| Marque/Mark : | BIOCHIMIE (A.G.) | | Sub Category : | BIOCHIMIE (A.G.) | | Product : | AAG | | Catalogue : | A-1256 |
Product description
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as ''client proteins.'' These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others. 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.
| Product line : | Signal Transduction, Neurobiology, Apoptosis, Cancer Research | | | | Sub product line : | Stress Response, Cell Cycle, Inhibitor, Antibiotic, Immune Response, Angiogenesis, Fermentation | | | | Formula Chimical : | C31H43N3O8 | | | | Chimical Name : | 17-(Allylamino)-17-demethoxygeldanamycin, (17-AAG) | | | | Solubility : | DMSO, Methanol: Clear purple solution at 10mg/ml. | | | | Molecular Weight : | M.W. 585.7 | | | | CAS NUMBER : | CAS [75747-14-7] | | | | Purity : | Purity: ≥98% | | | | Melting Point : | MP: 203-205°C | | | | Appear : | Purple Powder | | | | Handling : | Store in tightly Sealed Vial. Protect from light. | | | | Storage : | +4°C | | | | Comments : | 17-AAG is a less toxic analog of the geldanamycin. |
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