provide low ionic concentrations which are essential for applications such as electrophoresis. 10 x 5 ml P-1504 Protein Solubilizer 40, Ready to use Ampules, Sterile Description : Non-ionic surfactant useful for the isolation and purification of functional membrane proteins. (CMC 0.05-0.3 mM, HLB 13.1, Cloud Point 80°C. ). 10% aqueous solution aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (< 80-100 uM) enable the highest retention of protein activity. Extremely low conductivity levels (20 umhos) provide low ionic concentrations which are essential for applications such as electrophoresis. 10 x 5 ml P-1505 Protein Solubilizer 80, Ready to use Ampules, Sterile Description : Non-ionic Detergent. 10% aqueous solution aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (< 80-100 uM) enable the highest retention of protein activity. Extremely low conductivity levels (20 umhos) provide low ionic concentrations which are essential for applications such as electrophoresis. 10 x 5 ml P-1498 Protein Solubilizer Set 1, Ready to use Ampules, Sterile Description : Active ingredient: supplied as a highly purified, Sterile, 10% aqueous solution of Tween-80, Tween-20, Triton X-100, NP-40 and Brij-35 (5 Sample Set: 2x5ml each) 5 Sample Set P-1508 Protein Solubilizer X-100, Ready to use Ampules, Sterile Description : Non-ionic Detergent useful for isolation of membrane proteins. (CMC 0.2-0.9 mM, HLB 13, Cloud Point 64°C). 10% aqueous solution aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (< 80-100 uM) enable the highest retention of protein activity. Extremely low conductivity levels (20 umhos) provide low ionic concentrations which are essential for applications such as electrophoresis. 10 x 5 ml P-1500 Protein Solubilizer X-114, Ready to use Ampules, Sterile Description : Non-ionic Detergent & Emulsifier. (CMC 0.35 mM, HLB 12.4, Cloud Point 22°C). 10% aqueous solution aseptically filled under GMP conditions with pharmaceutical grade water. Extremely low aldehyde & peroxide impurities (< 80-100 uM) enable the highest retention of protein activity. Extremely low conductivity levels (20 umhos) provide low ionic concentrations which are essential for applications such as electrophoresis. 10 x 5 ml P-1496 Proteinase Inhibitor 9 (Human) (PI9-17) Description : Specificity: homologous serpins (PI6, PI8 and PAI-2). Recognizes human PI9. Does not cross-react with other Detects bands of ~42kDa (native PI9) and ~63kDa (PI9 complexed to granzyme B) by Western blot. 125 μg P-1383 Proteinase K Description : Proteinase K is a non-specific serine protease used in the following applications: inactivation of Rnase and Dnases, isolation of high molecular weight DNA, isolation of RNA or the isolation of plasmid and genomic DNA. Proteinase K is active with or without the presence of SDS, EDTA and Urea. 100 mg P-1265 Ptdlns(3,4)P2/AM Description : Membrane-permeant Phosphatidyl-D-myo-Inositol-3,4-Bisphosphate derivative. 100 μg P-1311 Ptdlns(3,4,5)P3/AM Description : Membrane-permeant Phosphatidyl-D-myo-inositol-3,4,5-trisphosphate derivative. 100 μg P-1313 Ptdlns(3,5)P2/AM Description : Membrane-permeant Phosphatidyl-D-myo-Inositol-3,5-Bisphosphate derivative 100 μg P-1315 PTEN (Purified) Description : Specificity: Raised against a fusion protein containing the C-terminal human PTEN sequence. Detects a ~60 kDa band of human and mouse PTEN by Western Blot. Clone: 6H2.1. Isotype: Mouse IgG. Application: WB, IHC, ICC. PTEN plays an important role in the modulation of the 1-phosphatidylinositol 3-kinase pathway. PTEN inhibits downstream functions mediated by PtdIns 3-kinase pathway such as activation of PKB, cell survival and cell proliferation. 100 μl P-1195 Puromycin, Cell Culture Tested Description : Antibiotic used for selecting mammalian cell lines ,which have been transformed by vectors that express puromycin-N-acetyl-transferase. 25 mg P-1033 Puromycin, Solution, Cell Culture Tested Description : Antibiotic used for selecting mammalian cell lines ,which have been transformed by vectors that express puromycin-N-acetyl-transferase. 10 ml P-1033-SOL Purvalanol A Description : Selective inhibitor of the human Cdk2/cyclin A and Cdc2/cyclin B kinase complex. More membrane-permeable than purvalanol B. 1 mg P-1209 Pyrrolidine-2,4-dicarboxylic acid Description : Potent and selective glutamate uptake inhibitor. P-1037 Pyrrolostatin, Streptomyces chrestomyceticus Description : Potent inhibitor of lipid peroxidation (IC50=49µM; inhibition of lipid peroxidation in rat brain homogenate). Isolated from Streptomyces chrestomyceticus. 100 μg P-1217 Quebrachitol Description : Key starting material for synthesis of optically active inositol phosphates. 1 g Q-1002 Quinaldopeptin A Description : Recently purified metabolite. Please inquire. Q-1110 Quinomycin A Description : Recently purified metabolite, please inquire. Q-1112 Quisqualic Acid Description : Agonist at Quisqualate / AMPA ionotropic receptors. Activity at metabotropic glutamate receptors. 5 mg Q-1000 Radicicol, Humicola fuscoatra Description : Radicicol, a macrocyclic antifungal antibitotic, has been shown to bind to a highly conserved pocket in the Hsp90 (heat shock protein 90) chaperone protein and inhibit the intrinsic ATPase activity of Hsp90. 1 mg R-1130 RANK (Human) Description : Immunogen:Recombinant human RANK (aa326-616). Specificity: The antibody recognizes human RANK. Detects a protein of approx. 66-67 kDa. Clone: 9A725. Isotype: Mouse IgG1. Appication: WB. 100 μg R-1116 RANKL Description : Specificity: Raised against a fusion protein containing aa 1-317 of mouse RANKL. Detects a 40 kDa band in human and mouse. Clone: 12A668. Isotype: Mouse IgG1. Application: WB. 100 μg R-1112 RANKL, Soluble, Human, Rec. Description : Specificity: rhsRANKL binds to human and mouse RANK (TRANCE-R). Application: Supports the survival of dendritic cells and osteoclasts. Recombinant, human sRANKL binds to Osteoprotegerin. 10 μg R-1110 Rapamycin, Streptomyces hygroscopicus Description : Triene macrolide antibiotic which demonstrates immunosuppressive properties. It has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase. Also anti-inflammatory. 1 mg R-1018 Ratjadone (synthetic) Description : Belongs to the family of orphan ligands which include polyketides like leptomycin B, callystatin A and other related compounds. Cytotoxic secondary metabolite (IC50=50 pg/ml in mouse cell line L929) That arrests tumor cell in the G1 phase at remarkably low concentrations (50 pg/ml in HeLa cell line KB3.1). More potent than leptomycin B and specific for G1/S checkpoint. Inhibits the binding between the nuclear export signal (NES) of proteins and the chromosome maintenance region protein (CRM1). Anticancer compound. 2 μg R-1128 Ratjadone C (native) Description : Cytotoxic secondary metabolite that inhibits cell growth of mammalian cell lines in the picomolar range (IC50=0.2ng/ml with L929 mouse cells) including multi-drug resistant HeLa cells (IC50=0.1ng/ml with KB-V1). 5 μg R-1143 Ravidomycin Description : Anti-tumor, antigram postive and anti-mycobacteria properties. R-1170 Resiniferatoxin,Euphorbia poisonii, High Purity Description : RTX vanilloid receptor antagonist. Potent capsaicin analog. 1 mg R-1094 Resistin (dup of R-1134) Description : Duplicate of R-1134 R-1142 Resistin (Human) Description : Source: Rabbit. Immunogen: His-tagged human resistin fusion protein. Specificity: Recognizes human resistin. Application: ELISA, Western blot. 100 μg R-1140 Resistin (Human) (HRES 106) Description : Immunogen: Recombinant human resistin expressed in mammalian cells. Isotype: Mouse IgG2a. Western blot analysis of recombinant resistin with AX106 at a concentration of 0.2µg/ml. 50 μg R-1138 Resistin (Human) (Recombinant) Description : Source: Produced in E. coli. Human resistin is fused at the N-terminus to a spacer (31 aa) and a His-tag. Reconstitution: Reconstitute with 100µl distilled water and let the pellet dissolve completely. Application: ELISA, Western blot. 100 μg R-1136 Resistin (Human) ELISA Kit Description : Sensitivity: 0.2ng/ml. Quantity: 96 wells. Application: Quantitative measurement of human resistin in serum, plasma and tissue culture medium. 1 Kit R-1146 Resistin (mouse) Description : Source: Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 21-39 (S21SMPLCPIDEAIDKKIKQD39) of mouse resistin. Specificity: Recognizes mouse resistin. Detects a band of ~14 kDa by Western blot. Application: Western blot (2µg/ml). 100 μg R-1144 Resistin (mouse) (MRES 06) Description : Specificity:Recognizes mouse resistin. Detects a band of ~14kDa by Western blot. Does not cross-react with human resistin. 50 μg R-1134 Resveratrol Description : Minor product found in wine and grapes. Found to reduce serum lipids, inhibit platelet aggregation, as well as, act as a chemopreventative agent and an antioxidant. 50 mg R-1014 Retinal Product name : Retinal R-1048 Retinoic Acid Product name : Retinoic Acid 1 g R-1050 Retitulol Description : Recently purified metabolite. Please inquire. R-1160 Reveromycin A Description : Recently purified metabolite. Please inquire. R-1162 Reveromycin A Description : Epidermal Growth Factor Inhibitor. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). A G1 phase cell cycle inhibitor displaying antiproliferative behavior against human cell lines KB and K562 as well as antifungal activity. Please inquire. R-1200 Reveromycin B Description : Recently purified metabolite. Please inquire. R-1164 Reveromycin C Description : Recently purified metabolite. Please inquire. R-1166 Reveromycin D Description : Recently purified metabolite. Please inquire. R-1168 Reversin 121 Description : Selective high affinity inhibitor of Pgp. 5 mg R-1124 Reversin 205 Description : Selective high affinity inhibitor of Pgp. 5 mg R-1126 Riluzole Description : Glutamate release inhibitor. 50 mg R-1034 Ristocetin.sulfate, Nocardia lurida Description : A glycopeptide antibiotic used in the diagnosis of the bleeding disorder, von Willebrand's disease (VWD). Ristocetin CoFactor Activity Assay is used to diagnose VWD while the Ristocetin Induced Platelet Agglutination (RIPA) Assay provides an overall assay of ristocetin induced agglutination of the patient's own platelets and plasma. This assay detects VWD cases with a hyperaggregation tendency. Purity data is for Ristocetin A. 100 mg R-1111 Ro 20-1724 Description : Selective, potent cAMP phosphodiesterase inhibitor. Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. 100 mg R-1096 Rolipram Description : Selective inhibitor of cAMP-specific phophodiesterase, PDE IV. 5 mg R-1012 Roscovitine Description : Potent and selective inhibitor of cyclin-dependent kinases (cdks). Selective for CDK1, CDK2, and CDK5. 5 mg R-1016 Rosmarinic acid Description : Naturally-occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25µg/ml. Isolated from Rosmarinus officinalis. 50 mg R-1122 Rottlerin Description : Powerful inhibitor of PKCδ. 10-fold more potent to PKCδ than PKCα or PKCβ. Also inhibits Ca2+/Calmodulin dependent kinase III. 10 mg R-1120 Rubromycin, Streptomyces Sp. Description : A quinone antibiotic that inhibits HIV-1 reverse transcriptase (RT). Cytostatically active against different tumor cell lines. Inhibits Human telomerase. 1 mg R-1118 Ryanodine Description : Natural Ca2+ blocker, which acts at the sacroplasmic reticulum. 5 mg R-1044 S-100 Fraction, Hela Description : Contains the full Hela cell compliment of E1, E2s, 20S and 26S proteasome, isopeptidase, PA28, and E3 enzymes. Ideal for demonstrating ubiquitin proteasome degradation/conjugation of radiolabeled or immunodetectable substrates. Source: Hela S3 cells. 2.5 mg U-1050 S-Nitrosoglutathione Description : New Polyclonal antibody for the detection of S-Nitrosoglutathione (GSNO). Useful as a tool to investigate the level of GSNO in human plasma proteins. Suitable for a variety of applications. Application: Immunoblotting, Immunoprecipitation, ELISA, Immunohistochemistry, Immunocytochemistry, Recommended dilution:1/2,000 -1/5,000 100 μl N-1125 Saclofen Description : Selective GABAB receptor antagonist. 10 mg S-1028 Sangivamycin Description : Recently purified metabolite. Please inquire. S-2050 SAP Kinase 1 [JNK] Description : Specificity: To the FMMTPYVV peptide motif of SAPK1 [JNK]. Clone: 8D3. Isotype: Mouse IgG1. Application: ELISA,WB. Includes positive control. 100 μg S-1106 SB-202190 Description : Potent and cell permeable inhibitor of p38 (SAPK2a). Inhibits p38α and p38β isoforms. Good for probing p38 MAP kinase function in vivo and in vitro. 1 mg S-1080 SB-203580 Description : A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase. 1 mg S-1014 SB-203580 in Solution Description : A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP Kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase. 1 ml S-1015 SB202190.HCl Description : A water soluble form of the potent p38 (SAPK2a) inhibitor SB202190. 1 mg S-1096 SC68376 Description : Pharmacologic inhibitor of p38 (SAPK2a), IC50=2-5uM. 1 mg S-1098 Sceptrin.dihydrochloride, Agebs Nakamurai Description : Isolated from the sponge Agelas nakamurai. Inhibits the growth of several gm-positive and gm-negative bacteria. Competitively inhibits muscarinic Acetylcholine receptors. 1 mg S-1112 Scriptaid Description : Inhibitor of histone deacetylase (HDAC) with lower toxicity compared to trichostatin. 1mg S-1144 SDS, Research Grade Description : Detergent used to dissolve cell membranes and solubilize proteins. Used primarily for SDS-PAGE ( PolyAcrylamide) Gel Electrophoresis. Dust Free-SDS! New micropellet technology provides no dust, no sneezing, less irritation, less smell, and the same high purity you require. 500 g S-2066 Secretase Inhibitor Description : Reversible inhibitor of β-Secretase activity. 1 mg S-1118 Secretase Inhibitor Description : Reversible peptidomimetic inhibitor of Alzheimer's γ-Secretase activity. 1 mg S-1120 SF2415(A3) Product name : SF2415(A3) S-2028 SH-5 Description : Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines. 500 μg S-2024 SH-6 Description : Inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines. 500 μg S-2026 Simvastatin Product name : Simvastatin 50 mg S-2004 SIN-1.Chloride Description : A donor of superoxide and nitric oxide, which spontaneously forms peroxynitrite. Useful in free radical research. 10 mg M-1028 Sirtinol Description : Specific cell-permeable inhibitor of the sirtuin family of NAD-dependent deacetylases with no effect on human HDAC1. 1 mg S-1142 SKF-38393.HCl Description : D1 Dopamine receptor agonist. 25 mg S-1030 SKF-86002 Description : Blocks p38 (SAPK2a) activation. 5 mg S-1100 SKF91488.2HCl Description : Histamine N-methyltransferase inhibitor. S-2070 Ski (G8) Description : Immunogen: Recombinant V-Ski. Specificity: Detects cellular Ski at approx. 95kDA and hyperphosphorylated forms ranging to 115kDA in human, mouse, rat, chicken and Xenopus. Clone: G8. Isotype: Mouse IgG1. Application: ICC, IP, WB. 100 μg S-1132 SNAP Description : A Nitric Oxide donor which promotes vasodilatation. Stable analog of endogenous S-Nitroso compounds. 25 mg N-1015 SnoN (1G1) Description : Immunogen: Recombinant Ski-related novel protein non-Alu containing (SnoN). Specificity: Detects human and chicken SnoN at 80 kDa. Clone: 1G1. Isotype: Mouse IgG1.G393. Application: Immunoprecipitation, Western Blot. 100 μg S-1130 SP600125 Description : Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40nM for JNK-1 and JNK-2 and 90nM for JNK-3). Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. 5 mg S-2022 SPERMINE NONOate, SPER/NO Description : A Nitric Oxide Donor, useful for reliable generation of Nitric Oxide (NO) in vitro or in vivo. Half Life (t1/2) for NO release at 37°C is 39 minutes1. Half Life (t1/2) for NO release at 22°-25°C is 230 minutes1 25 mg S-1010 Spicamycins (most fatty analogues as a complex) Description : Recently purified metabolite. Please inquire. S-2052 SPRR2 (Human) Description : Source: Rabbit. Immunogen: synthetic peptide corresponding to aa 30-47 of human SPRR2A and SPRR2B . Specificity: Recognizes human SPRR2. Application: ICC, IHC(ps), WB. 100 μl S-2006 SQ-22536 Description : Cell permeable adenylate cyclase inhibitor. 1 mg S-1076 SQI-Pr(Na) Description : Sodium ionophore with selectivity of 100:1 for sodium over potassium. Effective at concentratioins of 1-5 uM. 500 μg S-2063 ssDNA (F7-26) Description : Differentiates between apoptosis and necrosis and can be used to detect early stages of apoptosis in cell suspensions. Recognizes deoxycytidine of ssDNA of at least 25-30 bases in length. Application: FC, ICC, IHC (FS, DS). Immunogen: Calf thymus ssDNA. 200 μl M-1074 STAT3 (activated)(Tyr705) Description : Specifically recognizes -AAPpYLKT- motif of activated human and mouse STAT3 phosphorylated at tyrosine-705. No cross reaction with non-phosphorylated STAT3 nor with unrelated tyrosine-phosphorylated proteins. Clone: 9E12. Isotype: Mouse IgG1. Application: ELISA, WB; IP. Includes positive control. 100 μg S-1102 STAT6 Description : Immunogen: Synthetic peptide corresponding to aa 630-650 of human STAT6. Specificity: Recognizes human STAT6 (~97 kDa). Clone: 8C12. Isotype: Mouse IgG1. Application: WB. Includes positive control. 100 μg S-1104 Staurosporine, in Solution Description : A cell permeable general inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase g (IC50 = 8.5 nM). From Streptomyces staurosporeus. 200 μl S-1016-SOL Staurosporine, Streptomyces staurosporeus Description : A cell permeable general inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase g (IC50 = 8.5 nM) 250 μg S-1016 Steffimycin B Description : Recently purified metabolite. Please inquire. S-2068 Sterigmatocystin, Aspergillus Versicolor Description : Mycotoxin that inhibits DNA synthesis. 5 mg S-1094 Streptozotocin Description : Widely used diabetes inducer in rodents. It has been demonstrated that STZ's inhibition of Bata-cell O-GlcNAcase is the mechanism that accounts for its diabetogenic toxicity. 100 mg S-2044 SU 4984 Description : An inhibitor of FGF and PDGF, but not EGF receptor 1 mg S-1126 SU 5416 Description : SU 5416 is an inhibitor of VEGF receptor. 1 mg S-1124 SU 6346 Product name : SU 6346 1 mg S-1128 SU 6656 Description : SU 6656 is a potent Src inhibitor and has high selectivity vs PDGF and EGF. *Purity by HPLC. S-1122 Subunit A of Protein Phoshatase 2A Description : The A (also termed PR65) subunit of PP2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit generating functionally diverse heterotrimers of the phosphatase. The A subunit also serves to regulate the polycation response of the phosphatase. S-1134 Sulfamethazine EIA Description : The sulfamethazine EIA kit is a rapid and simple detection system for sulfamethazine in swine plasma or serum. The antibiotic Sulfamethazine is commonly incorporated into swine feed as promoter of growth and for control of certain diseases in animals. 1 Kit S-1136 Sulfoβine-10 Description : Zwitterionic Detergent which retains its zwitterionic character over a broad pH range. 25 g S-1020 Sulfoβine-12 Description : Zwitterionic Detergent which retains its zwitterionic character over a broad pH range. 10 g S-1022 Sulfoβine-14 Description : Zwitterionic Detergent which retains its zwitterionic character over a broad pH range. 25 g S-1024 Sulfoβine-16 Description : Zwitterionic Detergent which retains its zwitterionic character over a broad pH range. 10 g S-1026 Sulfoβine-8 Description : Zwitterionic Detergent which retains its zwitterionic character over a broad pH range. 5 g S-1018 Sulochrin Description : VEGF Inhibitors. Anti-angiogenic agents that exert inhibitory activity on capillary-like tube formation of human μmbilical vein endothelial cells. Please inquire 10 mg S-2060 SUMO-1/Sentrin-1 (1-101), Human, Recombinant, Description : Inactive precursor of SUMO-1/sentrin-1 produced in bacteria. Substrate for the characterization of SUMO-1/sentrin-1 specific proteases. 250 μg S-1082 SUMO-1/Sentrin-1 (1-97), Human, Recombinant Description : Active standard for protein conjugation studies. Sufficient for about 40 assays. Recombinant human SUMO-1/Sentrin-1 (aa1-97) produced in bactercia. 500 μg S-1084 SUMO-1/Sentrin-1, Human Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa-1-21 of human SUMO-1/Sentrin-1. Specificity: Recognizes human, mouse, and rat SUMO-1/sentrin-1. Does not cross react with ubiquitin-like proteins (ubiquitin & NEDD8). Application: WB, IP, IHC. 200 μl S-1086 Suramin. Hexasodium Salt Description : P2x and P2y Purinergic receptor antagonist. Also shown to be an anti-parasitic and anti-tumor agent. Inhibits angiogenesis. 250 mg S-1012 Swinholide A, Theonella swinhoei Description : Disrupts actin cytoskeleton in cultured cells. 10 μg S-1074 Synuclein, Human Description : Immunogen: Synthetic peptide corresponding to aa 116-131 of human α-synuclein. Specificity: Recognizes human α-synuclein; does not cross-react with mouse α-synuclein or recombinant β- or γ-synuclein. Clone: 15G7. Isotype: Rat IgG2a. Application: IHC (Frozen Sections, Paraffin Sections), WB. 1 ml S-1114 TAPS Description : Biological buffer with a useful pH range of 7.7-9.1. pKa=8.4 at 25°C. 10 kg T-1018 TAT Control Peptide for JNK Inhibitor 1 (D-stereoisomer) Description : The kinase assays with recombinant JNK1α1 enzyme in the presence or absence of the L-JNKI1 or TAT peptides were performed as described. The L-TAT peptide serves as a control. In the upper panel the degree of JNK inhibition is determined by autoradiography of 32P-labelled c-Jun (aa 1-89). Coomassie staining of the gel (lower panel) shows that equal amounts of the c-Jun substrate was applied in all lanes. 25 μl T-1124 TAT, Control Peptide for JNK Inhibitor 1 (L-stereoisomer) Description : The kinase assays with recombinant JNK1α1 enzyme in the presence or absence of the L-JNKI1 or TAT peptides were performed as described. The L-TAT peptide serves as a control. In the upper panel the degree of JNK inhibition is determined by autoradiography of 32P-labelled c-Jun (aa 1-89). Coomassie staining of the gel (lower panel) shows that equal amounts of the c-Jun substrate was applied in all lanes. 50 μl T-1122 Tautomycin Description : Potent protein phosphatase inhibitor. This compound is cell permeable, and is a mixture of two isomers. 50 μg T-1142 TCEP.HCl Description : Ordoless disulfide reducing agent. More stable, resitan to air oxidation and effective than DTT. pH range is 1.5 to 8.5 1 g T-1180 TDZD-8 Description : Highly selective, non-ATP competitive inhibitor of GSK-3b (IC50=2µM). Binds to the active site of GSK3b. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50>100µM). 5 mg T-1132 Teleocidins Description : Recently purified metabolite. Please inquire. T-1170 TES, High Purity Product name : TES, High Purity T-1050 Tetrandrine Description : A blocker of L-type calcium channels. It also blocks Ca2+ activated K+ channel. 250 mg T-1046 TH-778 Description : Selective high affinity inhibitor of MRP1. 5 mg T-1054 Thalidomide Description : Inhibits TNF-α biosynthesis. Angiogenesis inhibitor. 100 mg T-1020 Thapsigargin Description : Cell-permeable tumor promoter which promotes the discharge of Ca2+ from intracellular stores by specifically inhibiting endoplasmic reticulum Ca2+-ATPase. This is achieved without the hydrolysis of inositolphopholipids. 5 mg T-1014 Thiocitrulline Description : A potent inhibitor of Neuronal and Inducible Nitric Oxide Synthase. 10 mg T-1010 TNF-α Description : ACRP30headless (human) 10 μg T-1060 TNF-α Description : ACRP30headless (mouse) 10 μg T-1062 TNF-α, Soluble, Human, Recombinant, Cell Culture Grade, Kit Description : Kit contains 50 μg of rhsTNF-α plus 2x50ug of an enhancer. In the presence of the enhancer, rhsTNF-α recognizes human and mouse TNF-R1 and human TNF-R2. With enhancer TNF-α shows a higher affinity for TNF-R2 than TNF-R1. 1 Kit T-1036 TNF-α, Soluble, Mouse, Recombinant, Cell Culture Grade, Kit Description : Kit contains 50 μg of rmsTNF-α plus 2x50ug of an enhancer. In the presence of the enhancer, rmsTNF-α recognizes human, mouse and rat TNF-R1 and human TNF-R2. With enhancer TNF-α shows a higher affinity for TNF-R2 than TNF-R1. 1 Kit T-1038 TNF-R1:Fc, Human Recombinant Description : Extracellular domain of human TNF-R1 (aa 1-211) is fused to the Fc portion of human IgG1. The recombinant fusion protein is produced in HEK 293T cells. Application: rhTNF-R1:Fc fusion protein can be used to block TNF-α mediated lysis with an inhibitory activity in a concentration range of 10-50ng/ml. Crossreactivity: rhTNF-R1:Fc interacts with mouse and human TNF-α. rhsTNF-α binds to TNF-R1 and triggers various biological effects (including cell death). 50 μg T-1032 TNF-R2:Fc Description : Extracelluar domain of human TNF-R2 (aa1-257) is fused to the Fc portion of human IgG1. The recombinant fusion protein is produced in HEK 293T cells. rhTNF-R2:Fc can be used to detect membrane-bound TNF-α-mediated lysis, but requires concentrations >1000 ng/ml. Since TNF-R2:Fc preferentially interacts with the membrane-bound form of TNF-α. Crossreactivity: rhTNF-R2:Fc interacts with human TNF-α. 50 μg T-1034 TRAIL Description : Produced in E. coli. The extracellular domain of human TRAIL is fused at the N-terminus to a His-tag and a linker peptide. Affinity purified. Note: this protein does not require a cross-linker (enhancer) for its potent biological activity. 10 ug T-1064 TRAIL (Human) (2E5) Product name : TRAIL (Human) (2E5) 100 μg T-1070 TRAIL (Human) (HS501) Description : Application: WB (excellent) 100 μg T-1076 TRAIL (Human) (lll6F) Description : Application: ELISA, FC, IHC (FS) (excellent), IP, WB. 100 μg T-1074 TRAIL (Human) (VI10E) Description : Source: Rabbit. Immunogen: rhsTRAIL (aa 95-261). Application: ELISA (excellent), FC, IP. 100 μl T-1078 TRAIL Receptor-1 to -4 Set Description : The Set contains 50 μg each of rhTRAIL-Rl, rhTRAIL-R2, rhTRAIL-R3: and rhTRAIL-R4:Fc 1 Set T-1080 TRAIL Receptor-1 to-4 Flow Cytometry Set Description : The set contains 100 μg each of Mab to TRAIL-R1, -R2, -R3 and -R4. Each Mab shows excellent specificity towards its receptor with no cross-reactivity to other receptors and high sensitivity to endogenous TRAIL-R's. 1 Set T-1082 TRAIL, Soluble (Human) (Rec.) Description : Produced in E. coli. The extracellular domain of human TRAIL is fused at the N-terminus to a FLAG-tag and an 8 aa linker peptide. 10 μg T-1066 TRAIL, Soluble (Human) (Rec.) Set Description : The set contains 10 μg of rhsTRAIL plus 2x50ug of an enhancer. In the presence of the enhancer, TRAIL induces apoptosis in a conc. Rang of 1-100ng/ml. 1 Set T-1068 TRAIL-R1 (CT) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 427-445 (D427SGKFIYLEDGTGSAVSLE445)of c-terminal human TRAIL-R1. 100 μg T-1088 TRAIL-R1 (CT) (Purified) Description : Synthetic peptide corresponding to aa 427-445 of human TRAIL-R1 with an added N-terminal cysteine. Concentration: 2091.3. 50 μg T-1090 TRAIL-R1 (Human) (HS101) Description : Immunogen: Recombinant human TRAIL-R1: Fc. Specificity: Recognizes human TRAIL-R1. Clone: HS101. Isotype: Mouse lgG1. FITC 100 tests T-1086 TRAIL-R1: Fc (Human) (Rec.) Description : Inhibits soluble TRAIL-induced apoptosis in a conc. Range of 2-10 ug/ml. 50 μg T-1084 TRAIL-R2 (Purified) Description : Source: Goat. Immunogen: Synthetic peptide corresponding to aa 68-94 of the extracellular domain of N-termial human TRAIL-R2. Specificity: recognizes human and mouse TRAIL-R2. 100 μl T-1098 TRAIL-R2 ( Human) (HS201) Description : Immunogen: Recombinant human TRAIL-R2: FC. Specificity: Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, R3 or R4. Isotype: Mouse lgG1. 100mg T-1094 TRAIL-R2 (CT) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 388-407 of human TRAIL-R2 precursor. Recognizes human and mouse TRAIL-R2. Application: WB. Blocking. 100 μg T-1096 TRAIL-R2: Fc (Human) (Rec.) Description : Inhibits soluble TRAIL-induced apoptosis. Range of 0.1-0.5ug/ml. 50 μg T-1092 TRAIL-R3 (Human) (HS301) Description : Immunogen: Recombinant human. TRAIL-R3: Fc. Specificity: Recognizes human TRAIL-R3. Does not cross-react with human TRAIL-R1, R2 and R4. Isotype: Mouse lgG1. 100 μg T-1106 TRAIL-R3 (Human) (LEIA) Description : Immunogen: Recombinant human TRAIL-R3: Fc. Specificity: Recognizes human TRAIL-R3. Isotype: Rat lg G2a. 100 μg T-1108 TRAIL-R3 (Human) (Purified) Description : Source: Goat. Immunogen: Synthetic peptide corresponding to aa 33-63 of the extracelluar domain of human TRAIL-R3. Specificity: Recognizes human TRAIL-R3. 200 ug T-1110 TRAIL-R3: Fc (Human) (Rec.) Description : Inhibits soluble TRAIL-induced apoptosis in a conc. Rang of 50-100 μg/ml. 50 μg T-1104 TRAIL-R4 (Human) (HS402) Description : Immunogen: Recombinant human TRAIL-R4: Fc. Specificity: Recognizes human TRAIL-R4. Does not cross-react with human TRAIL-R1, R2 and R3. Isotype: Mouse lgG1. 100 μg T-1116 TRAIL-R4 (ID) (Purified) Description : Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 249-263 of the internal domain of human TRAIL-R4 perecrsor. Specificity: Detects human, mouse and rat TRAIL-R4. Application: WB. Blocking. T-1118 TRAIL-R4: Fc (Human) (Rec.) Description : Inhibits soluble TRAIL induced apoptosis in a conc. Range of 2-10 ug/ml. 50 μg T-1114 Tranilast Description : Inhibitor of VEGF-induced angiogenesis. Also anti-allergic agent. 10 mg T-1048 Trichodion, Trichospdriella sp. Description : Inhibits NF-Bκ (IC50=42-84uM), AP-1 (IC50=21uM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS11 (iNOS) expression. 100 μg T-1152 Trichostatin A Description : From Streptomycs Platensis. Inhibits Histone deacetylase. Blocks cell cycle progression at the GI phase in Hela cells. Also demonstrates immunosuppressive activity. 1 mg T-1052 Trichostatin B Description : Recently purified metabolite. Please inquire. T-1172 Trichostatin C Description : Recently purified metabolite. Please inquire. T-1174 Trideoxy-Ins(1,4,5)P3. 6Na Description : Exhibits relatively low ligand binding affinity to the Ins(1,4,5)P3 receptor of bovine adrenal cortex membranes and acts as a weak agonist in releasing calcium from saponin permeablized SH-Sy5Y human neurolastoma cells. T-1028 TRIM Description : An inhibitor of Nevronal Nitric Oxide Synthase (nNOS). 50 mg T-1022 Triptolide, Tripterygium wilfordii Description : Immunosuppressant with anti-inflammatory and anti-tumor properties. More effective in preventing T cell proliferation and interferon-γ than FK506. Inducer of apoptosis. 1 mg T-1030 Tris.Base, Mole-Ready, Molecular Biology Grade Description : 16 pouches / Box. 60.5 g (0.5 mole) / pouch. High purity biological buffer. Pre-weighed based on molar weight instead of grams in ready-to-use pouches. Stock solutions are easy and fast to prepare. DNase, RNase and Proteases not detected.Ready-to-use. Prepare stock solution without weighing the dry product. Moisture proof pouches ensure high quality and ease of use. 1 Box T-1178 Tris.HCl, Mole-Ready Form, Molecular Biology Grade Description : High purity biological buffer. Pre-weighed based on molar weight instead of grams in ready-to-use pouches. Stock solutions easy and fast to prepare. DNase, RNase and Proteases not detected. Ready-to-use. Prepare stock solution without weighing the dry product. Moisture proof pouches ensure high quality and ease of use. Purity data is for a dried basis. 1 Box T-1176 Triton X Non-Ionic Detergent EIA Description : The IDR Triton X EIA kit is a modified and improved system for the determination of Triton X in the sample. It is often difficult to remove detergents from the macromolecules, and analysis of bound detergent in biochemical sample becomes important. Quantification of these nonvolatile detergents is therefore a frequently encountered problem both for their residue analysis as well as for their presence in biochemical products. I Kit T-1056 Tryprostatin A Description : Inhibitor of microtubule assembly. Also inhibits cell cycle progression at the M phase. Host: Isolated from aspergillus fumigatus. 500 μg T-1134 Tunicamycin, Streptomyces Iysosuperficus Description : Antibiotic useful in glycoprotein research. Inhibitor of N-linked glycosylation and the formation of N-glycosidic protein-carbohydrate linkages. 10 mg T-1016 Tylosine EIA Description : The Tylosin EIZ kit is a rapid and simple detection system for tylosin in feed extract, and other sample extract. is a macrolide antibiotic that is active against gm-positive and gm-negative bacteria. It is also effective in treating respiratory diseases caused by mycoplasms. 1 Kit T-1058 Tyramine (rabbit) Description : Polyclonal antisera were raised in rabbits after immunization with the conjugates: Tyramine-Glutaraldehyde-Carriers. Specificity: Using a conjugate Tyramine-Glutaraldhyde-Protein, antibody specificity was performed with an ELISA test by competition experiments with the following compound (1). Tyramine-G-BSA: 1, Octopamine-G-BSA: 1/830, Tyrosine-G-BSA: 1/>100,000 , Dopamine-G-BSA: 1/>40,000 100 μl T-1126 U0126 Description : Potent and specific inhibitor of MEK1 and MEK2. Blocks the production of inflammatory cytokines and matrix metalloproteinases. Does not inhibit PKA, PKC or CaM KII. 1 mg U-1026 Ubc10 (His)6, Human, Recombinant Description : UbcH10 catalyzes the destruction of both cyclin A and cyclin B in conjunction with the anaphase-promoting complex; and therefore, plays an important role in the control of the cell exit from mitosis. Formulation: 0.7 mg/ml in 50 mM HEPES, 125 mM NaCl, 10% Glycerol, 1 mM DTT, pH 8.0. 50 μg U-1078 Ubc5b, Human, Recombinant Description : UBCH5s are human homologs of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer. UBC5 is an essential gene in yeast. UbCH5 mediates the degradation a myriad of short-lived regulatory proteins. 50 μg U-1068 Ubc5c, (GST), Human, Recombinant Description : UBCH5s are human homologs of the yeast UBC4/5 family and play many important regulatory roles in inflammation and cancer. UBC5 is an essential gene in yeast. UbCH5 mediates the degradation a myriad of short-lived regulatory proteins. 50 μg U-1070 Ubc7, Human, Recombinant Description : Evidence suggests that this E2 is involved in the degradation of non-''N-end rule'' protein substrates, certain N-a-acetylated proteins, and tumor suppressor protein p53. Ubc7 in yeast is inducible by cadmium and confers resistance to this stress signal. 50 μg U-1074 Ubc9, Human, Purified Description : Source: Sheep purified. Liquid. Immunogen: Synthetic peptide corresponding to aa 147-158 of C-terminal human Ubc9. Specificity: Recognizes human Ubc9. Application: WB ICC. 50 μg S-1092 Ubc9, Human, Recombinant Description : Mediates the conjugation of the ubiquitin-like protein SUMO-1 to a variety of proteins including RanGAP1, IκBα, and PML without the requirement of an ubiquitin ligase (E3). 50 μg U-1076 Ubc9, Human, Recombinant, Produced in E. coli. Description : Catalyzes formation of an isopeptide bond between the C-terminus of SUMO-1/sentrin-1 and e-amino groups in the target protein. Sufficient for 80 assays of SUMO-1/sentrin-1 conjugation to a protein substrate. Formulation: 50µg in 50mM Tris HCl, pH 8.0, 500mM NaCl, 1mM DTT, 10% Glycerol. 50 μg S-1088 UbcH2 / E2-14K (GST) Description : E2-14K is the human homolog to the yeast DNA repair gene RAD6 and is induced by DNA damaging agents. E2-14K is associated with cancer-induced cachexia and the degradation of ''N-end rule'' substrates. 50 μg U-1062 UbcH3 / Cdc34 (His)6 Description : Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. 50 μg U-1064 Ubiquitin Activating Enzyme (E1), Human Description : Enzyme responsible for the first step in ubiquitin-protein isopeptide bond formation. E1 catalyzes the activation of the C-terminal carboxyl group of ubiquitin by forming a high-energy thioester bond in an ATP-dependent manner. Prodcut 25ug (untagged) U-1090 Ubiquitin Activating Enzyme (E1), Rabbit Description : Enzyme responsible for the first step in ubiquitin-protein isopeptide bond formation. E1 catalyzes the activation of the C-terminal carboxyl group of ubiquitin by forming a high-energy thioester bond in an ATP-dependent manner. Product p roduced by Proteome. 25 μg U-1056 Ubiquitin Activating Enzyme (E1), Yeast Description : Enzyme responsible for the first step in ubiquitin-protein isopeptide bond formation. E1 catalyzes the activation of the C-terminal carboxyl group of ubiquitin by forming a high-energy thioester bond in an ATP-dependent manner. 50 μg U-1054 Ubiquitin Aldehyde, Synthetic Description : Potent and highly specific inhibitor of all ubiquitin hydrolases. Blocks the hydrolysis of polyUbiquitin chains on substrate proteins by this family of enzymes in vitro. Ub-H enhances polyUb chain accumulation on radiolabeled substrates. 50 μg U-1040 Ubiquitin C-terminal Hydrolase, Isopeptidase-T (Ipase-T) Description : Ipase-T is a member of the high molecular weight group of UCHs involved in the hydrolysis of isopeptide linkages of polyUb chains. It is believed to play a critical role in the recycling of Ub and in the regulation of the activity of the 26S proteasome. 10 ug U-1058 Ubiquitin C-terminal Hydrolase, UCH-L3 (UCH 30kDa) Description : UCH-L3 is a member of the low molecular weight UCHs involved in the hydrolysis of small C-terminal derivatives of Ub. Activity can be measured using Ub-ethylester or Ub-AMC. 25 μg U-1060 Ubiquitin Conjugating Enzyme Fractions, Mammalian Description : The enzyme fractions supplied represent the full compliment of purified conjugation enzymes (E1, E2s, and E3s) that are found in mammalian Fraction II. The enzymes have been tested and shown to work with labeled substrate proteins. 400 μg U-1042 Ubiquitin K48R, Human, Recombinant Description : Ideal for the reduction in polyUb chain length / conjugation rates and determining if polyUb chains are K48 or alternate lysine linked. Mutation of lysine 48 to arginine renders ubiquitin unable to form polyUb chains via lysine 48 linkages with other Ub molecules. 1 mg U-1034 Ubiquitin, Bovine Description : Methylated Ub can form an E1-catalyzed active thioester at the C-terminus allowing the molecule to be transferred to the lysines of substrate proteins (mono-ubiquitination). Ideal for the reduction in polyUb chain length as well as conjugation rates. Reductive methylation of amines render ubiquitin unable to form polyUb chains via lysine linkages with other Ub molecules. 1 mg U-1036 Ubiquitin, Human, Recombinant Description : Fully functional ubiquitin N-terminally tagged Glutathione S-transferase (GST). GST-Ub allows for glutathione affinity purification of ubiquitinated molecules and for immunodetection of conjugates using GST antibodies. 1 mg U-1030 Ubiquitin, Mammalian, Recombinant Description : Fully functional His-tagged (N-terminus) ubiquitin. (His)6-Ub allows for metal chelate affinity purification of ubiquitinated molecules and for immunodetection of conjugates using (His)6 specific antibodies. 2 mg U-1032 Ubiquitin-AMC, Bovine Description : Fluorogenic substrate for ubiquitin hydrolases. Ubiquitin-AMC was shown to be an exquisitely sensitive substrate for UCH-L3 (Km = 0.039 μM) and for the UBP Isopeptidase-T (Km = 0.17 - 1.4 µM). 50 μg U-1028 Ubiquitin-SepharoseTM, Bovine Description : Covalently linked Ub to SepharoseTM beads via primary amine coupling leaving the C-terminus free. Useful for affinity binding of Ub activating enzyme (E1), Ub carrier enzymes (E2s), Ub ligases (E3s) and Ub C-terminal hydrolases (UCHs). 1 ml U-1038 UK-14304 Description : α-Adrenoceptor agonist. 100 mg U-1024 Urea, Mole-Ready, Ultrapure Grade Description : 24 pouches per box, 42.1 g (0.7 mole) / pouch. Urea is a protein & nucleic denaturant. Mole-Ready form. Pre-weighed based on molar weight instead of gms in ready-to-use pouches. Stock solutions can be prepared without weighing. Purity data reflects DNase, RNase- Proteases not detected. 1 Box U-1082 V-Pyrro/NO Description : Liver-selective nitric oxide donor that blocks TNF-α-induced apoptosis and toxicity. 5 mg V-1043 Valeryl Salicylate Description : Selective Inhibitor of Cyclooxygenase-1 (COX-1). 100 mg V-1037 Valinomycin, Streptomyces fulvissimus Description : Antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer. Valinomycin is used diagnostically in ion selective electrodes because of its preferential ability to conduct K+ across the electrode’s membrane. 50 mg V-1013 Vancomycin.HCL, Streptomyces orientalis, Cel culture Tested Description : Glycopeptide antibiotic that inhibits gm-positive microorganisms. Interferes with cell wall synthesis. Often used with cefotaxime or carbenicillin to produce a wide spectrum of activity against gm-positive and g negative bacteria. Mosty common concentrations utilized are in the range of 50-100 μg/ml. Potency: >1000 μg per mg. 1 g V-1065 Vascular Adhesion Molecule-1 (VAP-1)(Human)(TK8-14-10) Description : Immunogen: Human VAP-1. 100µg Lyophilized from PBS (pH 7.2-7.4). Contains no preservatives. Specificity: Recognizes monomeric (90kDa) and dimeric (170-180kDa) human VAP-1. Clone: TK8-14-10. Isotype: Mouse IgG2a. Application: ELISA, FC, IHM, WB, FUNC (inhibits human VAP-1) 100 μg V-1057 VASP (IE 273) Description : Immunogen: Purified human vasodilator stimulated posphoprotein (VASP). Specificity: To human VASP. Isotype: Mouse IgG1. Application: WB, IF. Clone: 1E273. 50 μg V-1049 VASP (M4) Description : Source: Rabbit. Immunogen: Purified VASP from human platelets. Specificity: To human VASP. Crossreacts with mouse, rat, canine, porcine, and chicken VASP. Application: IF (acetone or formaldehyde fixed cells), IP, WB. Recognizes both the 46 kDa (Ser157-dephospho) and 50 kDa (Ser157-phospho) forms. Especially with rodent cells and tissues there may be a reactivity with an 80 kDa band of yet unknown identity. 100 μl V-1051 VASP, Activated, Ser239 Description : Specificity: Recognizes only Ser239-phosphorylated VASP (a site preferred by cGMP-dependent protein kinase (PKG), but also used by cAMP-dependent protein kinase A (PKA). Can be used to monitor PKG/PKA activity. Application: WB, ICC, FC. Clone: 16C2. Isotype: Mouse IgG1. Purified 100 μg V-1047 VDM11 Description : Selective inhibitor of anandamide uptake that does not activate vanilloid receptor VR1. 1 mg V-1061 VDM13 Description : Selective inhibitor of anandamide uptake that does not activate vanilloid receptor VR1. 5 mg V-1059 Venturicidin B Description : Recently purified metabolite. Please inquire. V-1070 Verruculogen, Penicillium verruculosum Description : Tremorgenic mycotoxin. Potent inhibitors of Ca activated K(maxi K) channel. 5 mg V-1000 Verucopeptin Description : Antitumor Antibiotic. 50 mg V-1063 Vinblastine Sulfate Description : Inhibits microtubule assembly. Induces apoptosis and acts as a cancer chemotherapeutic agent. 10 mg V-1053 Vincristine Sulfate Description : Inhibits microtubule assembly. Induces apoptosis and acts as a cancer chemotherapeutic agent. 5 mg V-1055 Vinpocetine Description : Inhibitor of Ca2+/Calmodulin-dependent phosphodiesterase. Shown to be cerebral vasodilator. 5 mg V-1035 Wortmannin, Penicillium wortmanni Description : A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase (MAPK) and myosin light-chain kinase (MLCK). 1 mg W-1022 WP631.2HCl Description : Synthetic fluorescent bisintercalating anthracycline antibiotic with ultratight binding properties to DNA. Appears to overcome MRP-mediated multidrug resistance. 100 μg W-1028 WY-14,643 Description : Widely used activator of peroxisome proliferator activator receptors (PPARs). PPARs belong to the family of nuclear hormone receptor transcription factors 10 mg W-1026 X-206 [Desmethylalborixin] Description : Ionophoric. Chelates monovalent cations, preferably sodium ions and transports them passively through biological membranes. Displays antimicrobial and cytotoxic properties and selective and potent antimalarial activity. 1 mg X-1007 X-Galactosaminide Product name : X-Galactosaminide 500 mg X-1011 Xanthohumol, Humulus lu pulus Description : Prenylated chalcone isolated from hop (Humulus lupulus) and found in beer. Potent inhibitor of diacylglycerol acetyltransferase [DGAT], inhibits DNA polymerase and induces cell differentiation. 5 mg X-1003 XE-CCG-I Description : Selective and highly active group II mGluR antagonist with a subtype specificity towards the mGlu3 receptor. No activity towards group I and group III mGluRs. 1 mg X-1001 Xestospongin C Description : A reversible and membrane-permeable blocker of IP3-mediated Ca2+ release. It does not interact with the IP3-binding site. 100 μg X-1009 YC-1 Description : A direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide. 5 mg Y-1000 Yohimbine.HCl Description : α2-adrenoceptor blocker. Y-1002 Z-Leu-Leu-Leu-B(OH)2 Description : Highly potent and selective cell permeable inhibitor of the proteasome. Structurally similar to MG-132 but with much higher potency. Ki=0.023 nM vs. SDS-activated 20S Proteasome. 200 μg Z-1003 Zaprinast Description : Specific cGMP-phosphodiesterase inhibitor. 10 mg Z-1001 Zearalenone from Fusarium graminearum Description : Mycotoxin commonly found in grains. 50 mg Z-1005 Zeatin Product name : Zeatin 10 mg Z-1004 Zeatin Description : Naturally occurring cytokinin growth regulator. Promotes cell division and also influences other steps of the cell cycle. 10 mg Z-1007 Zeatin Riboside Description : Main effects in tissue culture systems include control of shoot growth and formation, cell division and inhibition of leaf senescence. 25 mg Z-1006 Description : Immunogen:Synthetic peptide corresponding to aa 28-38 (M28GDYMAQEDDW38) of human and rat actinin-4 and to aa 29-39 of mouse actinin-4. Specificity: Recognizes human, mouse, pig, Chinese hamster and marsupial actinin-4. Does not cross-react with actinin-1, -2 or -3. 50 µg A-1262

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